| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,4'-methylene-bis(2-chloro?aniline) 38.8 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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129 genes differentially expressed following the CRCGN010_HEPG2_24H:P07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GSTZ1 | glutathione S-transferase zeta 1 | 6.73531 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 6.21972 |
| MAP7 | microtubule-associated protein 7 | 5.15023 |
| NUCB2 | nucleobindin 2 | 5.03036 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 4.96836 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 4.93779 |
| EVL | Enah/Vasp-like | 4.77544 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.75415 |
| SFTPB | surfactant protein B | 4.61267 |
| ABHD4 | abhydrolase domain containing 4 | 4.46794 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 4.46226 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 | 4.21249 |
| CDC45 | cell division cycle 45 | 4.19207 |
| DYRK3 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 | 4.17842 |
| RAP1GAP | RAP1 GTPase activating protein | 4.13255 |
| TRIB3 | tribbles pseudokinase 3 | 4.12151 |
| MTERF3 | mitochondrial transcription termination factor 3 | 3.8719 |
| TXNRD1 | thioredoxin reductase 1 | 3.53944 |
| LCN2 | lipocalin 2 | 3.36348 |
| LSR | lipolysis stimulated lipoprotein receptor | 3.34339 |
| MVP | major vault protein | 3.302 |
| CTSL | cathepsin L | 3.16149 |
| CYCS | cytochrome c, somatic | 3.14886 |
| ZNF589 | zinc finger protein 589 | 3.12297 |
| NOTCH1 | notch 1 | 3.10351 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.99445 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.95998 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.94386 |
| AARS1 | alanyl-tRNA synthetase 1 | 2.92063 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.88006 |
| STIMATE | STIM activating enhancer | 2.87378 |
| MAMLD1 | mastermind-like domain containing 1 | 2.84143 |
| PHGDH | phosphoglycerate dehydrogenase | 2.80781 |
| LAGE3 | L antigen family, member 3 | 2.76587 |
| ZW10 | zw10 kinetochore protein | 2.75428 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.74392 |
| SQSTM1 | sequestosome 1 | 2.73771 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.66595 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 2.61737 |
| RXYLT1 | ribitol xylosyltransferase 1 | 2.44461 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | 2.42577 |
| DYRK4 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 | 2.42259 |
| TM9SF2 | transmembrane 9 superfamily member 2 | 2.42 |
| IQCB1 | IQ motif containing B1 | 2.41445 |
| CNPY3 | canopy FGF signaling regulator 3 | 2.39082 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 2.3715 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.35942 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.33019 |
| MCM3 | minichromosome maintenance complex component 3 | 2.27977 |
| PYGB | phosphorylase, glycogen; brain | 2.19485 |
| WFDC1 | WAP four-disulfide core domain 1 | 2.18556 |
| VAT1 | vesicle amine transport 1 | 2.1822 |
| TTC17 | tetratricopeptide repeat domain 17 | 2.17129 |
| MGAT4B | mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B | 2.15458 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 2.10271 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 2.10069 |
| METTL8 | methyltransferase like 8 | 2.06291 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 2.05228 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 2.03293 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.02229 |
| COG7 | component of oligomeric golgi complex 7 | 2.01357 |
| GTPBP2 | GTP binding protein 2 | 2.00488 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDC20 | cell division cycle 20 | -9.78224 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -9.58021 |
| MELK | maternal embryonic leucine zipper kinase | -6.30411 |
| CDK1 | cyclin-dependent kinase 1 | -5.13405 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -5.09154 |
| NRIP1 | nuclear receptor interacting protein 1 | -4.89689 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -4.84737 |
| CCNB2 | cyclin B2 | -4.50674 |
| CCNA2 | cyclin A2 | -4.47822 |
| AURKB | aurora kinase B | -4.33636 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -4.31963 |
| PLK1 | polo-like kinase 1 | -4.28256 |
| STMN1 | stathmin 1 | -3.92256 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.88513 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -3.87369 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -3.86844 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -3.77128 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -3.66645 |
| PGAM4 | phosphoglycerate mutase family member 4 | -3.60757 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -3.60664 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.59301 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -3.58792 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -3.56003 |
| KIF14 | kinesin family member 14 | -3.54469 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.28713 |
| ZNF586 | zinc finger protein 586 | -3.16288 |
| POLR1A | polymerase (RNA) I polypeptide A, 194kDa | -3.08366 |
| LDHD | lactate dehydrogenase D | -3.0772 |
| NFIL3 | nuclear factor, interleukin 3 regulated | -3.07715 |
| CD320 | CD320 molecule | -2.97181 |
| BIRC5 | baculoviral IAP repeat containing 5 | -2.96249 |
| CCNB1 | cyclin B1 | -2.92268 |
| SLC35F2 | solute carrier family 35, member F2 | -2.90908 |
| LBR | lamin B receptor | -2.89313 |
| FBXO7 | F-box protein 7 | -2.62847 |
| PEG10 | paternally expressed 10 | -2.62255 |
| AURKA | aurora kinase A | -2.54616 |
| KIF11 | kinesin family member 11 | -2.49538 |
| CDCA8 | cell division cycle associated 8 | -2.49471 |
| ZNF274 | zinc finger protein 274 | -2.43499 |
| YME1L1 | YME1-like 1 ATPase | -2.43004 |
| ECT2 | epithelial cell transforming 2 | -2.38464 |
| GNAS | GNAS complex locus | -2.37172 |
| KIF4A | kinesin family member 4A | -2.32755 |
| SNX11 | sorting nexin 11 | -2.3185 |
| PIMREG | PICALM interacting mitotic regulator | -2.29711 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -2.26905 |
| DERA | deoxyribose-phosphate aldolase (putative) | -2.26681 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -2.26485 |
| DCK | deoxycytidine kinase | -2.26359 |
| CHEK1 | checkpoint kinase 1 | -2.25699 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -2.22708 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.17232 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.12721 |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | -2.1002 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.0975 |
| RPIA | ribose 5-phosphate isomerase A | -2.09705 |
| SMC4 | structural maintenance of chromosomes 4 | -2.09614 |
| ZNF143 | zinc finger protein 143 | -2.09378 |
| MYL9 | myosin, light chain 9, regulatory | -2.07673 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -2.06469 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -2.06221 |
| FBXO5 | F-box protein 5 | -2.05136 |
| DHX29 | DEAH (Asp-Glu-Ala-His) box polypeptide 29 | -2.02876 |
| FIRRM | FIGNL1 interacting regulator of recombination and mitosis | -2.02503 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.02246 |
| DEPDC1 | DEP domain containing 1 | -2.00709 |
