CRCGN010_HEPG2_24H:P10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4,4'-methylene-bis(2-chloro?aniline) 4.85 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN010_HEPG2_24H:P10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 6.18692
MAP7 microtubule-associated protein 7 5.6163
CYCS cytochrome c, somatic 4.49413
UBQLN2 ubiquilin 2 4.05219
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.83798
NOSIP nitric oxide synthase interacting protein 3.79395
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.56632
MYLK myosin light chain kinase 3.49391
LOC122526780 uncharacterized LOC122526780 3.34376
GADD45A growth arrest and DNA-damage-inducible, alpha 3.1324
RPL39L ribosomal protein L39-like 2.97211
CXCL2 chemokine (C-X-C motif) ligand 2 2.78124
CRTAP cartilage associated protein 2.74638
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.48711
NUCB2 nucleobindin 2 2.43807
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 2.43252
PPARG peroxisome proliferator-activated receptor gamma 2.29605
SFTPB surfactant protein B 2.26219
CIAO3 cytosolic iron-sulfur assembly component 3 2.20978
CCL2 chemokine (C-C motif) ligand 2 2.1667
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.15728
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.13035
ZFP36 ZFP36 ring finger protein 2.12039
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.06288
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.02259

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -7.1269
CCNB2 cyclin B2 -6.25201
CDC20 cell division cycle 20 -5.28735
DNM1L dynamin 1-like -3.78405
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.65213
HMG20B high mobility group 20B -3.56247
CCNB1 cyclin B1 -3.56091
CD320 CD320 molecule -3.46716
ZNF586 zinc finger protein 586 -3.22772
PCNA proliferating cell nuclear antigen -3.17315
GDF15 growth differentiation factor 15 -3.00893
LDHD lactate dehydrogenase D -2.92367
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.8687
RFC2 replication factor C (activator 1) 2, 40kDa -2.84055
ZMIZ1 zinc finger, MIZ-type containing 1 -2.80373
TLR4 toll-like receptor 4 -2.77335
GNAS GNAS complex locus -2.65178
DERA deoxyribose-phosphate aldolase (putative) -2.50255
MAPK13 mitogen-activated protein kinase 13 -2.47254
TRAPPC6A trafficking protein particle complex 6A -2.42422
PPOX protoporphyrinogen oxidase -2.14183