| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-phenylazo-2-naphthol 40.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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246 genes differentially expressed following the CRCGN010_HEPG2_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 9.86136 |
| ABHD4 | abhydrolase domain containing 4 | 9.67338 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 9.64854 |
| HMOX1 | heme oxygenase 1 | 9.22777 |
| RAP1GAP | RAP1 GTPase activating protein | 8.40392 |
| ZFP36 | ZFP36 ring finger protein | 6.38058 |
| SQSTM1 | sequestosome 1 | 6.32447 |
| INPP1 | inositol polyphosphate-1-phosphatase | 6.18808 |
| CBR1 | carbonyl reductase 1 | 5.95092 |
| KEAP1 | kelch-like ECH-associated protein 1 | 5.91989 |
| FOSL1 | FOS-like antigen 1 | 5.78656 |
| MVP | major vault protein | 5.6051 |
| AXIN1 | axin 1 | 5.58731 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 5.3868 |
| NUCB2 | nucleobindin 2 | 5.37911 |
| SFTPB | surfactant protein B | 5.02366 |
| CYCS | cytochrome c, somatic | 4.92802 |
| PNKP | polynucleotide kinase 3'-phosphatase | 4.71613 |
| MAP7 | microtubule-associated protein 7 | 4.61667 |
| CTSL | cathepsin L | 4.58973 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 4.56883 |
| HSPA1A | heat shock 70kDa protein 1A | 4.55733 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 4.54407 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 4.25872 |
| STAP2 | signal transducing adaptor family member 2 | 4.24109 |
| SQOR | sulfide quinone oxidoreductase | 4.22014 |
| GPC1 | glypican 1 | 4.12353 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 4.10948 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.95472 |
| CHN1 | chimerin 1 | 3.89228 |
| JADE2 | jade family PHD finger 2 | 3.83297 |
| TMEM50A | transmembrane protein 50A | 3.82088 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.73184 |
| NANOS3 | nanos homolog 3 (Drosophila) | 3.68039 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 3.67307 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.66565 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 3.55491 |
| CHMP6 | charged multivesicular body protein 6 | 3.52605 |
| CCDC92 | coiled-coil domain containing 92 | 3.41855 |
| STX4 | syntaxin 4 | 3.41465 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.40765 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.35811 |
| LCN2 | lipocalin 2 | 3.35329 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 3.29233 |
| SORBS3 | sorbin and SH3 domain containing 3 | 3.26491 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.2022 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 3.19794 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 3.13219 |
| UBQLN2 | ubiquilin 2 | 3.12152 |
| MICALL1 | MICAL-like 1 | 3.09284 |
| KLHL21 | kelch-like family member 21 | 3.0104 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.97082 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.92541 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.91129 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 2.90059 |
| SLC67A1 | solute carrier family 67 member 1 | 2.89052 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.85228 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 2.8223 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.75286 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.70224 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.68704 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.67328 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.6728 |
| SLC75A1 | solute carrier family 75 member 1 | 2.61886 |
| PRKCD | protein kinase C, delta | 2.58492 |
| RAB5IF | RAB5 interacting factor | 2.58031 |
| NECAP1 | NECAP endocytosis associated 1 | 2.56478 |
| CDC25B | cell division cycle 25B | 2.56112 |
| SCPEP1 | serine carboxypeptidase 1 | 2.54224 |
| ATG9A | autophagy related 9A | 2.52034 |
| HMG20B | high mobility group 20B | 2.51602 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.49747 |
| TPRA1 | transmembrane protein, adipocyte asscociated 1 | 2.49268 |
| RRAGA | Ras-related GTP binding A | 2.4908 |
| STX1A | syntaxin 1A (brain) | 2.48531 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.46281 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.45054 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 2.44931 |
| ZNF451 | zinc finger protein 451 | 2.41901 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.41691 |
