| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (s)-cyano(3-phenoxyphenyl)methyl (1r,3r)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate 5.04 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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60 genes differentially expressed following the CRCGN010_HEPG2_24H:P15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NMU | neuromedin U | 4.43714 |
| MYLK | myosin light chain kinase | 4.29046 |
| NOTCH1 | notch 1 | 4.20984 |
| LAGE3 | L antigen family, member 3 | 4.06683 |
| CYCS | cytochrome c, somatic | 3.9075 |
| LCN2 | lipocalin 2 | 3.74499 |
| AMDHD2 | amidohydrolase domain containing 2 | 3.64152 |
| MAMLD1 | mastermind-like domain containing 1 | 3.63343 |
| DENND2D | DENN/MADD domain containing 2D | 3.53451 |
| ATP11B | ATPase, class VI, type 11B | 3.51077 |
| RPP38 | ribonuclease P/MRP 38kDa subunit | 3.43218 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 3.38241 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 3.36939 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.23185 |
| ABHD6 | abhydrolase domain containing 6 | 3.21614 |
| MEF2C | myocyte enhancer factor 2C | 3.08452 |
| PRR15L | proline rich 15-like | 3.07585 |
| H2BC12 | H2B clustered histone 12 | 2.74526 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 2.66813 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.55123 |
| CASP10 | caspase 10, apoptosis-related cysteine peptidase | 2.42601 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 2.28417 |
| HLA-DMA | major histocompatibility complex, class II, DM alpha | 2.28395 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.28015 |
| CCN2 | cellular communication network factor 2 | 2.26606 |
| EGF | epidermal growth factor | 2.24328 |
| CCNH | cyclin H | 2.18112 |
| SH2B3 | SH2B adaptor protein 3 | 2.16249 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.09373 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 2.07984 |
| CISD1 | CDGSH iron sulfur domain 1 | 2.06924 |
| MTERF3 | mitochondrial transcription termination factor 3 | 2.06692 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF586 | zinc finger protein 586 | -8.72907 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -7.38495 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | -7.37465 |
| TRIB3 | tribbles pseudokinase 3 | -6.69447 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -5.74598 |
| CCNB1 | cyclin B1 | -4.48979 |
| TLR4 | toll-like receptor 4 | -4.18663 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -4.08075 |
| KDM3A | lysine (K)-specific demethylase 3A | -3.94885 |
| DSG2 | desmoglein 2 | -3.93442 |
| CNDP2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | -3.48894 |
| EIF5 | eukaryotic translation initiation factor 5 | -3.07521 |
| CD320 | CD320 molecule | -2.7895 |
| MVP | major vault protein | -2.73314 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.73022 |
| GNAS | GNAS complex locus | -2.71719 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.7048 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -2.50094 |
| CAPNS1 | calpain, small subunit 1 | -2.4512 |
| FGFR4 | fibroblast growth factor receptor 4 | -2.43065 |
| TMEM147 | transmembrane protein 147 | -2.39413 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.34377 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -2.34319 |
| TLE1 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) | -2.20805 |
| ZNF134 | zinc finger protein 134 | -2.15556 |
| ZNF559-ZNF177 | ZNF559-ZNF177 readthrough | -2.09184 |
| SNX11 | sorting nexin 11 | -2.02737 |
| LOC122539214 | Zinc finger protein LOC122539214 | -2.0174 |
