CRCGN010_HEPG2_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenylazo-2-naphthol 5.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

225 genes differentially expressed following the CRCGN010_HEPG2_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 10.0
HMOX1 heme oxygenase 1 9.1071
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 8.82357
CTSL cathepsin L 8.57051
ABHD4 abhydrolase domain containing 4 7.37397
SQSTM1 sequestosome 1 6.76204
RAP1GAP RAP1 GTPase activating protein 6.49944
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 6.38666
VAT1 vesicle amine transport 1 6.29016
ZFP36 ZFP36 ring finger protein 6.25379
UGDH UDP-glucose 6-dehydrogenase 5.9402
KEAP1 kelch-like ECH-associated protein 1 5.7141
GSTZ1 glutathione S-transferase zeta 1 5.69298
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.85957
MVP major vault protein 4.54991
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 4.54449
NOSIP nitric oxide synthase interacting protein 4.3502
PPARG peroxisome proliferator-activated receptor gamma 4.27733
NUCB2 nucleobindin 2 4.02805
RPP38 ribonuclease P/MRP 38kDa subunit 4.01955
SQOR sulfide quinone oxidoreductase 3.9782
ALAS1 5'-aminolevulinate synthase 1 3.90062
CBR1 carbonyl reductase 1 3.83966
FOSL1 FOS-like antigen 1 3.8303
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.7517
TEX10 testis expressed 10 3.74407
CHMP6 charged multivesicular body protein 6 3.58338
LPAR2 lysophosphatidic acid receptor 2 3.575
CGRRF1 cell growth regulator with ring finger domain 1 3.44535
STK10 serine/threonine kinase 10 3.44334
SLC75A1 solute carrier family 75 member 1 3.37898
CARMIL1 capping protein regulator and myosin 1 linker 1 3.36867
LCN2 lipocalin 2 3.31389
PNKP polynucleotide kinase 3'-phosphatase 3.20515
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 3.16545
KLHL21 kelch-like family member 21 3.13457
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.07078
PXMP2 peroxisomal membrane protein 2, 22kDa 3.04036
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.99707
BAG3 BCL2-associated athanogene 3 2.9745
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.96679
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.94287
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.91334
TMEM50A transmembrane protein 50A 2.90172
CXCR4 chemokine (C-X-C motif) receptor 4 2.89642
H2BC12 H2B clustered histone 12 2.88457
NANOS3 nanos homolog 3 (Drosophila) 2.8791
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.83022
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 2.82606
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 2.80437
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.7879
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.75559
CIAO3 cytosolic iron-sulfur assembly component 3 2.74736
EVL Enah/Vasp-like 2.73142
TPRA1 transmembrane protein, adipocyte asscociated 1 2.69627
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.65959
STX1A syntaxin 1A (brain) 2.63026
STX4 syntaxin 4 2.61759
SMAD3 SMAD family member 3 2.56948
MOK MOK protein kinase 2.53725
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.53023
HSPA1A heat shock 70kDa protein 1A 2.52423
AXIN1 axin 1 2.50671
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.50329
CDC45 cell division cycle 45 2.4562
UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 2.45325
AMDHD2 amidohydrolase domain containing 2 2.43256
INPP1 inositol polyphosphate-1-phosphatase 2.42984
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.42499
KCNK1 potassium channel, two pore domain subfamily K, member 1 2.42499
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.41724
ATP11B ATPase, class VI, type 11B 2.40886
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.38928
NMU neuromedin U 2.30777
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.2748
BLMH bleomycin hydrolase 2.24792
PRKCD protein kinase C, delta 2.24459
RNF103 ring finger protein 103 2.23418
CRYZ crystallin, zeta (quinone reductase) 2.22603
ABHD6 abhydrolase domain containing 6 2.22322
DUSP6 dual specificity phosphatase 6 2.21398
TWF2 twinfilin actin binding protein 2 2.21142
ANXA5 annexin A5 2.21089
HMG20B high mobility group 20B 2.20144
LHFPL2 lipoma HMGIC fusion partner-like 2 2.19979
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.19611
ISG15 ISG15 ubiquitin-like modifier 2.19606
FCHO1 FCH domain only 1 2.19385
GCLC glutamate-cysteine ligase, catalytic subunit 2.18308
AKR1C1 aldo-keto reductase family 1, member C1 2.177
CDC25B cell division cycle 25B 2.15646
CXCL2 chemokine (C-X-C motif) ligand 2 2.15593
HDGFL3 HDGF like 3 2.14953
TEX2 testis expressed 2 2.12052
COPS5 COP9 signalosome subunit 5 2.11545
SLC67A1 solute carrier family 67 member 1 2.11516
MINDY1 MINDY lysine 48 deubiquitinase 1 2.11175
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.09085
LY6E lymphocyte antigen 6 complex, locus E 2.07217
KDM5A lysine (K)-specific demethylase 5A 2.06683
CCNF cyclin F 2.05663
GCLM glutamate-cysteine ligase, modifier subunit 2.03672
MIDEAS mitotic deacetylase associated SANT domain protein 2.02194
SCPEP1 serine carboxypeptidase 1 2.01416
GSR glutathione reductase 2.00805

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -8.12195
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -7.05625
TARBP1 TAR (HIV-1) RNA binding protein 1 -6.35584
LDHD lactate dehydrogenase D -6.34652
PSRC1 proline/serine-rich coiled-coil 1 -6.32753