| TRAPPC3 | trafficking protein particle complex 3 | 2.41118 |
| UGT1A10 | UDP glucuronosyltransferase 1 family, polypeptide A10 | 2.40209 |
| ANKRD10 | ankyrin repeat domain 10 | 2.39916 |
| COG2 | component of oligomeric golgi complex 2 | 2.39722 |
| MCM3 | minichromosome maintenance complex component 3 | 2.39366 |
| ATG3 | autophagy related 3 | 2.39125 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.37606 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 2.37408 |
| RGCC | regulator of cell cycle | 2.35925 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 2.35275 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.31216 |
| HABP4 | hyaluronan binding protein 4 | 2.30697 |
| CRTC3 | CREB regulated transcription coactivator 3 | 2.30331 |
| BLMH | bleomycin hydrolase | 2.28056 |
| MAPK13 | mitogen-activated protein kinase 13 | 2.2703 |
| NCOA6 | nuclear receptor coactivator 6 | 2.25567 |
| TSKU | tsukushi, small leucine rich proteoglycan | 2.23069 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.22892 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 2.22415 |
| HSPA1B | heat shock 70kDa protein 1B | 2.21764 |
| SFXN3 | sideroflexin 3 | 2.18943 |
| LTBR | lymphotoxin beta receptor (TNFR superfamily, member 3) | 2.18641 |
| MCCC1 | methylcrotonoyl-CoA carboxylase 1 (alpha) | 2.17402 |
| NMU | neuromedin U | 2.15116 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.14117 |
| LOC122526780 | uncharacterized LOC122526780 | 2.128 |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase | 2.11683 |
| ZNF768 | zinc finger protein 768 | 2.10432 |
| LOXL1 | lysyl oxidase-like 1 | 2.10365 |
| GPHRA | golgi pH regulator A | 2.08003 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | 2.07657 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 2.07137 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.0704 |
| H2BC12 | H2B clustered histone 12 | 2.05745 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.05627 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.03825 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 2.03384 |
| CYTH1 | cytohesin 1 | 2.02303 |
| TSR3 | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae) | 2.01486 |
| FOXJ3 | forkhead box J3 | 2.01351 |
| GPR87 | G protein-coupled receptor 87 | 2.0071 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -9.53178 |
| ZNF586 | zinc finger protein 586 | -8.79107 |
| CDC20 | cell division cycle 20 | -7.93428 |
| FGFR4 | fibroblast growth factor receptor 4 | -7.75477 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -7.46631 |
| TCTN1 | tectonic family member 1 | -7.26275 |
| MELK | maternal embryonic leucine zipper kinase | -6.81368 |
| PEG10 | paternally expressed 10 | -6.70376 |
| AURKB | aurora kinase B | -6.37382 |
| ISOC1 | isochorismatase domain containing 1 | -5.86252 |
| CDK1 | cyclin-dependent kinase 1 | -5.68063 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -5.61861 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -5.56304 |
| ALDOC | aldolase C, fructose-bisphosphate | -5.10541 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -5.09815 |
| HMGA2 | high mobility group AT-hook 2 | -5.05551 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -4.9773 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -4.87144 |
| CCNB2 | cyclin B2 | -4.86951 |
| SOAT2 | sterol O-acyltransferase 2 | -4.81934 |
| CCNA2 | cyclin A2 | -4.77911 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -4.7307 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -4.49893 |
| STMN1 | stathmin 1 | -4.26598 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -4.24299 |
| PLK1 | polo-like kinase 1 | -4.20096 |
| C5 | complement component 5 | -4.19925 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -4.09163 |
| VDAC1 | voltage-dependent anion channel 1 | -4.05671 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -3.97557 |
| HAT1 | histone acetyltransferase 1 | -3.96908 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.95417 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.89857 |
| PCNA | proliferating cell nuclear antigen | -3.88936 |
| DCK | deoxycytidine kinase | -3.87254 |
| SMC4 | structural maintenance of chromosomes 4 | -3.78064 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -3.76028 |
| NUP85 | nucleoporin 85kDa | -3.59057 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.44174 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.43186 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -3.41057 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.39287 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.36004 |
