| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 1-phenylazo-2-naphthol 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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185 genes differentially expressed following the CRCGN010_HEPG2_24H:O08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 9.99565 |
| HMOX1 | heme oxygenase 1 | 9.32291 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 9.29818 |
| ABHD4 | abhydrolase domain containing 4 | 8.68208 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 8.05007 |
| RAP1GAP | RAP1 GTPase activating protein | 7.89457 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 7.02353 |
| SQSTM1 | sequestosome 1 | 6.94342 |
| UGDH | UDP-glucose 6-dehydrogenase | 6.55672 |
| FOSL1 | FOS-like antigen 1 | 6.40007 |
| KEAP1 | kelch-like ECH-associated protein 1 | 6.38038 |
| ZFP36 | ZFP36 ring finger protein | 6.02361 |
| NUCB2 | nucleobindin 2 | 5.85975 |
| PNKP | polynucleotide kinase 3'-phosphatase | 5.53528 |
| CBR1 | carbonyl reductase 1 | 4.6816 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 4.64362 |
| MVP | major vault protein | 4.54374 |
| SQOR | sulfide quinone oxidoreductase | 4.27269 |
| INPP1 | inositol polyphosphate-1-phosphatase | 4.15878 |
| PSMB10 | proteasome (prosome, macropain) subunit, beta type, 10 | 4.15272 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.98082 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 3.92452 |
| KLHL21 | kelch-like family member 21 | 3.69226 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 3.54182 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 3.48924 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 3.46902 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.44786 |
| TALDO1 | transaldolase 1 | 3.39834 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 3.38917 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.38847 |
| LCN2 | lipocalin 2 | 3.35925 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.31621 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 3.27489 |
| HSPA1A | heat shock 70kDa protein 1A | 3.21969 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 3.18469 |
| TMEM50A | transmembrane protein 50A | 3.18334 |
| CSK | c-src tyrosine kinase | 3.16448 |
| NANOS3 | nanos homolog 3 (Drosophila) | 3.15078 |
| HEBP1 | heme binding protein 1 | 3.14121 |
| SFTPB | surfactant protein B | 3.11523 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 3.09001 |
| SMAD3 | SMAD family member 3 | 3.06795 |
| ANO10 | anoctamin 10 | 3.02117 |
| CDC25B | cell division cycle 25B | 2.98621 |
| GSR | glutathione reductase | 2.90233 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.8475 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 2.82991 |
| CDC45 | cell division cycle 45 | 2.74888 |
| TRIM16 | tripartite motif containing 16 | 2.71542 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 2.70711 |
| PRKCD | protein kinase C, delta | 2.70037 |
| BAG3 | BCL2-associated athanogene 3 | 2.69511 |
| GPC1 | glypican 1 | 2.65926 |
| SLC67A1 | solute carrier family 67 member 1 | 2.64671 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 2.62277 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2.62128 |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 2.61748 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.60277 |
| H2BC12 | H2B clustered histone 12 | 2.60019 |
| MINDY1 | MINDY lysine 48 deubiquitinase 1 | 2.54349 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.53574 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 2.5141 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | 2.47278 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 2.42826 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 2.4075 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 2.40485 |
| AXIN1 | axin 1 | 2.39718 |
| CHN1 | chimerin 1 | 2.37234 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.29061 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.2853 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.27299 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.26627 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.19936 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.17549 |
| CHPF2 | chondroitin polymerizing factor 2 | 2.17036 |
| ATG3 | autophagy related 3 | 2.16914 |
| RAB11FIP5 | RAB11 family interacting protein 5 (class I) | 2.16255 |
| TRAPPC3 | trafficking protein particle complex 3 | 2.15407 |
| HSD17B14 | hydroxysteroid (17-beta) dehydrogenase 14 | 2.1364 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 2.12477 |
| POPDC3 | popeye domain containing 3 | 2.12335 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | 2.09126 |
| WDR91 | WD repeat domain 91 | 2.08478 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.0831 |
| STX1A | syntaxin 1A (brain) | 2.08057 |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | 2.07306 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 2.04186 |
| DIPK1A | divergent protein kinase domain 1A | 2.03951 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.03812 |
