CRCGN010_HEPG2_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiram 19.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

104 genes differentially expressed following the CRCGN010_HEPG2_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KIFBP kinesin family binding protein 6.36806
CXCL2 chemokine (C-X-C motif) ligand 2 5.83675
MVP major vault protein 5.26653
INPP1 inositol polyphosphate-1-phosphatase 4.8219
TUBB6 tubulin, beta 6 class V 4.14
SFTPB surfactant protein B 3.92852
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 3.87661
NOTCH1 notch 1 3.63324
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.46031
SQOR sulfide quinone oxidoreductase 3.39514
EPN2 epsin 2 3.38666
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.33408
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.19134
FHL2 four and a half LIM domains 2 3.02015
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.96313
TOMM34 translocase of outer mitochondrial membrane 34 2.95893
CCL2 chemokine (C-C motif) ligand 2 2.86138
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.79683
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.76309
PRR15L proline rich 15-like 2.6773
SKIC2 SKI2 subunit of superkiller complex 2.64607
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.63021
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.5482
CDPF1 cysteine-rich, DPF motif domain containing 1 2.52411
ALAS1 5'-aminolevulinate synthase 1 2.50589
PRKCH protein kinase C, eta 2.43861
IER3 immediate early response 3 2.42209
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 2.37666
FPGS folylpolyglutamate synthase 2.34405
TMEM50A transmembrane protein 50A 2.31806
ICAM1 intercellular adhesion molecule 1 2.27078
C2CD2 C2 calcium-dependent domain containing 2 2.25702
SOCS2 suppressor of cytokine signaling 2 2.25564
TERF2IP telomeric repeat binding factor 2, interacting protein 2.20887
TRIB1 tribbles pseudokinase 1 2.20326
EGR1 early growth response 1 2.19587
FOSL1 FOS-like antigen 1 2.18305
GLRX glutaredoxin (thioltransferase) 2.15696
DUSP6 dual specificity phosphatase 6 2.14966
TIMP2 TIMP metallopeptidase inhibitor 2 2.13163
LCN2 lipocalin 2 2.12868
ACOT9 acyl-CoA thioesterase 9 2.09883
EDN1 endothelin 1 2.07313
NVL nuclear VCP-like 2.06402
CYCS cytochrome c, somatic 2.06273
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.06242
VGLL4 vestigial-like family member 4 2.0147
CD40 CD40 molecule, TNF receptor superfamily member 5 2.00817

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -8.06969
LDHD lactate dehydrogenase D -6.76827
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -6.7191
TCTN1 tectonic family member 1 -6.31296
KDM3A lysine (K)-specific demethylase 3A -4.55392
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -4.25556
CDC25B cell division cycle 25B -4.05655
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -3.94397
ALDOC aldolase C, fructose-bisphosphate -3.82866
ANKRD10 ankyrin repeat domain 10 -3.70636
FBXL12 F-box and leucine-rich repeat protein 12 -3.70187
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.64212
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -3.5666
PGM1 phosphoglucomutase 1 -3.51542
DDIT4 DNA-damage-inducible transcript 4 -3.47592
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.34375
NRIP1 nuclear receptor interacting protein 1 -3.2259
DERA deoxyribose-phosphate aldolase (putative) -3.22058
SOAT2 sterol O-acyltransferase 2 -3.15485
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -3.1275
RPS4Y1 ribosomal protein S4, Y-linked 1 -3.06577
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.04851
ISOC1 isochorismatase domain containing 1 -2.96711
PYCR1 pyrroline-5-carboxylate reductase 1 -2.88274
CCNB2 cyclin B2 -2.7436
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.60944
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.58081
B4GAT1 beta-1,4-glucuronyltransferase 1 -2.52779
GOLT1B golgi transport 1B -2.4887
GATA4 GATA binding protein 4 -2.42176
ECH1 enoyl CoA hydratase 1, peroxisomal -2.38632
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -2.33085
LYPLA1 lysophospholipase I -2.33076
FASTKD5 FAST kinase domains 5 -2.31808
FGFR4 fibroblast growth factor receptor 4 -2.30644
MELK maternal embryonic leucine zipper kinase -2.22306
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.20522
DENND2D DENN/MADD domain containing 2D -2.20519
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.20359
PHGDH phosphoglycerate dehydrogenase -2.20121
CGREF1 cell growth regulator with EF-hand domain 1 -2.19034
PANK3 pantothenate kinase 3 -2.18245
CCNA2 cyclin A2 -2.16645
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -2.15308
CHIC2 cysteine-rich hydrophobic domain 2 -2.1435
STMN1 stathmin 1 -2.1376
CCKBR cholecystokinin B receptor -2.13138
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.11967
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -2.11636
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.10608
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.10071
FBXO31 F-box protein 31 -2.07977
UBE3C ubiquitin protein ligase E3C -2.06226
PSRC1 proline/serine-rich coiled-coil 1 -2.03743
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.02532
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.01093