CRCGN010_HEPG2_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 20.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

245 genes differentially expressed following the CRCGN010_HEPG2_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 8.24935
ABHD4 abhydrolase domain containing 4 7.46689
RPP38 ribonuclease P/MRP 38kDa subunit 7.00734
STK10 serine/threonine kinase 10 6.76307
KEAP1 kelch-like ECH-associated protein 1 5.70596
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 5.19207
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 4.51712
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 4.42793
BZW2 basic leucine zipper and W2 domains 2 4.42643
MSRA methionine sulfoxide reductase A 4.41524
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.34993
MYC v-myc avian myelocytomatosis viral oncogene homolog 4.31515
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 4.21194
LOC122526780 uncharacterized LOC122526780 4.18446
WDR7 WD repeat domain 7 4.15626
CSK c-src tyrosine kinase 4.05045
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.03387
MCOLN1 mucolipin 1 3.94076
CBR1 carbonyl reductase 1 3.736
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.68229
UGDH UDP-glucose 6-dehydrogenase 3.6534
BPHL biphenyl hydrolase-like (serine hydrolase) 3.60669
UBE3C ubiquitin protein ligase E3C 3.54092
PLS1 plastin 1 3.50397
MEST mesoderm specific transcript 3.49452
CTSL cathepsin L 3.49294
TRAP1 TNF receptor-associated protein 1 3.4182
HMOX1 heme oxygenase 1 3.3455
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 3.34295
FOSL1 FOS-like antigen 1 3.30776
AMDHD2 amidohydrolase domain containing 2 3.2191
CCNA1 cyclin A1 3.21248
ALAS1 5'-aminolevulinate synthase 1 3.20683
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 3.1862
BAD BCL2-associated agonist of cell death 3.14028
PNKP polynucleotide kinase 3'-phosphatase 3.11188
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 3.04403
RHOA ras homolog family member A 3.03641
PPIC peptidylprolyl isomerase C (cyclophilin C) 3.01743
GCLC glutamate-cysteine ligase, catalytic subunit 2.98436
NNT nicotinamide nucleotide transhydrogenase 2.97868
LOC124907782 dual specificity protein phosphatase 22 2.97099
DUSP14 dual specificity phosphatase 14 2.94338
CD40 CD40 molecule, TNF receptor superfamily member 5 2.93733
NT5DC2 5'-nucleotidase domain containing 2 2.92651
GPATCH8 G patch domain containing 8 2.92074
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.91082
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.90278
CASC3 cancer susceptibility candidate 3 2.88063
TRAPPC3 trafficking protein particle complex 3 2.85668
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.84197
GSAP gamma-secretase activating protein 2.83637
PRKCD protein kinase C, delta 2.83588
CLCN3 chloride channel, voltage-sensitive 3 2.79279
HMG20B high mobility group 20B 2.78124
BIRC2 baculoviral IAP repeat containing 2 2.77698
BLCAP bladder cancer associated protein 2.77586
VGLL4 vestigial-like family member 4 2.76452
GCLM glutamate-cysteine ligase, modifier subunit 2.74745
ANKRD10 ankyrin repeat domain 10 2.73399
SQSTM1 sequestosome 1 2.73365
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.70501
GSTA4 glutathione S-transferase alpha 4 2.68199
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.66554
TEX10 testis expressed 10 2.61214
PPARG peroxisome proliferator-activated receptor gamma 2.58753
CASP2 caspase 2, apoptosis-related cysteine peptidase 2.56788
SFTPB surfactant protein B 2.56735
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.56498
COG2 component of oligomeric golgi complex 2 2.55594
SPAG7 sperm associated antigen 7 2.54322
GPC1 glypican 1 2.54177
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.54147
TMEM147 transmembrane protein 147 2.53385
TRIM16 tripartite motif containing 16 2.53149
PTDSS2 phosphatidylserine synthase 2 2.51579
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.51461
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.50143
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.49912
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.48462
STXBP1 syntaxin binding protein 1 2.46093
