CRCGN010_HEPG2_24H:O09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenylazo-2-naphthol 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

241 genes differentially expressed following the CRCGN010_HEPG2_24H:O09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 10.0
UBQLN2 ubiquilin 2 10.0
HMOX1 heme oxygenase 1 9.10843
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 9.01953
ABHD4 abhydrolase domain containing 4 8.8249
RAP1GAP RAP1 GTPase activating protein 7.15781
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 7.15724
CHMP6 charged multivesicular body protein 6 6.5919
KEAP1 kelch-like ECH-associated protein 1 6.47364
SQSTM1 sequestosome 1 6.23501
CCNA1 cyclin A1 5.56277
MAP7 microtubule-associated protein 7 5.50458
PRKCQ protein kinase C, theta 5.42494
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 5.37009
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.09808
CEMIP2 cell migration inducing hyaluronidase 2 5.07999
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.75555
PPARG peroxisome proliferator-activated receptor gamma 4.72234
CTSL cathepsin L 4.66774
ZFP36 ZFP36 ring finger protein 4.57377
MVP major vault protein 4.513
KLHL21 kelch-like family member 21 4.44935
FOSL1 FOS-like antigen 1 4.41669
KIFBP kinesin family binding protein 4.25742
CBR1 carbonyl reductase 1 4.08202
C2CD2 C2 calcium-dependent domain containing 2 4.05904
SQOR sulfide quinone oxidoreductase 4.041
TEX10 testis expressed 10 3.98768
CGRRF1 cell growth regulator with ring finger domain 1 3.93558
ADGRE5 adhesion G protein-coupled receptor E5 3.85163
IKZF1 IKAROS family zinc finger 1 (Ikaros) 3.79982
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.78473
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.76611
ALAS1 5'-aminolevulinate synthase 1 3.75133
NUCB2 nucleobindin 2 3.7291
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.68459
IDE insulin-degrading enzyme 3.67174
DYNLT3 dynein, light chain, Tctex-type 3 3.59709
H2BC12 H2B clustered histone 12 3.58899
ZNF589 zinc finger protein 589 3.56352
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.46001
ANO1 anoctamin 1, calcium activated chloride channel 3.32712
RPP38 ribonuclease P/MRP 38kDa subunit 3.20505
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.14028
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.08032
GCLM glutamate-cysteine ligase, modifier subunit 3.05894
CDC25B cell division cycle 25B 3.03568
GLRX glutaredoxin (thioltransferase) 2.93784
NOTCH1 notch 1 2.91925
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.90262
GCLC glutamate-cysteine ligase, catalytic subunit 2.85452
SMIM40 small integral membrane protein 40 2.81251
CRYZ crystallin, zeta (quinone reductase) 2.78671
CHN1 chimerin 1 2.76529
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.75032
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.73673
LSR lipolysis stimulated lipoprotein receptor 2.71843
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.67226
NPDC1 neural proliferation, differentiation and control, 1 2.66596
INPP1 inositol polyphosphate-1-phosphatase 2.65423
ANO10 anoctamin 10 2.6505
PIR pirin (iron-binding nuclear protein) 2.64168
RAB9A RAB9A, member RAS oncogene family 2.63753
PEX11A peroxisomal biogenesis factor 11 alpha 2.63132
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.61324
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.6008
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.56703
PELO pelota homolog (Drosophila) 2.53932
CYTH1 cytohesin 1 2.52968
DAAM2 dishevelled associated activator of morphogenesis 2 2.49855
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 2.46768
DUSP6 dual specificity phosphatase 6 2.43218
TFE3 transcription factor binding to IGHM enhancer 3 2.42162
EPHA3 EPH receptor A3 2.42133
TMEM50A transmembrane protein 50A 2.42061
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.41249
TXNL4B thioredoxin-like 4B 2.40342
NANOS3 nanos homolog 3 (Drosophila) 2.39724
GBP2 guanylate binding protein 2, interferon-inducible 2.38558
PRKCD protein kinase C, delta 2.3689
GATA3 GATA binding protein 3 2.36229
TM9SF2 transmembrane 9 superfamily member 2 2.32171
CTTN cortactin 2.31299
ATF3 activating transcription factor 3 2.30113
MTERF3 mitochondrial transcription termination factor 3 2.29476
CSK c-src tyrosine kinase 2.29191
STAB1 stabilin 1 2.28911
STX4 syntaxin 4 2.28275
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.27368
LGALSL lectin, galactoside-binding-like 2.23466
RAB21 RAB21, member RAS oncogene family 2.23184
OFD1 oral-facial-digital syndrome 1 2.22708
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.2238
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.22309
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.20769
DMTF1 cyclin D binding myb-like transcription factor 1 2.20578
OSGIN1 oxidative stress induced growth inhibitor 1 2.20458
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.19964
CTSW cathepsin W 2.19222
TRIM16 tripartite motif containing 16 2.14962
ZFAND5 zinc finger, AN1-type domain 5 2.14445
NQO1 NAD(P)H dehydrogenase, quinone 1 2.11086
PHKB phosphorylase kinase, beta 2.11037
CNPY3 canopy FGF signaling regulator 3 2.10908
RBKS ribokinase 2.10847
CTAGE8 CTAGE family, member 8 2.10249
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.1014
CDC45 cell division cycle 45 2.0949
ADA adenosine deaminase 2.09197
KCTD9 potassium channel tetramerization domain containing 9 2.09005
CD40 CD40 molecule, TNF receptor superfamily member 5 2.08061
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 2.07457
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 2.04543
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.03937
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.03688
STAT4 signal transducer and activator of transcription 4 2.02817
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2.00016

