CRCGN010_HEPG2_24H:N19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 21.42 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

159 genes differentially expressed following the CRCGN010_HEPG2_24H:N19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
INPP1 inositol polyphosphate-1-phosphatase 6.51955
CNPY3 canopy FGF signaling regulator 3 6.03502
CCL2 chemokine (C-C motif) ligand 2 5.71461
TIMP2 TIMP metallopeptidase inhibitor 2 5.64345
SQOR sulfide quinone oxidoreductase 5.04808
ADGRE5 adhesion G protein-coupled receptor E5 4.78014
TXNRD1 thioredoxin reductase 1 4.77856
CTSL cathepsin L 4.39442
NUCB2 nucleobindin 2 4.36809
TOMM34 translocase of outer mitochondrial membrane 34 4.3268
C2CD2 C2 calcium-dependent domain containing 2 4.24414
MVP major vault protein 3.80981
SQSTM1 sequestosome 1 3.7833
JADE2 jade family PHD finger 2 3.77766
UGDH UDP-glucose 6-dehydrogenase 3.68725
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.60624
CCDC92 coiled-coil domain containing 92 3.53441
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.51737
STX1A syntaxin 1A (brain) 3.50188
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.47222
FOSL1 FOS-like antigen 1 3.46926
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.41825
CDC45 cell division cycle 45 3.29886
CHN1 chimerin 1 3.17034
RALB v-ral simian leukemia viral oncogene homolog B 3.1494
IL4R interleukin 4 receptor 3.13416
GLRX glutaredoxin (thioltransferase) 3.10006
KIFBP kinesin family binding protein 3.09557
DUSP3 dual specificity phosphatase 3 3.00998
TRIB1 tribbles pseudokinase 1 2.92436
ABHD6 abhydrolase domain containing 6 2.92064
EGR1 early growth response 1 2.87406
NANOS3 nanos homolog 3 (Drosophila) 2.86803
ITGB5 integrin, beta 5 2.73728
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.72106
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.62969
CDPF1 cysteine-rich, DPF motif domain containing 1 2.61513
BPHL biphenyl hydrolase-like (serine hydrolase) 2.59537
DUSP6 dual specificity phosphatase 6 2.59396
IER3 immediate early response 3 2.57017
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.54354
BIRC2 baculoviral IAP repeat containing 2 2.53657
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 2.48356
SPON2 spondin 2, extracellular matrix protein 2.45563
CFLAR CASP8 and FADD-like apoptosis regulator 2.43931
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.43599
GRB10 growth factor receptor-bound protein 10 2.43244
PHC2 polyhomeotic homolog 2 (Drosophila) 2.41972
RXYLT1 ribitol xylosyltransferase 1 2.39124
VGLL4 vestigial-like family member 4 2.37917
EIF6 eukaryotic translation initiation factor 6 2.35964
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.32218
LCN2 lipocalin 2 2.31986
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 2.23596
IER2 immediate early response 2 2.20801
KRT23 keratin 23, type I 2.18003
ZFP36 ZFP36 ring finger protein 2.17842
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.15684
S100A13 S100 calcium binding protein A13 2.12976
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.12151
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.10883
VAT1 vesicle amine transport 1 2.10367
CEP170 centrosomal protein 170kDa 2.09146
MMP24-AS1-EDEM2 MMP24-AS1-EDEM2 readthrough 2.08589
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.06691
FAT1 FAT atypical cadherin 1 2.0648
ACOT9 acyl-CoA thioesterase 9 2.05584
MFSD1 major facilitator superfamily domain containing 1 2.05453
DSG2 desmoglein 2 2.04412
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.03639
CRYZ crystallin, zeta (quinone reductase) 2.03159
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 2.02734

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -8.04999
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -7.63236
GNAS GNAS complex locus -7.09273
LDHD lactate dehydrogenase D -6.91137
CDC20 cell division cycle 20 -6.87069
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.73345
PSRC1 proline/serine-rich coiled-coil 1 -5.20491
PLK1 polo-like kinase 1 -4.90823
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -4.87068
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.64471
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.59121
CCNB2 cyclin B2 -4.58408
CDK1 cyclin-dependent kinase 1 -4.5241
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.41304
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -4.39132
ZDHHC6 zinc finger, DHHC-type containing 6 -4.06599
CCNA2 cyclin A2 -3.95843
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.84574
MYL9 myosin, light chain 9, regulatory -3.81578
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.77127
CCNB1 cyclin B1 -3.7436
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.70617
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.67232
TOP2A topoisomerase (DNA) II alpha 170kDa -3.48465
FAIM Fas apoptotic inhibitory molecule -3.34627
MELK maternal embryonic leucine zipper kinase -3.22617
PGM1 phosphoglucomutase 1 -3.039
TCTN1 tectonic family member 1 -3.00895
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.93526
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.895
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.87579
SOAT2 sterol O-acyltransferase 2 -2.72738
NCAPH non-SMC condensin I complex, subunit H -2.70305
PEG10 paternally expressed 10 -2.69664
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.66902
BIRC5 baculoviral IAP repeat containing 5 -2.64225
FGFR4 fibroblast growth factor receptor 4 -2.59028
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.55925
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.52125
AURKB aurora kinase B -2.52105
CHMP4B charged multivesicular body protein 4B -2.51612
HADH hydroxyacyl-CoA dehydrogenase -2.46973
STMN1 stathmin 1 -2.46706
GSTM2 glutathione S-transferase mu 2 (muscle) -2.443
KLHDC2 kelch domain containing 2 -2.3932
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.37598
CDO1 cysteine dioxygenase type 1 -2.37438
CDC25B cell division cycle 25B -2.36823
GPR6 G protein-coupled receptor 6 -2.36232
KRT36 keratin 36, type I -2.35141
CRELD2 cysteine-rich with EGF-like domains 2 -2.33116
YBX2 Y box binding protein 2 -2.32863
MIS18A MIS18 kinetochore protein A -2.30325
NCAPD2 non-SMC condensin I complex, subunit D2 -2.27114
FABP7 fatty acid binding protein 7, brain -2.26093
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.2382
ADI1 acireductone dioxygenase 1 -2.2243
ALDOC aldolase C, fructose-bisphosphate -2.22279
TMEM97 transmembrane protein 97 -2.22245
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.21083
MTMR10 myotubularin related protein 10 -2.1786
IL12A interleukin 12A -2.1779
KIFC1 kinesin family member C1 -2.16395
NR2E1 nuclear receptor subfamily 2, group E, member 1 -2.15557
SRI sorcin -2.14969
SCRG1 stimulator of chondrogenesis 1 -2.1472
CCNF cyclin F -2.14589
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.12973
HMG20B high mobility group 20B -2.12609
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 -2.10925
TDRD1 tudor domain containing 1 -2.10198
SS18L2 synovial sarcoma translocation gene on chromosome 18-like 2 -2.0851
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -2.07953
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 -2.07348
NCAPG2 non-SMC condensin II complex, subunit G2 -2.05955
CKB creatine kinase, brain -2.05487
HMGN2 high mobility group nucleosomal binding domain 2 -2.04577
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.03852
STK26 serine/threonine protein kinase 26 -2.03458
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.03105
GFM1 G elongation factor, mitochondrial 1 -2.02721
LBR lamin B receptor -2.01884
ATP8B3 ATPase, aminophospholipid transporter, class I, type 8B, member 3 -2.01635
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.01426
CD200R1 CD200 receptor 1 -2.01355
CLCN2 chloride channel, voltage-sensitive 2 -2.00401
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -2.00385