| TEX10 | testis expressed 10 | 2.00145 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -9.82632 |
| CDC20 | cell division cycle 20 | -7.26674 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -6.96383 |
| AURKB | aurora kinase B | -6.93597 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -6.50238 |
| MELK | maternal embryonic leucine zipper kinase | -6.29825 |
| TCTN1 | tectonic family member 1 | -6.20966 |
| CDK1 | cyclin-dependent kinase 1 | -5.19829 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -5.14579 |
| FGFR4 | fibroblast growth factor receptor 4 | -4.92399 |
| CCNB2 | cyclin B2 | -4.75734 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -4.5987 |
| ISOC1 | isochorismatase domain containing 1 | -4.46943 |
| CCNA2 | cyclin A2 | -4.39846 |
| HMGA2 | high mobility group AT-hook 2 | -4.36944 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -4.35231 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -4.28877 |
| PCNA | proliferating cell nuclear antigen | -4.17997 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -4.17825 |
| LAP3 | leucine aminopeptidase 3 | -4.11644 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -4.06777 |
| HAT1 | histone acetyltransferase 1 | -4.05976 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -4.04833 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -3.89851 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.83461 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.73581 |
| PCCB | propionyl CoA carboxylase, beta polypeptide | -3.72461 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.71895 |
| C5 | complement component 5 | -3.64703 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -3.62179 |
| PLK1 | polo-like kinase 1 | -3.5914 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.58488 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -3.541 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.53859 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.50682 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | -3.49421 |
| TLR4 | toll-like receptor 4 | -3.45893 |
| SOAT2 | sterol O-acyltransferase 2 | -3.43097 |
| NUP85 | nucleoporin 85kDa | -3.40687 |
| USP1 | ubiquitin specific peptidase 1 | -3.26715 |
| CCNB1 | cyclin B1 | -3.23344 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -3.18131 |
| THAP11 | THAP domain containing 11 | -3.14632 |
| ALDOC | aldolase C, fructose-bisphosphate | -3.05841 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -3.04229 |
| NGRN | neugrin, neurite outgrowth associated | -3.01973 |
| EDN1 | endothelin 1 | -3.01497 |
| KIF14 | kinesin family member 14 | -2.90475 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -2.83918 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -2.75282 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.74516 |
| MTFR1 | mitochondrial fission regulator 1 | -2.70649 |
| TES | testin LIM domain protein | -2.69364 |
| S100A4 | S100 calcium binding protein A4 | -2.68812 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -2.67079 |
| CENPE | centromere protein E, 312kDa | -2.61421 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.55529 |
| ENOPH1 | enolase-phosphatase 1 | -2.54661 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.51749 |
| MYL9 | myosin, light chain 9, regulatory | -2.49473 |
| ICAM1 | intercellular adhesion molecule 1 | -2.45738 |
| STMN1 | stathmin 1 | -2.45371 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -2.45064 |
| USP6NL | USP6 N-terminal like | -2.42239 |
| DNM1L | dynamin 1-like | -2.37578 |
| APOM | apolipoprotein M | -2.35511 |
| AURKA | aurora kinase A | -2.35199 |
| SMC4 | structural maintenance of chromosomes 4 | -2.33717 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -2.31749 |
| LYZ | lysozyme | -2.30189 |
| MYLK | myosin light chain kinase | -2.27944 |
| KIF4A | kinesin family member 4A | -2.26962 |
| KIF15 | kinesin family member 15 | -2.2375 |
| CHEK2 | checkpoint kinase 2 | -2.22601 |
| ZNF274 | zinc finger protein 274 | -2.22549 |
| FBXO5 | F-box protein 5 | -2.22355 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -2.19706 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | -2.15633 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -2.15569 |
| SETD6 | SET domain containing 6 | -2.15396 |
| HOXB9 | homeobox B9 | -2.14364 |
| GNAS | GNAS complex locus | -2.13184 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -2.11785 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -2.1056 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.09426 |
| SERPINA7 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 | -2.08969 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.0469 |
| TM4SF5 | transmembrane 4 L six family member 5 | -2.03904 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -2.03458 |
| MSMO1 | methylsterol monooxygenase 1 | -2.03008 |
| LYPLA1 | lysophospholipase I | -2.02898 |
| DSCC1 | DNA replication and sister chromatid cohesion 1 | -2.02726 |
| COG7 | component of oligomeric golgi complex 7 | -2.00809 |
| A1CF | APOBEC1 complementation factor | -2.00606 |
| TERT | telomerase reverse transcriptase | -2.00539 |
