CRCGN010_HEPG2_24H:O21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiram 9.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

68 genes differentially expressed following the CRCGN010_HEPG2_24H:O21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 7.23978
NOTCH1 notch 1 3.98163
MEF2C myocyte enhancer factor 2C 3.74407
UBQLN2 ubiquilin 2 3.71707
CSK c-src tyrosine kinase 3.63468
PNKP polynucleotide kinase 3'-phosphatase 3.21769
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.07973
CDPF1 cysteine-rich, DPF motif domain containing 1 3.06896
LPAR2 lysophosphatidic acid receptor 2 3.02739
CCNF cyclin F 2.99098
CIAO3 cytosolic iron-sulfur assembly component 3 2.94717
NOSIP nitric oxide synthase interacting protein 2.86571
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 2.85373
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.82882
CCL2 chemokine (C-C motif) ligand 2 2.80275
CNPY3 canopy FGF signaling regulator 3 2.75648
EVL Enah/Vasp-like 2.55642
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.52815
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.51965
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.41851
HLA-DRA major histocompatibility complex, class II, DR alpha 2.41618
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.31301
KIFBP kinesin family binding protein 2.29197
CGRRF1 cell growth regulator with ring finger domain 1 2.27445
TRIM22 tripartite motif containing 22 2.2543
SATB1 SATB homeobox 1 2.20555
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.20294
TUBB6 tubulin, beta 6 class V 2.16058
DIPK1A divergent protein kinase domain 1A 2.126
HLA-DMA major histocompatibility complex, class II, DM alpha 2.07801

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -6.79538
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -6.16958
LDHD lactate dehydrogenase D -6.10526
NCK1 NCK adaptor protein 1 -4.82461
TCTN1 tectonic family member 1 -4.53483
GNAS GNAS complex locus -4.39318
ADI1 acireductone dioxygenase 1 -3.83262
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.77706
NT5DC2 5'-nucleotidase domain containing 2 -3.45415
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.41529
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.30387
ZNF586 zinc finger protein 586 -3.27861
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -3.18915
FGFR4 fibroblast growth factor receptor 4 -3.16851
PRPF4 pre-mRNA processing factor 4 -3.16368
ZDHHC6 zinc finger, DHHC-type containing 6 -3.06182
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.99287
SOAT2 sterol O-acyltransferase 2 -2.98477
THAP11 THAP domain containing 11 -2.93245
PEG10 paternally expressed 10 -2.84852
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.7202
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.64149
STX4 syntaxin 4 -2.58793
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.55105
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.46803
NRIP1 nuclear receptor interacting protein 1 -2.39345
MTFR1 mitochondrial fission regulator 1 -2.3693
AVPI1 arginine vasopressin-induced 1 -2.31046
ALDOC aldolase C, fructose-bisphosphate -2.30422
PDZD2 PDZ domain containing 2 -2.28258
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.27248
PGM1 phosphoglucomutase 1 -2.26981
USP6NL USP6 N-terminal like -2.26008
PECR peroxisomal trans-2-enoyl-CoA reductase -2.25878
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) -2.12292
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -2.07181
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.06406
TMPRSS11E transmembrane protease, serine 11E -2.01876