CRCGN010_HEPG2_24H:P04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 5.05 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

63 genes differentially expressed following the CRCGN010_HEPG2_24H:P04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ATP11B ATPase, class VI, type 11B 6.67905
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 4.85784
EGF epidermal growth factor 4.60698
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 4.13552
STAP2 signal transducing adaptor family member 2 3.61605
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.15531
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.84759
STK10 serine/threonine kinase 10 2.78126
HEBP1 heme binding protein 1 2.76869
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.7275
TXNRD1 thioredoxin reductase 1 2.7273
ADGRE5 adhesion G protein-coupled receptor E5 2.69817
UGDH UDP-glucose 6-dehydrogenase 2.61742
TIAM1 T-cell lymphoma invasion and metastasis 1 2.49908
GATA3 GATA binding protein 3 2.43855
LUC7L2 LUC7-like 2 (S. cerevisiae) 2.33495
TREM1 triggering receptor expressed on myeloid cells 1 2.31647
PPARG peroxisome proliferator-activated receptor gamma 2.26217
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.2405
ITFG1 integrin alpha FG-GAP repeat containing 1 2.17961
GPBP1L1 GC-rich promoter binding protein 1-like 1 2.15958
PLS1 plastin 1 2.12551
ARID4B AT rich interactive domain 4B (RBP1-like) 2.08141
CHEK2 checkpoint kinase 2 2.00918
PUM1 pumilio RNA-binding family member 1 2.00017

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.31945
RFC2 replication factor C (activator 1) 2, 40kDa -4.71952
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.66226
GTPBP8 GTP-binding protein 8 (putative) -4.45886
NISCH nischarin -4.19424
LOC124907782 dual specificity protein phosphatase 22 -4.1255
ITGB1BP1 integrin beta 1 binding protein 1 -4.0986
TLCD3A TLC domain containing 3A -3.70315
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -3.67297
WDR7 WD repeat domain 7 -3.35496
CASP3 caspase 3, apoptosis-related cysteine peptidase -3.22801
SNX11 sorting nexin 11 -3.20061
KDM3A lysine (K)-specific demethylase 3A -3.13748
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.10953
CCNB2 cyclin B2 -3.07611
CRELD2 cysteine-rich with EGF-like domains 2 -2.99531
THAP11 THAP domain containing 11 -2.96811
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.95554
TUBB6 tubulin, beta 6 class V -2.66989
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.62047
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.55706
FASTKD5 FAST kinase domains 5 -2.47773
CCDC86 coiled-coil domain containing 86 -2.46817
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.44031
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.43963
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -2.38597
NGRN neugrin, neurite outgrowth associated -2.3291
HYOU1 hypoxia up-regulated 1 -2.31944
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.24603
TTLL1 tubulin tyrosine ligase-like family member 1 -2.21889
GNAS GNAS complex locus -2.21603
PCNA proliferating cell nuclear antigen -2.20505
DERA deoxyribose-phosphate aldolase (putative) -2.16859
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.13741
ANOS1 anosmin 1 -2.11895
PXDC1 PX domain containing 1 -2.04641
YME1L1 YME1-like 1 ATPase -2.03519
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -2.01961