CRCGN010_HEPG2_24H:P09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 9.7 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

51 genes differentially expressed following the CRCGN010_HEPG2_24H:P09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GATA3 GATA binding protein 3 6.10392
MAP7 microtubule-associated protein 7 5.67149
AMDHD2 amidohydrolase domain containing 2 5.45907
PRR15L proline rich 15-like 5.4373
NUCB2 nucleobindin 2 5.05638
CSK c-src tyrosine kinase 3.99907
PPARG peroxisome proliferator-activated receptor gamma 3.97871
JADE2 jade family PHD finger 2 3.87026
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.71221
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.62956
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.57503
NOTCH1 notch 1 3.42572
ATP11B ATPase, class VI, type 11B 3.41979
EPN2 epsin 2 3.26791
GPER1 G protein-coupled estrogen receptor 1 3.2673
GSTZ1 glutathione S-transferase zeta 1 3.21702
HOXA10 homeobox A10 2.95172
CHMP6 charged multivesicular body protein 6 2.88701
LCN2 lipocalin 2 2.83081
CAPN1 calpain 1, (mu/I) large subunit 2.7898
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.77893
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.71402
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.58903
LYN LYN proto-oncogene, Src family tyrosine kinase 2.52297
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.36392
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.29165
NOSIP nitric oxide synthase interacting protein 2.24799
TIAM1 T-cell lymphoma invasion and metastasis 1 2.19181
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.15311
LOC122526780 uncharacterized LOC122526780 2.14162
KDM5A lysine (K)-specific demethylase 5A 2.09309

decreased expression

Symbol Name Standardized Value
LAP3 leucine aminopeptidase 3 -4.41126
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.80036
OXA1L oxidase (cytochrome c) assembly 1-like -3.64949
LDHD lactate dehydrogenase D -3.50093
TSPAN4 tetraspanin 4 -3.39355
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.12469
CCDC86 coiled-coil domain containing 86 -3.10285
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -3.08045
ZNF586 zinc finger protein 586 -3.03602
CCNB2 cyclin B2 -3.02415
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -2.94446
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -2.89582
ITGB1BP1 integrin beta 1 binding protein 1 -2.83302
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.67813
SLC35F2 solute carrier family 35, member F2 -2.63191
FOS FBJ murine osteosarcoma viral oncogene homolog -2.46725
PCNA proliferating cell nuclear antigen -2.30203
RFC2 replication factor C (activator 1) 2, 40kDa -2.15948
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.1443
KDM1A lysine (K)-specific demethylase 1A -2.11853