| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (s)-cyano(3-phenoxyphenyl)methyl (1r,3r)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate 20.15 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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61 genes differentially expressed following the CRCGN010_HEPG2_24H:P13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 6.92664 |
| P4HTM | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | 5.90127 |
| MAP7 | microtubule-associated protein 7 | 5.5824 |
| AMDHD2 | amidohydrolase domain containing 2 | 4.10715 |
| PPARG | peroxisome proliferator-activated receptor gamma | 3.51688 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 3.42593 |
| GPATCH8 | G patch domain containing 8 | 3.39735 |
| MELK | maternal embryonic leucine zipper kinase | 3.33363 |
| MYLK | myosin light chain kinase | 3.30512 |
| PCDHB11 | protocadherin beta 11 | 3.30101 |
| KLHL21 | kelch-like family member 21 | 3.26729 |
| PNKP | polynucleotide kinase 3'-phosphatase | 3.26515 |
| CHMP6 | charged multivesicular body protein 6 | 3.26473 |
| CSK | c-src tyrosine kinase | 3.10103 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 3.0139 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 2.94176 |
| ABHD6 | abhydrolase domain containing 6 | 2.93249 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.88332 |
| HMOX1 | heme oxygenase 1 | 2.84341 |
| BZW2 | basic leucine zipper and W2 domains 2 | 2.8346 |
| DIPK1A | divergent protein kinase domain 1A | 2.79974 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 2.71282 |
| GSTZ1 | glutathione S-transferase zeta 1 | 2.67133 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 2.65062 |
| LSR | lipolysis stimulated lipoprotein receptor | 2.59578 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 2.41883 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.36858 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.33977 |
| IDE | insulin-degrading enzyme | 2.3107 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.29636 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.24744 |
| CHN1 | chimerin 1 | 2.18586 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.11648 |
| PRR15L | proline rich 15-like | 2.04988 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.01026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CTSD | cathepsin D | -4.23313 |
| HAT1 | histone acetyltransferase 1 | -4.00773 |
| PLK1 | polo-like kinase 1 | -3.96993 |
| ISOC1 | isochorismatase domain containing 1 | -3.83326 |
| CPSF4 | cleavage and polyadenylation specific factor 4, 30kDa | -3.49497 |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 | -3.45053 |
| MRPS2 | mitochondrial ribosomal protein S2 | -3.4129 |
| ZNF586 | zinc finger protein 586 | -3.30292 |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | -3.13886 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.12249 |
| IDH1 | isocitrate dehydrogenase 1 (NADP+), soluble | -3.01165 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.97871 |
| LDHD | lactate dehydrogenase D | -2.87186 |
| PCNA | proliferating cell nuclear antigen | -2.81895 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.79774 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.70112 |
| WASHC4 | WASH complex subunit 4 | -2.5632 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -2.5151 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -2.51224 |
| HSPB1 | heat shock 27kDa protein 1 | -2.49896 |
| VDAC1 | voltage-dependent anion channel 1 | -2.41799 |
| CDC25B | cell division cycle 25B | -2.29117 |
| FGGY | FGGY carbohydrate kinase domain containing | -2.25117 |
| TOR1A | torsin family 1, member A (torsin A) | -2.24866 |
| IFRD2 | interferon-related developmental regulator 2 | -2.12848 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -2.12733 |
