CRCGN010_HEPG2_24H:N08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN010_HEPG2_24H:N08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
LCN2 lipocalin 2 4.08641
CHN1 chimerin 1 3.70576
C2CD2 C2 calcium-dependent domain containing 2 3.67873
CIAO3 cytosolic iron-sulfur assembly component 3 3.35987
CHMP6 charged multivesicular body protein 6 3.34941
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.22857
RPL39L ribosomal protein L39-like 3.21179
STK10 serine/threonine kinase 10 3.20839
LOC122526780 uncharacterized LOC122526780 3.18013
PHKG2 phosphorylase kinase, gamma 2 (testis) 3.13948
AMDHD2 amidohydrolase domain containing 2 3.02787
PLS1 plastin 1 2.98402
NOSIP nitric oxide synthase interacting protein 2.93207
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.80261
ADGRE5 adhesion G protein-coupled receptor E5 2.78171
GSTZ1 glutathione S-transferase zeta 1 2.66357
TATDN2 TatD DNase domain containing 2 2.47757
CCL2 chemokine (C-C motif) ligand 2 2.42538
CYCS cytochrome c, somatic 2.42123
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.41113
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.3904
FPGS folylpolyglutamate synthase 2.37536
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.37382
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.35105
ARID4B AT rich interactive domain 4B (RBP1-like) 2.3197
EHBP1L1 EH domain binding protein 1-like 1 2.28492
PGLYRP1 peptidoglycan recognition protein 1 2.27808
RAB11FIP2 RAB11 family interacting protein 2 (class I) 2.25893
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.23206
CCT2 chaperonin containing TCP1, subunit 2 (beta) 2.21906
PFKL phosphofructokinase, liver 2.17293
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.10944
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.09251
PRR15L proline rich 15-like 2.09074
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.07293
GUK1 guanylate kinase 1 2.05422
IRGQ immunity-related GTPase family, Q 2.02669
UBE2G2 ubiquitin-conjugating enzyme E2G 2 2.02136

decreased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 -7.65288
OXA1L oxidase (cytochrome c) assembly 1-like -6.42581
VAT1 vesicle amine transport 1 -5.73007
FGFR4 fibroblast growth factor receptor 4 -4.94824
DNM1L dynamin 1-like -3.83073
PCCB propionyl CoA carboxylase, beta polypeptide -3.62967
PLK1 polo-like kinase 1 -3.45526
NRIP1 nuclear receptor interacting protein 1 -3.41695
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.07446
GNAS GNAS complex locus -3.0431
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.00673
TLCD3A TLC domain containing 3A -3.00244
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.94098
THAP11 THAP domain containing 11 -2.92241
MRPS2 mitochondrial ribosomal protein S2 -2.90293
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.69697
WASHC4 WASH complex subunit 4 -2.57376
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.56446
GOLT1B golgi transport 1B -2.55255
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.3962
CDC20 cell division cycle 20 -2.32234
COG2 component of oligomeric golgi complex 2 -2.30588
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.27973
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.24453
TMEM214 transmembrane protein 214 -2.19238
FOCAD focadhesin -2.07695
TXNDC9 thioredoxin domain containing 9 -2.06483
TPCN1 two pore segment channel 1 -2.0099