CRCGN010_HEPG2_24H:P14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description (s)-cyano(3-phenoxyphenyl)methyl (1r,3r)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate 10.08 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN010_HEPG2_24H:P14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 6.07998
ADRB2 adrenoceptor beta 2, surface 4.39221
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 3.86234
PNKP polynucleotide kinase 3'-phosphatase 3.69667
LOC122526780 uncharacterized LOC122526780 3.4552
NOSIP nitric oxide synthase interacting protein 3.18982
SFTPB surfactant protein B 3.11071
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.10953
EPHA3 EPH receptor A3 3.0961
HOXA10 homeobox A10 2.81375
CHMP6 charged multivesicular body protein 6 2.79505
UFM1 ubiquitin-fold modifier 1 2.78672
STK10 serine/threonine kinase 10 2.6104
VGLL4 vestigial-like family member 4 2.53044
HSPA1A heat shock 70kDa protein 1A 2.32232
STXBP2 syntaxin binding protein 2 2.25128
PRR15L proline rich 15-like 2.22078
GPATCH8 G patch domain containing 8 2.20891
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.19
TREM1 triggering receptor expressed on myeloid cells 1 2.18105
LPAR2 lysophosphatidic acid receptor 2 2.10822
CD40 CD40 molecule, TNF receptor superfamily member 5 2.057
EGF epidermal growth factor 2.05542

decreased expression

Symbol Name Standardized Value
TARBP1 TAR (HIV-1) RNA binding protein 1 -7.6754
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -7.60549
TLR4 toll-like receptor 4 -5.00274
KDM3A lysine (K)-specific demethylase 3A -4.40385
TSPAN4 tetraspanin 4 -4.40287
CCNB2 cyclin B2 -4.00617
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.99676
VAT1 vesicle amine transport 1 -3.99326
HSPB1 heat shock 27kDa protein 1 -3.89371
LDHD lactate dehydrogenase D -3.81418
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -3.67291
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -3.66666
PEG10 paternally expressed 10 -2.87767
PRPF4 pre-mRNA processing factor 4 -2.79755
TLCD3A TLC domain containing 3A -2.72176
GARS1 glycyl-tRNA synthetase 1 -2.29742
GNAS GNAS complex locus -2.2308
ZNF586 zinc finger protein 586 -2.13115
NCAPD2 non-SMC condensin I complex, subunit D2 -2.12128
UBE2C ubiquitin-conjugating enzyme E2C -2.09908
ITGB1BP1 integrin beta 1 binding protein 1 -2.08228
NT5E 5'-nucleotidase, ecto (CD73) -2.00307