CRCGN010_HEPG2_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenylazo-2-naphthol 1.25 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN010_HEPG2_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 10.0
TXNRD1 thioredoxin reductase 1 9.99557
MAP7 microtubule-associated protein 7 7.7803
HMOX1 heme oxygenase 1 7.71691
UGDH UDP-glucose 6-dehydrogenase 6.48952
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 6.48772
MYLK myosin light chain kinase 6.46057
GPER1 G protein-coupled estrogen receptor 1 6.1136
ABHD4 abhydrolase domain containing 4 5.62813
RAP1GAP RAP1 GTPase activating protein 5.48152
DYNLT3 dynein, light chain, Tctex-type 3 5.12922
SQSTM1 sequestosome 1 4.87687
ABHD6 abhydrolase domain containing 6 4.77585
VAT1 vesicle amine transport 1 4.63518
ZFP36 ZFP36 ring finger protein 4.49911
SQOR sulfide quinone oxidoreductase 4.23612
MVP major vault protein 4.16682
KEAP1 kelch-like ECH-associated protein 1 4.14335
PPARG peroxisome proliferator-activated receptor gamma 3.93145
CYCS cytochrome c, somatic 3.64021
RPP38 ribonuclease P/MRP 38kDa subunit 3.5453
CEMIP2 cell migration inducing hyaluronidase 2 3.50542
SORBS3 sorbin and SH3 domain containing 3 3.45987
STIMATE STIM activating enhancer 3.43148
DIPK1A divergent protein kinase domain 1A 3.36785
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.30118
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.28416
CD40 CD40 molecule, TNF receptor superfamily member 5 3.27656
HLA-DMA major histocompatibility complex, class II, DM alpha 3.07939
RAB21 RAB21, member RAS oncogene family 3.04053
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.94972
AMDHD2 amidohydrolase domain containing 2 2.83681
NOTCH1 notch 1 2.82114
ALAS1 5'-aminolevulinate synthase 1 2.78584
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.76184
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.74471
NANOS3 nanos homolog 3 (Drosophila) 2.7212
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.71629
FOSL1 FOS-like antigen 1 2.62699
AKR1C3 aldo-keto reductase family 1, member C3 2.60381
ZDHHC11B zinc finger, DHHC-type containing 11B 2.59796
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.59377
E2F2 E2F transcription factor 2 2.57266
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.53363
CEP131 centrosomal protein 131kDa 2.51579
HAUS2 HAUS augmin-like complex, subunit 2 2.48206
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) 2.47545
HLA-DRA major histocompatibility complex, class II, DR alpha 2.45285
HBA1 hemoglobin, alpha 1 2.43009
TIAM1 T-cell lymphoma invasion and metastasis 1 2.40565
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.4002
CHMP6 charged multivesicular body protein 6 2.3927
CDC25B cell division cycle 25B 2.38194
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.37379
MMRN2 multimerin 2 2.3448
HSPA1A heat shock 70kDa protein 1A 2.30005
LPAR2 lysophosphatidic acid receptor 2 2.28712
SSTR1 somatostatin receptor 1 2.28272
GCLC glutamate-cysteine ligase, catalytic subunit 2.27245
CARMIL1 capping protein regulator and myosin 1 linker 1 2.26944
FBLN2 fibulin 2 2.26166
PRR11 proline rich 11 2.23175
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.22464
WDR91 WD repeat domain 91 2.22405
GPX2 glutathione peroxidase 2 2.20662
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.2011
MYH7B myosin, heavy chain 7B, cardiac muscle, beta 2.19165
DHRS7 dehydrogenase/reductase (SDR family) member 7 2.18243
GATA2 GATA binding protein 2 2.17639
TALDO1 transaldolase 1 2.16584
GDAP1 ganglioside induced differentiation associated protein 1 2.16096
INTS3 integrator complex subunit 3 2.13969
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.13278
GCLM glutamate-cysteine ligase, modifier subunit 2.11571
HBB hemoglobin, beta 2.11497
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.10557
HS1BP3 HCLS1 binding protein 3 2.08636
ZNF611 zinc finger protein 611 2.07759
ADIRF adipogenesis regulatory factor 2.07362
WASHC5 WASH complex subunit 5 2.06754
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.06639
RNASE12 ribonuclease, RNase A family, 12 (non-active) 2.06575
RBKS ribokinase 2.04879
CEP57 centrosomal protein 57kDa 2.02629
BAG3 BCL2-associated athanogene 3 2.01694
ATG3 autophagy related 3 2.00814

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.49226
PSRC1 proline/serine-rich coiled-coil 1 -6.4778
MRPS2 mitochondrial ribosomal protein S2 -5.99111
TLCD3A TLC domain containing 3A -5.52817
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -5.18729
SLC35F2 solute carrier family 35, member F2 -5.15157
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.10578
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.71641
GNAS GNAS complex locus -4.12087
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -3.99662
CD320 CD320 molecule -3.93618
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.83975
TRIB3 tribbles pseudokinase 3 -3.81619
FGFR4 fibroblast growth factor receptor 4 -3.74645
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -3.69491
GOLT1B golgi transport 1B -3.55977
TCTN1 tectonic family member 1 -3.44677
STMN1 stathmin 1 -3.39931
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.33578
CDC20 cell division cycle 20 -3.28953
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.25227
USP6NL USP6 N-terminal like -3.21297
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.20934
LAP3 leucine aminopeptidase 3 -3.18789
ADI1 acireductone dioxygenase 1 -3.06464
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.06311
ISOC1 isochorismatase domain containing 1 -3.01534
HAT1 histone acetyltransferase 1 -2.93777
KIF14 kinesin family member 14 -2.84826
NCAPD2 non-SMC condensin I complex, subunit D2 -2.65755
WASHC4 WASH complex subunit 4 -2.6559
COPS7A COP9 signalosome subunit 7A -2.62897
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -2.5168
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.48277
PDZD2 PDZ domain containing 2 -2.44953
MLF2 myeloid leukemia factor 2 -2.44812
POLR1A polymerase (RNA) I polypeptide A, 194kDa -2.44659
PECR peroxisomal trans-2-enoyl-CoA reductase -2.43819
AURKB aurora kinase B -2.43209
PCNA proliferating cell nuclear antigen -2.43185
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.38706
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.33275
SESN1 sestrin 1 -2.31942
RNF167 ring finger protein 167 -2.29444
YME1L1 YME1-like 1 ATPase -2.28086
CCNA2 cyclin A2 -2.26241
TRAPPC6A trafficking protein particle complex 6A -2.20769
BBLN bublin coiled coil protein -2.20489
CDK1 cyclin-dependent kinase 1 -2.20346
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.19736
UBE2C ubiquitin-conjugating enzyme E2C -2.19165
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -2.16248
MARCKSL1 MARCKS-like 1 -2.11129
PLK1 polo-like kinase 1 -2.09294
SH3GLB2 SH3-domain GRB2-like endophilin B2 -2.09175
VAV3 vav 3 guanine nucleotide exchange factor -2.06087
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.05428
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -2.05279
DBF4 DBF4 zinc finger -2.05105
ALG8 ALG8, alpha-1,3-glucosyltransferase -2.04909
CCL20 chemokine (C-C motif) ligand 20 -2.03908
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00621
MAPK13 mitogen-activated protein kinase 13 -2.00141