| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 4,4'-methylene-bis(2-chloro?aniline) 19.4 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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63 genes differentially expressed following the CRCGN010_HEPG2_24H:P08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 10.0 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 6.74633 |
| NUCB2 | nucleobindin 2 | 4.98111 |
| ABHD4 | abhydrolase domain containing 4 | 4.36912 |
| STAP2 | signal transducing adaptor family member 2 | 3.84216 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.82774 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.77367 |
| NOSIP | nitric oxide synthase interacting protein | 3.58402 |
| STIMATE | STIM activating enhancer | 3.57624 |
| CYCS | cytochrome c, somatic | 3.50892 |
| NFIL3 | nuclear factor, interleukin 3 regulated | 3.37822 |
| STK10 | serine/threonine kinase 10 | 3.23204 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 2.94905 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 2.84622 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.82891 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | 2.82259 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 2.79961 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.78588 |
| EPHB2 | EPH receptor B2 | 2.62533 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.57008 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.54046 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | 2.42362 |
| TMEM50A | transmembrane protein 50A | 2.31614 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.24302 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.22616 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | 2.17689 |
| SLC25A46 | solute carrier family 25, member 46 | 2.16575 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 2.15857 |
| MAP7 | microtubule-associated protein 7 | 2.1133 |
| KIN | Kin17 DNA and RNA binding protein | 2.09541 |
| HSPA1A | heat shock 70kDa protein 1A | 2.05278 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.04266 |
| SLC75A1 | solute carrier family 75 member 1 | 2.03503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OXA1L | oxidase (cytochrome c) assembly 1-like | -6.43448 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | -4.92555 |
| FAIM | Fas apoptotic inhibitory molecule | -4.11074 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.95357 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -3.70621 |
| LDHD | lactate dehydrogenase D | -3.67788 |
| ZNF586 | zinc finger protein 586 | -3.52752 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase | -3.31216 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.30648 |
| WDR7 | WD repeat domain 7 | -3.30138 |
| GTPBP8 | GTP-binding protein 8 (putative) | -3.29178 |
| CCNB2 | cyclin B2 | -3.26551 |
| CDC20 | cell division cycle 20 | -3.183 |
| CCNB1 | cyclin B1 | -3.15225 |
| DNTTIP2 | deoxynucleotidyltransferase, terminal, interacting protein 2 | -2.91393 |
| NUP85 | nucleoporin 85kDa | -2.88784 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | -2.78292 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -2.75399 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.67064 |
| CD320 | CD320 molecule | -2.57749 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.53482 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.44356 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -2.22789 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -2.14136 |
| SAP30BP | SAP30 binding protein | -2.13485 |
| MELK | maternal embryonic leucine zipper kinase | -2.12114 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -2.10442 |
| EIF4H | eukaryotic translation initiation factor 4H | -2.1028 |
| NGRN | neugrin, neurite outgrowth associated | -2.08707 |
| MRPL58 | mitochondrial ribosomal protein L58 | -2.07479 |
