| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 5,7-dichloro-4-(4-fluorophenoxy)quinoline 2.68 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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55 genes differentially expressed following the CRCGN010_HEPG2_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PNKP | polynucleotide kinase 3'-phosphatase | 7.91768 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 7.36302 |
| CHN1 | chimerin 1 | 5.54746 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 4.51485 |
| STK10 | serine/threonine kinase 10 | 3.77078 |
| ADRB2 | adrenoceptor beta 2, surface | 3.53252 |
| TREM1 | triggering receptor expressed on myeloid cells 1 | 3.12874 |
| LCN2 | lipocalin 2 | 3.07355 |
| TXNL4B | thioredoxin-like 4B | 2.98297 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.71781 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.55683 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.52625 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.37224 |
| DFFB | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) | 2.35974 |
| TBXA2R | thromboxane A2 receptor | 2.33419 |
| CSK | c-src tyrosine kinase | 2.27507 |
| ADA | adenosine deaminase | 2.22261 |
| BIRC2 | baculoviral IAP repeat containing 2 | 2.16946 |
| TRIM13 | tripartite motif containing 13 | 2.16911 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.13445 |
| MAP7 | microtubule-associated protein 7 | 2.1252 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.11156 |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 2.06733 |
| AP1B1 | adaptor-related protein complex 1, beta 1 subunit | 2.04657 |
| CNN3 | calponin 3, acidic | 2.01581 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.00236 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -6.44978 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.22257 |
| TRIB3 | tribbles pseudokinase 3 | -5.09645 |
| UBE3C | ubiquitin protein ligase E3C | -5.06864 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -4.85435 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -4.5963 |
| NGRN | neugrin, neurite outgrowth associated | -3.81667 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -3.45569 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -3.01883 |
| TCTN1 | tectonic family member 1 | -3.01109 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.91379 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -2.57689 |
| CDC25B | cell division cycle 25B | -2.49265 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.45521 |
| USP6NL | USP6 N-terminal like | -2.4266 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -2.4257 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -2.22177 |
| ZNF586 | zinc finger protein 586 | -2.214 |
| SPAG7 | sperm associated antigen 7 | -2.18136 |
| GNAS | GNAS complex locus | -2.15367 |
| HMG20B | high mobility group 20B | -2.14828 |
| TLR4 | toll-like receptor 4 | -2.08875 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | -2.08512 |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A | -2.08298 |
| PCNA | proliferating cell nuclear antigen | -2.05377 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.04267 |
| WASHC4 | WASH complex subunit 4 | -2.03777 |
| TM9SF2 | transmembrane 9 superfamily member 2 | -2.03242 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -2.01952 |
