CRCGN010_HEPG2_24H:P05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description oxymetholone 2.52 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

241 genes differentially expressed following the CRCGN010_HEPG2_24H:P05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NMU neuromedin U 5.90316
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 5.53096
MEST mesoderm specific transcript 5.4865
LPAR2 lysophosphatidic acid receptor 2 5.36842
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 5.00388
C2CD2 C2 calcium-dependent domain containing 2 4.66809
GSTZ1 glutathione S-transferase zeta 1 4.55854
RPP38 ribonuclease P/MRP 38kDa subunit 4.15872
ZFP36 ZFP36 ring finger protein 4.05386
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 3.88782
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 3.69405
MYC v-myc avian myelocytomatosis viral oncogene homolog 3.66713
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 3.65318
VGLL4 vestigial-like family member 4 3.58495
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 3.57407
PFKL phosphofructokinase, liver 3.52862
MSRA methionine sulfoxide reductase A 3.52675
CREG1 cellular repressor of E1A-stimulated genes 1 3.5051
BAD BCL2-associated agonist of cell death 3.46986
AMDHD2 amidohydrolase domain containing 2 3.34366
ALDOC aldolase C, fructose-bisphosphate 3.34151
HMG20B high mobility group 20B 3.24166
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 3.24038
NT5DC2 5'-nucleotidase domain containing 2 3.23517
TMEM109 transmembrane protein 109 3.16957
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.1223
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.12101
CTSL cathepsin L 3.03346
NNT nicotinamide nucleotide transhydrogenase 3.01479
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.98684
UFC1 ubiquitin-fold modifier conjugating enzyme 1 2.96335
ZNF692 zinc finger protein 692 2.84478
SCARB1 scavenger receptor class B, member 1 2.80651
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.80191
PEX11A peroxisomal biogenesis factor 11 alpha 2.77366
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 2.75952
TRAP1 TNF receptor-associated protein 1 2.74401
ANKRD10 ankyrin repeat domain 10 2.73105
MCOLN1 mucolipin 1 2.69468
GALE UDP-galactose-4-epimerase 2.69397
NLRP2B NLR family pyrin domain containing 2B 2.69168
VTI1B vesicle transport through interaction with t-SNAREs 1B 2.64926
ANO1 anoctamin 1, calcium activated chloride channel 2.64488
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 2.63681
TRAPPC3 trafficking protein particle complex 3 2.63558
MRPS2 mitochondrial ribosomal protein S2 2.61549
PNKP polynucleotide kinase 3'-phosphatase 2.60844
TAGLN2 transgelin 2 2.60759
ZNF83 zinc finger protein 83 2.53971
TCTA T-cell leukemia translocation altered 2.50326
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.50283
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.50121
POLR2J3 polymerase (RNA) II (DNA directed) polypeptide J3 2.47289
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.46897
CASC3 cancer susceptibility candidate 3 2.45534
ABHD4 abhydrolase domain containing 4 2.43811
PDLIM1 PDZ and LIM domain 1 2.43748
BTBD2 BTB (POZ) domain containing 2 2.3964
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.37233
JADE2 jade family PHD finger 2 2.369
PGM1 phosphoglucomutase 1 2.36778
ARFIP2 ADP-ribosylation factor interacting protein 2 2.36518
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 2.3592
UBE3C ubiquitin protein ligase E3C 2.34167
NEMF nuclear export mediator factor 2.31706
CALML5 calmodulin-like 5 2.31414
CTSV cathepsin V 2.30747
MOSPD3 motile sperm domain containing 3 2.30552
BPHL biphenyl hydrolase-like (serine hydrolase) 2.29604
PRKCD protein kinase C, delta 2.28591
ABHD17A abhydrolase domain containing 17A 2.27817
SHB Src homology 2 domain containing adaptor protein B 2.27596
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.27242
TUBB4B tubulin, beta 4B class IVb 2.26356
RNF220 ring finger protein 220 2.26138
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa 2.2601
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma 2.25854
