| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | oxymetholone 40.4 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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114 genes differentially expressed following the CRCGN010_HEPG2_24H:P01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 9.87296 |
| ABHD4 | abhydrolase domain containing 4 | 9.42711 |
| KEAP1 | kelch-like ECH-associated protein 1 | 7.16373 |
| UGDH | UDP-glucose 6-dehydrogenase | 6.48279 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 6.4082 |
| LCN2 | lipocalin 2 | 6.08413 |
| HMOX1 | heme oxygenase 1 | 6.06629 |
| SQSTM1 | sequestosome 1 | 5.35567 |
| MAP7 | microtubule-associated protein 7 | 5.13152 |
| HSPA1A | heat shock 70kDa protein 1A | 5.11414 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 4.48562 |
| CTSL | cathepsin L | 4.38617 |
| TEX10 | testis expressed 10 | 4.28097 |
| CDC45 | cell division cycle 45 | 4.18193 |
| SLC75A1 | solute carrier family 75 member 1 | 3.78998 |
| CSK | c-src tyrosine kinase | 3.71687 |
| FOSL1 | FOS-like antigen 1 | 3.59416 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 3.57274 |
| RRAGA | Ras-related GTP binding A | 3.56751 |
| CBR1 | carbonyl reductase 1 | 3.49545 |
| SFTPB | surfactant protein B | 3.44766 |
| UBQLN2 | ubiquilin 2 | 3.39737 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 3.36804 |
| RAP1GAP | RAP1 GTPase activating protein | 3.34435 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 3.29185 |
| GPC1 | glypican 1 | 3.24658 |
| CHMP6 | charged multivesicular body protein 6 | 3.21818 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 3.18981 |
| INPP1 | inositol polyphosphate-1-phosphatase | 3.07056 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 2.74351 |
| INTS3 | integrator complex subunit 3 | 2.73211 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.60341 |
| CRTAP | cartilage associated protein | 2.56543 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.55855 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 2.53956 |
| CCND3 | cyclin D3 | 2.53944 |
| TMEM50A | transmembrane protein 50A | 2.45914 |
| FHL2 | four and a half LIM domains 2 | 2.44899 |
| ZW10 | zw10 kinetochore protein | 2.44775 |
| USP6NL | USP6 N-terminal like | 2.40508 |
| HSPA8 | heat shock 70kDa protein 8 | 2.38657 |
| TMEM109 | transmembrane protein 109 | 2.31738 |
| EVL | Enah/Vasp-like | 2.23863 |
| BLMH | bleomycin hydrolase | 2.23332 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 2.18915 |
| KLHL21 | kelch-like family member 21 | 2.16274 |
| SACM1L | SAC1 suppressor of actin mutations 1-like (yeast) | 2.16214 |
| MCOLN1 | mucolipin 1 | 2.1382 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 2.11265 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 2.1005 |
| MVP | major vault protein | 2.08977 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.08229 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 2.06544 |
| TALDO1 | transaldolase 1 | 2.06028 |
| LOC124907782 | dual specificity protein phosphatase 22 | 2.05431 |
| BAG3 | BCL2-associated athanogene 3 | 2.04871 |
| AKR1A1 | aldo-keto reductase family 1, member A1 (aldehyde reductase) | 2.03522 |
| TSPYL4 | TSPY-like 4 | 2.03025 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CCNB2 | cyclin B2 | -9.89933 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -7.16613 |
| TLCD3A | TLC domain containing 3A | -7.1616 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -6.352 |
| TLR4 | toll-like receptor 4 | -6.02713 |
| CDC20 | cell division cycle 20 | -4.5426 |
| CRELD2 | cysteine-rich with EGF-like domains 2 | -4.53769 |
| FAIM | Fas apoptotic inhibitory molecule | -4.52107 |
| CCNB1 | cyclin B1 | -4.23459 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -3.99944 |
| MYL9 | myosin, light chain 9, regulatory | -3.80033 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.4778 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -3.46768 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -3.39208 |
| FGFR4 | fibroblast growth factor receptor 4 | -3.31285 |
| CD320 | CD320 molecule | -3.25827 |
| LDHD | lactate dehydrogenase D | -3.16428 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -3.13164 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.10873 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -3.06926 |
| PCNA | proliferating cell nuclear antigen | -2.98323 |
| EDN1 | endothelin 1 | -2.94689 |
| AURKB | aurora kinase B | -2.83325 |
| COG7 | component of oligomeric golgi complex 7 | -2.75622 |
| TRIB3 | tribbles pseudokinase 3 | -2.68861 |
| KIF14 | kinesin family member 14 | -2.63287 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -2.60795 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -2.59995 |
| HYOU1 | hypoxia up-regulated 1 | -2.5956 |
| GFRA1 | GDNF family receptor alpha 1 | -2.56143 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -2.53754 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.53662 |
| KLHDC2 | kelch domain containing 2 | -2.50216 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -2.43608 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -2.42134 |
| CCNA2 | cyclin A2 | -2.39696 |
| EIF5 | eukaryotic translation initiation factor 5 | -2.35884 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -2.3285 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.28752 |
| GMNN | geminin, DNA replication inhibitor | -2.23242 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -2.22028 |
| PGAM4 | phosphoglycerate mutase family member 4 | -2.2168 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | -2.21672 |
| PIMREG | PICALM interacting mitotic regulator | -2.19167 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -2.18382 |
| NMRK1 | nicotinamide riboside kinase 1 | -2.14436 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -2.12639 |
| OSTM1 | osteopetrosis associated transmembrane protein 1 | -2.09674 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -2.08766 |
| NIT1 | nitrilase 1 | -2.08156 |
| PYCR3 | pyrroline-5-carboxylate reductase 3 | -2.05681 |
| AUNIP | aurora kinase A and ninein interacting protein | -2.05339 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -2.02683 |
| MEOX1 | mesenchyme homeobox 1 | -2.02493 |
| CYP2R1 | cytochrome P450, family 2, subfamily R, polypeptide 1 | -2.02377 |
| PDE1B | phosphodiesterase 1B, calmodulin-dependent | -2.01767 |