MRPS2 mitochondrial ribosomal protein S2 -6.07708
PEG10 paternally expressed 10 -5.91074
FGFR4 fibroblast growth factor receptor 4 -5.71598
AURKB aurora kinase B -5.48029
ZNF586 zinc finger protein 586 -5.45539
OXA1L oxidase (cytochrome c) assembly 1-like -5.44341
CDK1 cyclin-dependent kinase 1 -5.41435
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.16055
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.98465
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.98155
NUP85 nucleoporin 85kDa -4.79301
UBE2C ubiquitin-conjugating enzyme E2C -4.7118
CCNB1 cyclin B1 -4.68185
STMN1 stathmin 1 -4.66392
CCNB2 cyclin B2 -4.51725
NT5DC2 5'-nucleotidase domain containing 2 -4.3742
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -4.21925
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.91831
PCNA proliferating cell nuclear antigen -3.86703
MELK maternal embryonic leucine zipper kinase -3.8201
HAT1 histone acetyltransferase 1 -3.69812
TOP2A topoisomerase (DNA) II alpha 170kDa -3.67546
DCK deoxycytidine kinase -3.54919
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.48765
ZMIZ1 zinc finger, MIZ-type containing 1 -3.47875
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.44058
MYL9 myosin, light chain 9, regulatory -3.40771
TRIB3 tribbles pseudokinase 3 -3.3741
DNM1L dynamin 1-like -3.33605
CCNA2 cyclin A2 -3.30262
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.23068
CHEK1 checkpoint kinase 1 -3.21419
TLR4 toll-like receptor 4 -3.19729
SNX11 sorting nexin 11 -3.17376
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.17276
POLR1A polymerase (RNA) I polypeptide A, 194kDa -3.16275
HMGA2 high mobility group AT-hook 2 -3.11769
TCTN1 tectonic family member 1 -3.06472
GOLT1B golgi transport 1B -3.05296
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.94721
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.946
TMEM106C transmembrane protein 106C -2.93675
PECR peroxisomal trans-2-enoyl-CoA reductase -2.90089
USP6NL USP6 N-terminal like -2.88372
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -2.87849
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.85176
KIF14 kinesin family member 14 -2.84756
RACGAP1 Rac GTPase activating protein 1 -2.84737
H2AX H2A.X variant histone -2.7786
PRPF4 pre-mRNA processing factor 4 -2.68603
NDC1 NDC1 transmembrane nucleoporin -2.66217
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.58108
KL klotho -2.56719
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.54392
GTF2A2 general transcription factor IIA, 2, 12kDa -2.51257
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.48266
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.48207
ECH1 enoyl CoA hydratase 1, peroxisomal -2.47067
HYDIN HYDIN, axonemal central pair apparatus protein -2.42317
KLK5 kallikrein-related peptidase 5 -2.42295
ISOC1 isochorismatase domain containing 1 -2.41255
MEFV Mediterranean fever -2.40593
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -2.40407
EDN1 endothelin 1 -2.40199
NCAPD2 non-SMC condensin I complex, subunit D2 -2.39795
RFC3 replication factor C (activator 1) 3, 38kDa -2.39713
ZWINT ZW10 interacting kinetochore protein -2.36453
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 -2.36292
DBR1 debranching RNA lariats 1 -2.36262
LY75-CD302 LY75-CD302 readthrough -2.34323
RPAP3 RNA polymerase II associated protein 3 -2.34051
RPS4Y1 ribosomal protein S4, Y-linked 1 -2.32765
ZNF528 zinc finger protein 528 -2.32544
FAIM Fas apoptotic inhibitory molecule -2.32225
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.31764
PLK1 polo-like kinase 1 -2.29948
ZNF253 zinc finger protein 253 -2.28201
HOXB9 homeobox B9 -2.27708
POF1B premature ovarian failure, 1B -2.27642
NUDCD3 NudC domain containing 3 -2.26265
VIL1 villin 1 -2.26058
FN3K fructosamine 3 kinase -2.24986
CROT carnitine O-octanoyltransferase -2.24685
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.24154
ENOPH1 enolase-phosphatase 1 -2.22951
SUMO4 small ubiquitin-like modifier 4 -2.21703
KIF11 kinesin family member 11 -2.20886
GPR88 G protein-coupled receptor 88 -2.2082
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.20795
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.20728
NIPSNAP1 nipsnap homolog 1 (C. elegans) -2.19312
TMEM97 transmembrane protein 97 -2.1822
MYO10 myosin X -2.17056
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -2.15935
KLK6 kallikrein-related peptidase 6 -2.14121
SOAT2 sterol O-acyltransferase 2 -2.13938
ZNF506 zinc finger protein 506 -2.13817
POLD2 polymerase (DNA directed), delta 2, accessory subunit -2.13717
ARHGAP8 Rho GTPase activating protein 8 -2.11898
ICAM1 intercellular adhesion molecule 1 -2.11248
NPC1 Niemann-Pick disease, type C1 -2.11095
GLOD4 glyoxalase domain containing 4 -2.09175
PPP1R16B protein phosphatase 1, regulatory subunit 16B -2.0895
RNASE6 ribonuclease, RNase A family, k6 -2.07424
CCL17 chemokine (C-C motif) ligand 17 -2.07404
TSPAN12 tetraspanin 12 -2.0694
SNRPA small nuclear ribonucleoprotein polypeptide A -2.0592
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.05067
BARX2 BARX homeobox 2 -2.04585
AIG1 androgen-induced 1 -2.04193
BIRC5 baculoviral IAP repeat containing 5 -2.03587
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.02723
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.02403
NLRX1 NLR family member X1 -2.01439
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial -2.00116