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.43321
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.39041
NISCH nischarin 2.36858
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.36834
RBM38 RNA binding motif protein 38 2.33417
DENND2B DENN domain containing 2B 2.32858
MORC3 MORC family CW-type zinc finger 3 2.31604
SCARB1 scavenger receptor class B, member 1 2.30242
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 2.29212
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 2.2897
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.28207
INPP1 inositol polyphosphate-1-phosphatase 2.27575
NLRP2B NLR family pyrin domain containing 2B 2.24321
NKX2-5 NK2 homeobox 5 2.24016
PLA2G15 phospholipase A2, group XV 2.23704
NUP205 nucleoporin 205kDa 2.23605
KAT5 K(lysine) acetyltransferase 5 2.2309
MAP3K4 mitogen-activated protein kinase kinase kinase 4 2.22588
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.22449
CHERP calcium homeostasis endoplasmic reticulum protein 2.21543
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 2.20857
ELAVL1 ELAV like RNA binding protein 1 2.20803
NUP133 nucleoporin 133kDa 2.20788
SLC75A1 solute carrier family 75 member 1 2.205
MLEC malectin 2.18944
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 2.18648
ARFIP2 ADP-ribosylation factor interacting protein 2 2.16318
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.15624
FXR2 fragile X mental retardation, autosomal homolog 2 2.15011
AP3D1 adaptor-related protein complex 3, delta 1 subunit 2.14545
TMEM131 transmembrane protein 131 2.13176
PPP1R15A protein phosphatase 1, regulatory subunit 15A 2.12989
SHB Src homology 2 domain containing adaptor protein B 2.11415
ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2.10793
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.10593
KLHL22 kelch-like family member 22 2.10345
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.10127
STXBP2 syntaxin binding protein 2 2.09734
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 2.09412
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 2.08758
ENAH enabled homolog (Drosophila) 2.06962
RALGDS ral guanine nucleotide dissociation stimulator 2.06936
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.06793
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.06716
KDM7A lysine (K)-specific demethylase 7A 2.06366
TMCC2 transmembrane and coiled-coil domain family 2 2.05852
TASOR2 transcription activation suppressor family member 2 2.04816
SLC12A9 solute carrier family 12, member 9 2.0412
CMTR1 cap methyltransferase 1 2.03837
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 2.03711
HLA-DMA major histocompatibility complex, class II, DM alpha 2.03226
CRTAM cytotoxic and regulatory T cell molecule 2.03074
EMP3 epithelial membrane protein 3 2.02901
TSPAN9 tetraspanin 9 2.02745
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.02483
USP6 ubiquitin specific peptidase 6 2.01833
IL36R interleukin 36 receptor 2.01633
NKG7 natural killer cell granule protein 7 2.01481
EPN2 epsin 2 2.01122
TNIP3 TNFAIP3 interacting protein 3 2.00899
TMEM80 transmembrane protein 80 2.00274

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -6.38392
ZNF586 zinc finger protein 586 -6.17363
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.47586
TCTN1 tectonic family member 1 -5.27237
TM9SF2 transmembrane 9 superfamily member 2 -5.12876
ZW10 zw10 kinetochore protein -5.09419
NGRN neugrin, neurite outgrowth associated -4.91874
VAT1 vesicle amine transport 1 -4.91603
RPN1 ribophorin I -4.91461
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.85355
EBNA1BP2 EBNA1 binding protein 2 -4.61718
OXA1L oxidase (cytochrome c) assembly 1-like -4.58138
MYL9 myosin, light chain 9, regulatory -4.48057
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -4.47983
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.17443
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -4.16643
CRYZ crystallin, zeta (quinone reductase) -4.1641
CDC20 cell division cycle 20 -4.1093
FBXL12 F-box and leucine-rich repeat protein 12 -4.08245
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -4.0371
PTPRK protein tyrosine phosphatase, receptor type, K -3.92048