FAM117A family with sequence similarity 117, member A 2.25095
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.24369
GTF2A2 general transcription factor IIA, 2, 12kDa 2.23371
RXRA retinoid X receptor, alpha 2.20647
ICE1 interactor of little elongation complex ELL subunit 1 2.1988
CAPN9 calpain 9 2.19422
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.18838
DNAAF2 dynein, axonemal, assembly factor 2 2.18401
KXD1 KxDL motif containing 1 2.18041
ZNF274 zinc finger protein 274 2.17243
DMRT1 doublesex and mab-3 related transcription factor 1 2.16822
BLCAP bladder cancer associated protein 2.16274
COG2 component of oligomeric golgi complex 2 2.16013
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 2.15935
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.1557
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 2.15463
KLHDC3 kelch domain containing 3 2.15294
NISCH nischarin 2.12704
RNF130 ring finger protein 130 2.12503
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 2.11991
CLN3 ceroid-lipofuscinosis, neuronal 3 2.1132
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.10938
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.10734
TMCC2 transmembrane and coiled-coil domain family 2 2.09593
MINDY1 MINDY lysine 48 deubiquitinase 1 2.09263
GDE1 glycerophosphodiester phosphodiesterase 1 2.08968
CBR1 carbonyl reductase 1 2.08435
PYGL phosphorylase, glycogen, liver 2.08413
ZFYVE26 zinc finger, FYVE domain containing 26 2.08354
SALL1 spalt-like transcription factor 1 2.08079
CENPU centromere protein U 2.08032
TRIM13 tripartite motif containing 13 2.07711
TRIP6 thyroid hormone receptor interactor 6 2.07641
H2AZ1 H2A.Z variant histone 1 2.06407
LTA4H leukotriene A4 hydrolase 2.0541
TUBA3C tubulin, alpha 3c 2.05151
CHURC1-FNTB CHURC1-FNTB readthrough 2.0486
ZNF23 zinc finger protein 23 2.04331
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 2.04065
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.03055
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.02948
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.02615
ANAPC5 anaphase promoting complex subunit 5 2.025
EMC3 ER membrane protein complex subunit 3 2.02232
EIF2D eukaryotic translation initiation factor 2D 2.01976
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.01879
MRPL12 mitochondrial ribosomal protein L12 2.0078
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 2.00447
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.00241
CCDC86 coiled-coil domain containing 86 2.00013

decreased expression

Symbol Name Standardized Value
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -9.80118
CCNB2 cyclin B2 -8.75888
ZNF586 zinc finger protein 586 -8.12503
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) -6.02166
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.64807
GLOD4 glyoxalase domain containing 4 -5.24147
LDHD lactate dehydrogenase D -5.07705
TM9SF2 transmembrane 9 superfamily member 2 -4.77251
CAB39 calcium binding protein 39 -4.45422
PRCP prolylcarboxypeptidase (angiotensinase C) -4.23376
CDPF1 cysteine-rich, DPF motif domain containing 1 -4.14751
CD320 CD320 molecule -3.95328
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.94305
SOAT2 sterol O-acyltransferase 2 -3.83648
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.66984
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.65987
NGRN neugrin, neurite outgrowth associated -3.61254
ZW10 zw10 kinetochore protein -3.59216
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -3.53298
SCAND1 SCAN domain containing 1 -3.51326
CRYZ crystallin, zeta (quinone reductase) -3.44987
ENOPH1 enolase-phosphatase 1 -3.3293
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.29441
SLC35F2 solute carrier family 35, member F2 -3.27016
ANXA7 annexin A7 -3.17675
CCNH cyclin H -3.16765
MTFR1 mitochondrial fission regulator 1 -3.16399
SQOR sulfide quinone oxidoreductase -3.15023
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.13576
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.10643
UBQLN2 ubiquilin 2 -3.051
TBPL1 TBP-like 1 -3.02483
VAT1 vesicle amine transport 1 -3.01111