| PGAM4 | phosphoglycerate mutase family member 4 | -3.31815 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.31034 |
| TLR4 | toll-like receptor 4 | -3.30272 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -3.28168 |
| LDHD | lactate dehydrogenase D | -3.27747 |
| KIF14 | kinesin family member 14 | -3.17288 |
| CHMP4B | charged multivesicular body protein 4B | -3.14441 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -3.05947 |
| PGM1 | phosphoglucomutase 1 | -2.86965 |
| S100A1 | S100 calcium binding protein A1 | -2.8579 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -2.85334 |
| ENOPH1 | enolase-phosphatase 1 | -2.83333 |
| FAT1 | FAT atypical cadherin 1 | -2.82867 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -2.81131 |
| KIF4A | kinesin family member 4A | -2.73132 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.72909 |
| ZWILCH | zwilch kinetochore protein | -2.72589 |
| PROS1 | protein S (alpha) | -2.71639 |
| LBR | lamin B receptor | -2.70453 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -2.65561 |
| FANCG | Fanconi anemia, complementation group G | -2.63409 |
| S100A4 | S100 calcium binding protein A4 | -2.62791 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -2.57141 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -2.55146 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -2.54526 |
| INTS3 | integrator complex subunit 3 | -2.53563 |
| KIF2C | kinesin family member 2C | -2.5013 |
| TMEM97 | transmembrane protein 97 | -2.48659 |
| ZNF134 | zinc finger protein 134 | -2.48432 |
| FBXO5 | F-box protein 5 | -2.47327 |
| KIF11 | kinesin family member 11 | -2.47022 |
| PDLIM1 | PDZ and LIM domain 1 | -2.46021 |
| PEG3 | paternally expressed 3 | -2.45499 |
| IER3 | immediate early response 3 | -2.45473 |
| CDCA8 | cell division cycle associated 8 | -2.45092 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.43641 |
| KIF15 | kinesin family member 15 | -2.43004 |
| PRPF4 | pre-mRNA processing factor 4 | -2.42289 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.41329 |
| ASF1B | anti-silencing function 1B histone chaperone | -2.41124 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -2.40841 |
| ICAM1 | intercellular adhesion molecule 1 | -2.32943 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -2.30639 |
| HMGB2 | high mobility group box 2 | -2.28035 |
| ZWINT | ZW10 interacting kinetochore protein | -2.27936 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -2.26764 |
| CENPM | centromere protein M | -2.25127 |
| VASH2 | vasohibin 2 | -2.24779 |
| TSPAN12 | tetraspanin 12 | -2.24085 |
| TPM1 | tropomyosin 1 (alpha) | -2.23972 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.23114 |
| MYLK | myosin light chain kinase | -2.23103 |
| NUDT15 | nudix (nucleoside diphosphate linked moiety X)-type motif 15 | -2.22531 |
| MCM10 | minichromosome maintenance complex component 10 | -2.2166 |
| USP1 | ubiquitin specific peptidase 1 | -2.20777 |
| MYO10 | myosin X | -2.20725 |
| SNX11 | sorting nexin 11 | -2.19742 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.19662 |
| WASHC4 | WASH complex subunit 4 | -2.19354 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.18742 |
| MIS18A | MIS18 kinetochore protein A | -2.18643 |
| ENO3 | enolase 3 (beta, muscle) | -2.17123 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -2.1573 |
| VAV3 | vav 3 guanine nucleotide exchange factor | -2.15208 |
| HJURP | Holliday junction recognition protein | -2.14805 |
| DENND2D | DENN/MADD domain containing 2D | -2.14051 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -2.1356 |
| CCNB1 | cyclin B1 | -2.13408 |
| RPS5 | ribosomal protein S5 | -2.10399 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -2.10272 |
| MSMO1 | methylsterol monooxygenase 1 | -2.09047 |
| SGCE | sarcoglycan, epsilon | -2.08547 |
| MSH6 | mutS homolog 6 | -2.07298 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -2.06278 |
| FEN1 | flap structure-specific endonuclease 1 | -2.04995 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -2.03105 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) | -2.0237 |
| RNF38 | ring finger protein 38 | -2.02368 |
| CNTLN | centlein, centrosomal protein | -2.02314 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | -2.01824 |
| FRAT2 | frequently rearranged in advanced T-cell lymphomas 2 | -2.00986 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | -2.00304 |