decreased expression

Symbol Name Standardized Value
PSRC1 proline/serine-rich coiled-coil 1 -8.03512
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -7.8421
CCNB2 cyclin B2 -7.13439
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -6.7345
OXA1L oxidase (cytochrome c) assembly 1-like -6.36272
CDC20 cell division cycle 20 -6.33398
AURKB aurora kinase B -5.68498
TCTN1 tectonic family member 1 -5.17447
FGFR4 fibroblast growth factor receptor 4 -5.04995
HMGA2 high mobility group AT-hook 2 -5.02022
UBE2C ubiquitin-conjugating enzyme E2C -4.63807
GNAS GNAS complex locus -4.62346
CDK1 cyclin-dependent kinase 1 -4.61235
B4GAT1 beta-1,4-glucuronyltransferase 1 -4.52868
THAP11 THAP domain containing 11 -4.05305
DSG2 desmoglein 2 -4.04463
GTPBP8 GTP-binding protein 8 (putative) -4.03377
CCNA2 cyclin A2 -3.91322
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.87503
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.80049
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.79502
PEG10 paternally expressed 10 -3.69673
MYL9 myosin, light chain 9, regulatory -3.68492
C5 complement component 5 -3.63662
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.58615
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.54009
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.53062
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.45762
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -3.40347
PLK1 polo-like kinase 1 -3.39579
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.33956
CD320 CD320 molecule -3.31074
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.20515
GLOD4 glyoxalase domain containing 4 -3.13889
STMN1 stathmin 1 -3.13386
LDHD lactate dehydrogenase D -3.10788
C2CD5 C2 calcium-dependent domain containing 5 -3.0969
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.066
PECR peroxisomal trans-2-enoyl-CoA reductase -3.04701
ERBB2 erb-b2 receptor tyrosine kinase 2 -3.006
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.99565
IFITM3 interferon induced transmembrane protein 3 -2.92386
ISOC1 isochorismatase domain containing 1 -2.91771
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.87498
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.87342
SOAT2 sterol O-acyltransferase 2 -2.84535
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -2.84307
TOP2A topoisomerase (DNA) II alpha 170kDa -2.84107
EDN1 endothelin 1 -2.83754
FBXL12 F-box and leucine-rich repeat protein 12 -2.831
AURKA aurora kinase A -2.8119
KIF14 kinesin family member 14 -2.80447
RFC2 replication factor C (activator 1) 2, 40kDa -2.78736
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.75734
BIRC5 baculoviral IAP repeat containing 5 -2.70599
USP6NL USP6 N-terminal like -2.70464
PPOX protoporphyrinogen oxidase -2.70294
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) -2.69968
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.61942
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.61811
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.57027
ARID3A AT rich interactive domain 3A (BRIGHT-like) -2.52706
PCCB propionyl CoA carboxylase, beta polypeptide -2.5184
FANCG Fanconi anemia, complementation group G -2.51532
TLR4 toll-like receptor 4 -2.49944
CHMP4B charged multivesicular body protein 4B -2.49468
MYO10 myosin X -2.48009
ARID5B AT rich interactive domain 5B (MRF1-like) -2.45679
HMGN1 high mobility group nucleosome binding domain 1 -2.44902
HAT1 histone acetyltransferase 1 -2.43914
NUDCD3 NudC domain containing 3 -2.43273
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.42562
ICAM3 intercellular adhesion molecule 3 -2.40559
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.40528
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.40349
YME1L1 YME1-like 1 ATPase -2.39889
IFITM2 interferon induced transmembrane protein 2 -2.38404
PRPF4 pre-mRNA processing factor 4 -2.36394
TMEM258 transmembrane protein 258 -2.35601
DNAI7 dynein axonemal intermediate chain 7 -2.31338
ZMIZ1 zinc finger, MIZ-type containing 1 -2.30653
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) -2.29945
FBXO5 F-box protein 5 -2.29578
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.25675
RIBC2 RIB43A domain with coiled-coils 2 -2.25498
CS citrate synthase -2.23958
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -2.23851
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.22341
PGM1 phosphoglucomutase 1 -2.2219
ENOPH1 enolase-phosphatase 1 -2.2194
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -2.21883
TMEM97 transmembrane protein 97 -2.1863
NUP85 nucleoporin 85kDa -2.17799
TPPP3 tubulin polymerization-promoting protein family member 3 -2.16905
NCAPD2 non-SMC condensin I complex, subunit D2 -2.16652
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -2.16637
E2F8 E2F transcription factor 8 -2.13667
MYH10 myosin, heavy chain 10, non-muscle -2.13537
ICAM1 intercellular adhesion molecule 1 -2.11947
OXCT1 3-oxoacid CoA transferase 1 -2.114
ALDOC aldolase C, fructose-bisphosphate -2.11094
HRC histidine rich calcium binding protein -2.10885
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.10583
CCNF cyclin F -2.09469
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 -2.0925
UBTD1 ubiquitin domain containing 1 -2.08782
MAPT microtubule-associated protein tau -2.08614
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -2.07793
NNT nicotinamide nucleotide transhydrogenase -2.07515
S100A4 S100 calcium binding protein A4 -2.07042
EPCIP exosomal polycystin 1 interacting protein -2.06532
IMPACT impact RWD domain protein -2.06087
E2F5 E2F transcription factor 5, p130-binding -2.05659
TTK TTK protein kinase -2.05111
ZC3H4 zinc finger CCCH-type containing 4 -2.04715
CCNO cyclin O -2.04243
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.03127
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.03042
PIMREG PICALM interacting mitotic regulator -2.0196
HMGN2 high mobility group nucleosomal binding domain 2 -2.0121
LOC124900193 uncharacterized LOC124900193 -2.00929
PSKH1 protein serine kinase H1 -2.00717
HOXA6 homeobox A6 -2.00447
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -2.00247