USP22 ubiquitin specific peptidase 22 -3.00738
NUP93 nucleoporin 93kDa -2.99467
ISOC1 isochorismatase domain containing 1 -2.9738
ARID5B AT rich interactive domain 5B (MRF1-like) -2.96824
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -2.95512
FBXL12 F-box and leucine-rich repeat protein 12 -2.95319
HSPA1A heat shock 70kDa protein 1A -2.85654
CHEK1 checkpoint kinase 1 -2.82173
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.78415
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -2.75969
ELAC2 elaC ribonuclease Z 2 -2.74059
IFRD2 interferon-related developmental regulator 2 -2.73556
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.68394
TOMM34 translocase of outer mitochondrial membrane 34 -2.61491
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -2.60445
HYOU1 hypoxia up-regulated 1 -2.5999
TOR1A torsin family 1, member A (torsin A) -2.57757
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.55499
CEMIP2 cell migration inducing hyaluronidase 2 -2.52477
CXCL12 chemokine (C-X-C motif) ligand 12 -2.51303
CASP7 caspase 7, apoptosis-related cysteine peptidase -2.5073
THAP11 THAP domain containing 11 -2.46806
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.46477
CCL21 chemokine (C-C motif) ligand 21 -2.46106
RAB21 RAB21, member RAS oncogene family -2.45829
CKMT1A creatine kinase, mitochondrial 1A -2.4434
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.4248
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 -2.42404
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.41693
TPM1 tropomyosin 1 (alpha) -2.40851
PCOLCE procollagen C-endopeptidase enhancer -2.40146
FAIM Fas apoptotic inhibitory molecule -2.39642
EBNA1BP2 EBNA1 binding protein 2 -2.38125
RXYLT1 ribitol xylosyltransferase 1 -2.38117
MRPL18 mitochondrial ribosomal protein L18 -2.36756
CPNE3 copine III -2.36375
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.36338
DDIT4 DNA-damage-inducible transcript 4 -2.35411
ARCN1 archain 1 -2.35398
CDKN2A cyclin-dependent kinase inhibitor 2A -2.30472
VDAC1 voltage-dependent anion channel 1 -2.286
TATDN2 TatD DNase domain containing 2 -2.2758
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.27405
BCL10 B-cell CLL/lymphoma 10 -2.24902
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.24854
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -2.2365
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic) -2.23527
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -2.22417
TCEAL4 transcription elongation factor A (SII)-like 4 -2.22372
LRRC15 leucine rich repeat containing 15 -2.21353
TCP1 t-complex 1 -2.19356
AEBP1 AE binding protein 1 -2.19201
COQ10B coenzyme Q10 homolog B (S. cerevisiae) -2.18871
NOLC1 nucleolar and coiled-body phosphoprotein 1 -2.18813
BLMH bleomycin hydrolase -2.18803
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.18061
CEMIP cell migration inducing protein, hyaluronan binding -2.17445
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.17138
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -2.17017
SPAG5 sperm associated antigen 5 -2.16363
STAU2 staufen double-stranded RNA binding protein 2 -2.15787
KIFBP kinesin family binding protein -2.15733
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.15629
ZBTB10 zinc finger and BTB domain containing 10 -2.13911
TRH thyrotropin-releasing hormone -2.10802
STRA6 stimulated by retinoic acid 6 -2.10794
RBM22 RNA binding motif protein 22 -2.0935
COQ3 coenzyme Q3 methyltransferase -2.08954
SARAF store-operated calcium entry-associated regulatory factor -2.07919
P3H1 prolyl 3-hydroxylase 1 -2.05492
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.05453
COL16A1 collagen, type XVI, alpha 1 -2.04595
HAT1 histone acetyltransferase 1 -2.04368
TRIB1 tribbles pseudokinase 1 -2.03886
RBKS ribokinase -2.03702
RUVBL1 RuvB-like AAA ATPase 1 -2.02751
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.0275
SUSD4 sushi domain containing 4 -2.02347
AGO2 argonaute RISC catalytic component 2 -2.0171
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.01197
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.00877