CRCGN010_HEPG2_24H:N15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cupferron 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

78 genes differentially expressed following the CRCGN010_HEPG2_24H:N15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STK10 serine/threonine kinase 10 5.51075
PPARG peroxisome proliferator-activated receptor gamma 5.31262
MSRA methionine sulfoxide reductase A 4.99592
GPATCH8 G patch domain containing 8 4.77448
NMU neuromedin U 4.7047
EGF epidermal growth factor 4.59255
AMDHD2 amidohydrolase domain containing 2 4.52369
CARMIL1 capping protein regulator and myosin 1 linker 1 4.45024
CYCS cytochrome c, somatic 4.3453
CSK c-src tyrosine kinase 4.34121
MINDY1 MINDY lysine 48 deubiquitinase 1 4.30153
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.20025
GSTZ1 glutathione S-transferase zeta 1 4.12616
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.89305
MOK MOK protein kinase 3.8517
HOXA10 homeobox A10 3.84521
MAP7 microtubule-associated protein 7 3.82382
KCNK1 potassium channel, two pore domain subfamily K, member 1 3.79063
HLA-DMA major histocompatibility complex, class II, DM alpha 3.52882
POLG2 polymerase (DNA directed), gamma 2, accessory subunit 3.43909
LCN2 lipocalin 2 3.4131
VGLL4 vestigial-like family member 4 3.14635
ZNF589 zinc finger protein 589 2.87218
CHN1 chimerin 1 2.85167
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.76989
UFM1 ubiquitin-fold modifier 1 2.68067
RXYLT1 ribitol xylosyltransferase 1 2.56619
HOOK2 hook microtubule-tethering protein 2 2.49695
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.38924
ARID4B AT rich interactive domain 4B (RBP1-like) 2.37612
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.37188
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 2.33295
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.30213
FZD1 frizzled class receptor 1 2.27413
RGS16 regulator of G-protein signaling 16 2.23019
STXBP2 syntaxin binding protein 2 2.18821
SMIM40 small integral membrane protein 40 2.1605
NUP210 nucleoporin 210kDa 2.1328
JADE2 jade family PHD finger 2 2.11638
UCN urocortin 2.10852
ONECUT2 one cut homeobox 2 2.09723
ORC6 origin recognition complex, subunit 6 2.09519
PARP2 poly (ADP-ribose) polymerase 2 2.08778
RUVBL1 RuvB-like AAA ATPase 1 2.07461
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1 2.04517
HOXA10-HOXA9 HOXA10-HOXA9 readthrough 2.0192

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -9.00428
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -8.98075
LDHD lactate dehydrogenase D -8.92665
ADI1 acireductone dioxygenase 1 -5.3501
FBXL12 F-box and leucine-rich repeat protein 12 -4.95473
VAT1 vesicle amine transport 1 -4.84575
TLCD3A TLC domain containing 3A -3.98089
NUP85 nucleoporin 85kDa -3.88689
NCK1 NCK adaptor protein 1 -3.39419
OXA1L oxidase (cytochrome c) assembly 1-like -3.38683
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.2611
USP6NL USP6 N-terminal like -3.25359
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -3.03494
ZNF586 zinc finger protein 586 -3.00273
TLR4 toll-like receptor 4 -2.92938
STAMBP STAM binding protein -2.70774
MTFR1 mitochondrial fission regulator 1 -2.61034
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.50947
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.50049
ZMIZ1 zinc finger, MIZ-type containing 1 -2.44057
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.3898
EIF5 eukaryotic translation initiation factor 5 -2.28958
MRPS7 mitochondrial ribosomal protein S7 -2.28283
KMT5A lysine methyltransferase 5A -2.17173
NRIP1 nuclear receptor interacting protein 1 -2.165
C5 complement component 5 -2.16495
GET1 guided entry of tail-anchored proteins factor 1 -2.11959
RBM15B RNA binding motif protein 15B -2.1116
EXT1 exostosin glycosyltransferase 1 -2.04099
FBXL6 F-box and leucine-rich repeat protein 6 -2.03558
PLA2G15 phospholipase A2, group XV -2.01162
CHPT1 choline phosphotransferase 1 -2.00256