CRCGN010_HEPG2_24H:N13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cupferron 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN010_HEPG2_24H:N13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 4.64325
JADE2 jade family PHD finger 2 3.72647
STIMATE STIM activating enhancer 3.64231
PPARG peroxisome proliferator-activated receptor gamma 3.16949
HLA-DMA major histocompatibility complex, class II, DM alpha 3.12775
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.12327
PRKCH protein kinase C, eta 3.09519
MAP7 microtubule-associated protein 7 2.87084
HMOX1 heme oxygenase 1 2.86363
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.8468
CIAO3 cytosolic iron-sulfur assembly component 3 2.78629
E2F2 E2F transcription factor 2 2.70708
MAMLD1 mastermind-like domain containing 1 2.63212
CARMIL1 capping protein regulator and myosin 1 linker 1 2.60577
FOXJ3 forkhead box J3 2.59527
UBQLN2 ubiquilin 2 2.57201
BPHL biphenyl hydrolase-like (serine hydrolase) 2.53691
TXNRD1 thioredoxin reductase 1 2.39251
BIRC2 baculoviral IAP repeat containing 2 2.29852
TEX10 testis expressed 10 2.28815
LCN2 lipocalin 2 2.16254
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.09225
CHN1 chimerin 1 2.06669
RXYLT1 ribitol xylosyltransferase 1 2.03782
NMU neuromedin U 2.01474

decreased expression

Symbol Name Standardized Value
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.78144
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.7566
LDHD lactate dehydrogenase D -3.56071
PEG10 paternally expressed 10 -3.51381
DDIT4 DNA-damage-inducible transcript 4 -3.47374
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.2646
CCDC86 coiled-coil domain containing 86 -3.14634
NUP85 nucleoporin 85kDa -3.11149
TLR4 toll-like receptor 4 -3.10395
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.90246
PPOX protoporphyrinogen oxidase -2.87962
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.68165
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.67816
ZDHHC6 zinc finger, DHHC-type containing 6 -2.67566
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.45294
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.39501
USP6NL USP6 N-terminal like -2.27374
OXA1L oxidase (cytochrome c) assembly 1-like -2.25958
MYL9 myosin, light chain 9, regulatory -2.24585
YME1L1 YME1-like 1 ATPase -2.14741
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.12249
MRPS7 mitochondrial ribosomal protein S7 -2.08118
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.06255
KCTD2 potassium channel tetramerization domain containing 2 -2.00681