HAT1 histone acetyltransferase 1 -3.89997
CCNB2 cyclin B2 -3.84327
THAP11 THAP domain containing 11 -3.76401
USP22 ubiquitin specific peptidase 22 -3.76322
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.76097
SCAND1 SCAN domain containing 1 -3.75883
HYOU1 hypoxia up-regulated 1 -3.63709
MTFR1 mitochondrial fission regulator 1 -3.52377
DDIT4 DNA-damage-inducible transcript 4 -3.50937
PRCP prolylcarboxypeptidase (angiotensinase C) -3.42706
NUP93 nucleoporin 93kDa -3.40952
GLOD4 glyoxalase domain containing 4 -3.36121
KIFBP kinesin family binding protein -3.17144
ISOC1 isochorismatase domain containing 1 -3.10688
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.05541
LDHD lactate dehydrogenase D -3.04839
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -3.0263
GOLT1B golgi transport 1B -2.98306
TBPL1 TBP-like 1 -2.93431
FAIM Fas apoptotic inhibitory molecule -2.8998
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.87651
SNX11 sorting nexin 11 -2.85651
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.85097
CAB39 calcium binding protein 39 -2.84693
RAB21 RAB21, member RAS oncogene family -2.82415
ELAC2 elaC ribonuclease Z 2 -2.82236
ENOPH1 enolase-phosphatase 1 -2.78925
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -2.74745
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.73101
EAPP E2F-associated phosphoprotein -2.69856
TM9SF3 transmembrane 9 superfamily member 3 -2.69685
CDPF1 cysteine-rich, DPF motif domain containing 1 -2.67964
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.67856
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.6772
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.63615
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.53898
MAT2A methionine adenosyltransferase II, alpha -2.52583
HMGA2 high mobility group AT-hook 2 -2.52006
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.51875
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.45787
GDF15 growth differentiation factor 15 -2.4187
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.4018
NRIP1 nuclear receptor interacting protein 1 -2.37977
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.37667
MRPL18 mitochondrial ribosomal protein L18 -2.37393
TOMM34 translocase of outer mitochondrial membrane 34 -2.36274
SOAT2 sterol O-acyltransferase 2 -2.34856
ACTA2 actin, alpha 2, smooth muscle, aorta -2.33612
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.3289
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -2.31447
DENND10 DENN domain containing 10 -2.30704
DDB2 damage-specific DNA binding protein 2, 48kDa -2.29366
HSPA1A heat shock 70kDa protein 1A -2.28756
ZDHHC6 zinc finger, DHHC-type containing 6 -2.27109
GRID1 glutamate receptor, ionotropic, delta 1 -2.27018
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.26917
ZFAND1 zinc finger, AN1-type domain 1 -2.25142
ZMIZ1 zinc finger, MIZ-type containing 1 -2.24451
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -2.21886
TMEM39B transmembrane protein 39B -2.19278
TPM1 tropomyosin 1 (alpha) -2.17895
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.1786
GNAS GNAS complex locus -2.16175
TLR4 toll-like receptor 4 -2.15804
MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase -2.10741
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough -2.0969
PPP6C protein phosphatase 6, catalytic subunit -2.07335
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.07227
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.0721
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.06368
ANXA7 annexin A7 -2.05972
SMNDC1 survival motor neuron domain containing 1 -2.05903
SLC35F2 solute carrier family 35, member F2 -2.04591
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.04092
RXYLT1 ribitol xylosyltransferase 1 -2.03216
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.0313
AGMAT agmatine ureohydrolase (agmatinase) -2.02695
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.02672
ERVMER34-1 endogenous retrovirus group MER34, member 1 -2.0227
RBKS ribokinase -2.01559
ECH1 enoyl CoA hydratase 1, peroxisomal -2.0152
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.00537