CRCGN010_HEPG2_24H:O18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fd & c yellow no. 6 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN010_HEPG2_24H:O18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NOTCH1 notch 1 5.3813
CXCL2 chemokine (C-X-C motif) ligand 2 4.75193
CBR3 carbonyl reductase 3 4.72535
GSTZ1 glutathione S-transferase zeta 1 4.59919
RPP38 ribonuclease P/MRP 38kDa subunit 4.54489
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.47554
PMM2 phosphomannomutase 2 4.20704
PRKCQ protein kinase C, theta 4.08925
CIAO3 cytosolic iron-sulfur assembly component 3 3.51927
CYCS cytochrome c, somatic 3.42083
HLA-DMA major histocompatibility complex, class II, DM alpha 3.1535
CHN1 chimerin 1 3.09919
ZNF589 zinc finger protein 589 2.69818
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.64985
ZFP36 ZFP36 ring finger protein 2.2662
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.24614
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.24403
MTCH2 mitochondrial carrier 2 2.15565
RHOG ras homolog family member G 2.08733

decreased expression

Symbol Name Standardized Value
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -10.0
TLR4 toll-like receptor 4 -8.4633
TLCD3A TLC domain containing 3A -7.21439
PCNA proliferating cell nuclear antigen -5.32307
COG2 component of oligomeric golgi complex 2 -5.04483
ZMIZ1 zinc finger, MIZ-type containing 1 -4.6627
DUSP6 dual specificity phosphatase 6 -4.13604
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.85339
CCNB2 cyclin B2 -3.73979
SCCPDH saccharopine dehydrogenase (putative) -3.44386
WDR7 WD repeat domain 7 -3.29795
CHMP4B charged multivesicular body protein 4B -3.29241
GNAS GNAS complex locus -3.10039
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.54747
VDAC1 voltage-dependent anion channel 1 -2.41874
DCK deoxycytidine kinase -2.39329
FBXO7 F-box protein 7 -2.38405
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.0688
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.06347
HSPA8 heat shock 70kDa protein 8 -2.02394
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.01555
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -2.01051