CRCGN010_HEPG2_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description thiram 2.47 um perturbation at 24 h in HEPG2 (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

72 genes differentially expressed following the CRCGN010_HEPG2_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 10.0
CIAO3 cytosolic iron-sulfur assembly component 3 6.72504
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.19861
VGLL4 vestigial-like family member 4 4.13893
RPP38 ribonuclease P/MRP 38kDa subunit 3.87294
CSK c-src tyrosine kinase 3.61347
E2F2 E2F transcription factor 2 3.60107
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.60069
GSTZ1 glutathione S-transferase zeta 1 3.27521
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.27175
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.17199
HLA-DMA major histocompatibility complex, class II, DM alpha 3.15195
PNKP polynucleotide kinase 3'-phosphatase 3.06594
ATP11B ATPase, class VI, type 11B 3.0552
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.97286
PPARG peroxisome proliferator-activated receptor gamma 2.94053
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.88187
LCN2 lipocalin 2 2.86588
MYLK myosin light chain kinase 2.82018
EPN2 epsin 2 2.77375
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.72338
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.61942
DUOX2 dual oxidase 2 2.56824
PEX11A peroxisomal biogenesis factor 11 alpha 2.56303
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble 2.52755
SNAP25 synaptosomal-associated protein, 25kDa 2.4995
HSPA1A heat shock 70kDa protein 1A 2.48311
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.39891
NMU neuromedin U 2.19765
POLL polymerase (DNA directed), lambda 2.17435
PACS1 phosphofurin acidic cluster sorting protein 1 2.15936
TIAM1 T-cell lymphoma invasion and metastasis 1 2.14881
NOSIP nitric oxide synthase interacting protein 2.14522
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.12607
OR7A5 olfactory receptor, family 7, subfamily A, member 5 2.12359
CXCL3 chemokine (C-X-C motif) ligand 3 2.07588
CGRRF1 cell growth regulator with ring finger domain 1 2.07157
CDH18 cadherin 18, type 2 2.06672
CLCN5 chloride channel, voltage-sensitive 5 2.0636
MRPL39 mitochondrial ribosomal protein L39 2.06217
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.05784
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.03167
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 2.01525
NOL8 nucleolar protein 8 2.0073
RTCA RNA 3'-terminal phosphate cyclase 2.00569

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -9.94968
ZNF586 zinc finger protein 586 -8.82511
MAPK13 mitogen-activated protein kinase 13 -4.6332
NT5DC2 5'-nucleotidase domain containing 2 -4.07994
TRAP1 TNF receptor-associated protein 1 -3.89478
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.89431
CASP7 caspase 7, apoptosis-related cysteine peptidase -3.73848
UGDH UDP-glucose 6-dehydrogenase -3.53837
CCNB1 cyclin B1 -3.38282
DSG2 desmoglein 2 -3.37412
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -3.3412
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.20401
RNF167 ring finger protein 167 -3.07276
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.96585
C2CD5 C2 calcium-dependent domain containing 5 -2.84393
RFC2 replication factor C (activator 1) 2, 40kDa -2.8309
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.78623
TCTN1 tectonic family member 1 -2.63895
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.51763
SPAG4 sperm associated antigen 4 -2.50934
FGFR4 fibroblast growth factor receptor 4 -2.22776
TOR1A torsin family 1, member A (torsin A) -2.21056
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.15658
TMEM97 transmembrane protein 97 -2.13333
METTL8 methyltransferase like 8 -2.05382
TOX3 TOX high mobility group box family member 3 -2.0419
VDAC1 voltage-dependent anion channel 1 -2.03029