CRCGN010_HEPG2_24H:N20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 10.71 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:N20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.11348
SQOR sulfide quinone oxidoreductase 3.74666
STK10 serine/threonine kinase 10 3.61277
BLMH bleomycin hydrolase 3.55395
CHN1 chimerin 1 3.48153
NOTCH1 notch 1 3.42699
CXCL2 chemokine (C-X-C motif) ligand 2 3.23722
INPP1 inositol polyphosphate-1-phosphatase 3.17766
CSK c-src tyrosine kinase 3.09211
ATP11B ATPase, class VI, type 11B 3.01581
KLHL21 kelch-like family member 21 2.95484
CNPY3 canopy FGF signaling regulator 3 2.86504
IER3 immediate early response 3 2.58981
TUBB6 tubulin, beta 6 class V 2.54845
PRKCH protein kinase C, eta 2.54598
CHMP6 charged multivesicular body protein 6 2.53453
NPDC1 neural proliferation, differentiation and control, 1 2.50163
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 2.42968
STX1A syntaxin 1A (brain) 2.41406
PRR15L proline rich 15-like 2.40108
VGLL4 vestigial-like family member 4 2.33367
RPGR retinitis pigmentosa GTPase regulator 2.25117
RXYLT1 ribitol xylosyltransferase 1 2.22844
JADE2 jade family PHD finger 2 2.12747
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.04687
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.04141
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.01111

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.75406
CCNB2 cyclin B2 -6.55107
DERA deoxyribose-phosphate aldolase (putative) -4.17502
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.09137
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.97848
TRIB3 tribbles pseudokinase 3 -3.96277
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.80441
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.64819
RNF167 ring finger protein 167 -3.58122
FGFR4 fibroblast growth factor receptor 4 -3.45892
UBE3C ubiquitin protein ligase E3C -3.44944
ZDHHC6 zinc finger, DHHC-type containing 6 -3.37639
PCNA proliferating cell nuclear antigen -3.23468
ZMIZ1 zinc finger, MIZ-type containing 1 -3.20769
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.18577
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.18366
LDHD lactate dehydrogenase D -3.16749
PCCB propionyl CoA carboxylase, beta polypeptide -3.07675
CHMP4B charged multivesicular body protein 4B -3.05048
PTPRK protein tyrosine phosphatase, receptor type, K -2.90762
TSPAN4 tetraspanin 4 -2.8988
ACAA1 acetyl-CoA acyltransferase 1 -2.80298
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.7156
GOLT1B golgi transport 1B -2.60266
ZNF586 zinc finger protein 586 -2.58621
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -2.52354
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.39025
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.37371
DDIT4 DNA-damage-inducible transcript 4 -2.3702
NGRN neugrin, neurite outgrowth associated -2.30371
MSMO1 methylsterol monooxygenase 1 -2.25711
TMEM147 transmembrane protein 147 -2.18597
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.15011
OXA1L oxidase (cytochrome c) assembly 1-like -2.12228
TATDN2 TatD DNase domain containing 2 -2.07528
CDC25B cell division cycle 25B -2.00784