CRCGN010_HEPG2_24H:N12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinyl toluene 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

57 genes differentially expressed following the CRCGN010_HEPG2_24H:N12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AMDHD2 amidohydrolase domain containing 2 5.80673
STK10 serine/threonine kinase 10 5.73825
MAP7 microtubule-associated protein 7 4.4113
LPAR2 lysophosphatidic acid receptor 2 3.99492
E2F2 E2F transcription factor 2 3.72849
CXCL2 chemokine (C-X-C motif) ligand 2 3.61366
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.57679
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.46805
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.40954
NOTCH1 notch 1 3.36959
SATB1 SATB homeobox 1 3.12553
DIPK1A divergent protein kinase domain 1A 2.97566
SMIM40 small integral membrane protein 40 2.93752
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.83387
PEX11A peroxisomal biogenesis factor 11 alpha 2.79317
BZW2 basic leucine zipper and W2 domains 2 2.61436
EVL Enah/Vasp-like 2.5873
PLSCR3 phospholipid scramblase 3 2.57171
TREM1 triggering receptor expressed on myeloid cells 1 2.54816
GSTZ1 glutathione S-transferase zeta 1 2.46359
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.37312
NMU neuromedin U 2.29417
LOC122526780 uncharacterized LOC122526780 2.27901
UBQLN2 ubiquilin 2 2.26491
BIRC2 baculoviral IAP repeat containing 2 2.22767
SSBP2 single-stranded DNA binding protein 2 2.21804
HLA-DRA major histocompatibility complex, class II, DR alpha 2.20999
CISD1 CDGSH iron sulfur domain 1 2.20282
ADAM10 ADAM metallopeptidase domain 10 2.1725
NOSIP nitric oxide synthase interacting protein 2.10271
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.09647
CHN1 chimerin 1 2.06697
HBA1 hemoglobin, alpha 1 2.0568
RFC5 replication factor C (activator 1) 5, 36.5kDa 2.03513
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.01928
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.00865

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.63588
ADI1 acireductone dioxygenase 1 -5.46239
DNM1L dynamin 1-like -4.25615
NRIP1 nuclear receptor interacting protein 1 -4.17657
ANKRD10 ankyrin repeat domain 10 -4.0416
KDM3A lysine (K)-specific demethylase 3A -3.88219
ZNF586 zinc finger protein 586 -3.71434
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.69481
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.50388
LDHD lactate dehydrogenase D -3.35499
VDAC1 voltage-dependent anion channel 1 -2.96087
HSPB1 heat shock 27kDa protein 1 -2.89259
FGFR4 fibroblast growth factor receptor 4 -2.76396
RBM15B RNA binding motif protein 15B -2.43889
HYOU1 hypoxia up-regulated 1 -2.30694
COG2 component of oligomeric golgi complex 2 -2.24982
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.1995
GNAS GNAS complex locus -2.18792
BLCAP bladder cancer associated protein -2.18328
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -2.07291
P3H2 prolyl 3-hydroxylase 2 -2.00679