CRCGN010_HEPG2_24H:O11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenylazo-2-naphthol 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

146 genes differentially expressed following the CRCGN010_HEPG2_24H:O11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 9.70672
HMOX1 heme oxygenase 1 8.49481
ABHD4 abhydrolase domain containing 4 8.19349
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 7.70703
AMDHD2 amidohydrolase domain containing 2 6.40273
RAP1GAP RAP1 GTPase activating protein 6.20088
UGDH UDP-glucose 6-dehydrogenase 6.13673
SQSTM1 sequestosome 1 5.56202
VAT1 vesicle amine transport 1 5.3407
ZFP36 ZFP36 ring finger protein 5.14206
KEAP1 kelch-like ECH-associated protein 1 5.12708
MVP major vault protein 5.02241
CCNF cyclin F 4.80083
SQOR sulfide quinone oxidoreductase 4.14257
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.13423
SOCS2 suppressor of cytokine signaling 2 3.9983
ADRB2 adrenoceptor beta 2, surface 3.82018
CBR1 carbonyl reductase 1 3.74853
MEF2C myocyte enhancer factor 2C 3.57952
HSPA1A heat shock 70kDa protein 1A 3.53567
ALAS1 5'-aminolevulinate synthase 1 3.52238
GPATCH8 G patch domain containing 8 3.46384
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.4152
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.40706
ANO10 anoctamin 10 3.38076
BLMH bleomycin hydrolase 3.24536
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.17537
MYLK myosin light chain kinase 3.16575
SFTPB surfactant protein B 3.15
E2F2 E2F transcription factor 2 3.11114
DIPK1A divergent protein kinase domain 1A 3.08277
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.07243
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.03664
FOSL1 FOS-like antigen 1 2.96122
ATP11B ATPase, class VI, type 11B 2.90643
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.81224
HLA-DMA major histocompatibility complex, class II, DM alpha 2.81023
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.79772
MINDY1 MINDY lysine 48 deubiquitinase 1 2.79102
EPN2 epsin 2 2.78094
PRR15L proline rich 15-like 2.75772
OSGIN1 oxidative stress induced growth inhibitor 1 2.74496
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 2.7073
PER3 period circadian clock 3 2.70042
ATG3 autophagy related 3 2.59181
STAP2 signal transducing adaptor family member 2 2.55455
SLC25A46 solute carrier family 25, member 46 2.48407
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 2.47458
GCLM glutamate-cysteine ligase, modifier subunit 2.47139
SLC75A1 solute carrier family 75 member 1 2.42713
CRYZ crystallin, zeta (quinone reductase) 2.39415
TALDO1 transaldolase 1 2.3935
SMIM40 small integral membrane protein 40 2.38655
PEX11A peroxisomal biogenesis factor 11 alpha 2.37497
STIMATE STIM activating enhancer 2.36175
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 2.3535
NANOS3 nanos homolog 3 (Drosophila) 2.34896
ABHD6 abhydrolase domain containing 6 2.34352
CCL2 chemokine (C-C motif) ligand 2 2.30525
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 2.30026
CDC25B cell division cycle 25B 2.29687
RAB23 RAB23, member RAS oncogene family 2.29438
LPGAT1 lysophosphatidylglycerol acyltransferase 1 2.26573
LCN2 lipocalin 2 2.23938
PRKCD protein kinase C, delta 2.23078
KLHL21 kelch-like family member 21 2.22606
TACC2 transforming, acidic coiled-coil containing protein 2 2.20825
SPDEF SAM pointed domain containing ETS transcription factor 2.20668
CYTH1 cytohesin 1 2.18707
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.14471
BAAT bile acid CoA:amino acid N-acyltransferase 2.10636
GSR glutathione reductase 2.09823
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 2.0942
GSTA4 glutathione S-transferase alpha 4 2.06378
LOC122526780 uncharacterized LOC122526780 2.05857
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.04716
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.03777
ATXN1 ataxin 1 2.03738
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 2.02206

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.19012
ZNF586 zinc finger protein 586 -5.69732
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -4.91321
AURKB aurora kinase B -4.55089
RFC2 replication factor C (activator 1) 2, 40kDa -4.39261
ADI1 acireductone dioxygenase 1 -4.31049
PSRC1 proline/serine-rich coiled-coil 1 -4.2553
MELK maternal embryonic leucine zipper kinase -4.06415
CDC20 cell division cycle 20 -4.00457
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.90264
CDK1 cyclin-dependent kinase 1 -3.87814
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.78146
HMGA2 high mobility group AT-hook 2 -3.69504
ISOC1 isochorismatase domain containing 1 -3.68945
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.6831
TUBB6 tubulin, beta 6 class V -3.6829
ZMIZ1 zinc finger, MIZ-type containing 1 -3.35028
PRPF4 pre-mRNA processing factor 4 -3.33612
TOP2A topoisomerase (DNA) II alpha 170kDa -3.29785
SLC35F2 solute carrier family 35, member F2 -3.26717
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -3.26586
PTPRK protein tyrosine phosphatase, receptor type, K -3.23807
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -3.13374
DNM1L dynamin 1-like -3.06196
LDHD lactate dehydrogenase D -3.05567
THAP11 THAP domain containing 11 -3.05424
UBE2C ubiquitin-conjugating enzyme E2C -2.94896
PDZD2 PDZ domain containing 2 -2.9425
HAT1 histone acetyltransferase 1 -2.92148
PPOX protoporphyrinogen oxidase -2.88927
PBK PDZ binding kinase -2.82061
KIF14 kinesin family member 14 -2.77223
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.76902
CCNA2 cyclin A2 -2.76137
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.73354
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.68408
HYOU1 hypoxia up-regulated 1 -2.66929
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.65046
TCTN1 tectonic family member 1 -2.627
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.62648
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.59048
PECR peroxisomal trans-2-enoyl-CoA reductase -2.5734
BIRC5 baculoviral IAP repeat containing 5 -2.54367
SOAT2 sterol O-acyltransferase 2 -2.51321
PLK1 polo-like kinase 1 -2.48572
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.4284
NRIP1 nuclear receptor interacting protein 1 -2.40015
FGFR4 fibroblast growth factor receptor 4 -2.38082
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.369
NCAPD2 non-SMC condensin I complex, subunit D2 -2.35786
KIF11 kinesin family member 11 -2.34219
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.34016
CHMP4B charged multivesicular body protein 4B -2.28044
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.25878
OXCT1 3-oxoacid CoA transferase 1 -2.23748
FBXO5 F-box protein 5 -2.21533
NUP85 nucleoporin 85kDa -2.16194
RAD51AP1 RAD51 associated protein 1 -2.10036
ASF1B anti-silencing function 1B histone chaperone -2.07403
STIL SCL/TAL1 interrupting locus -2.0694
E2F8 E2F transcription factor 8 -2.06339
DNMT1 DNA (cytosine-5-)-methyltransferase 1 -2.05517
NDC80 NDC80 kinetochore complex component -2.04825
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.04666
C5 complement component 5 -2.04376
TGIF2 TGFB-induced factor homeobox 2 -2.03722
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.0332