| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | (s)-cyano(3-phenoxyphenyl)methyl (1r,3r)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate 1.26 um perturbation at 24 h in HEPG2 (Carcinogenome) |
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56 genes differentially expressed following the CRCGN010_HEPG2_24H:P17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 4.76998 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 3.66664 |
| ATP11B | ATPase, class VI, type 11B | 3.5269 |
| HYOU1 | hypoxia up-regulated 1 | 3.38641 |
| HSPA1A | heat shock 70kDa protein 1A | 3.3181 |
| WDR7 | WD repeat domain 7 | 3.25065 |
| CHMP6 | charged multivesicular body protein 6 | 3.24172 |
| EPHB2 | EPH receptor B2 | 3.21186 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.16718 |
| DENND2D | DENN/MADD domain containing 2D | 3.14049 |
| TATDN2 | TatD DNase domain containing 2 | 2.9637 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.95357 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 2.81682 |
| PEX11A | peroxisomal biogenesis factor 11 alpha | 2.81286 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 2.79874 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.7053 |
| SH3D19 | SH3 domain containing 19 | 2.70073 |
| LPAR2 | lysophosphatidic acid receptor 2 | 2.64809 |
| PLS1 | plastin 1 | 2.63278 |
| CTSL | cathepsin L | 2.61975 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.55941 |
| HMOX1 | heme oxygenase 1 | 2.49893 |
| ELAC2 | elaC ribonuclease Z 2 | 2.48781 |
| SOCS2 | suppressor of cytokine signaling 2 | 2.34411 |
| ADRB2 | adrenoceptor beta 2, surface | 2.24229 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 2.22757 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.17431 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 2.16885 |
| LAMB3 | laminin, beta 3 | 2.10613 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | 2.06914 |
| RPS6KA1 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 2.06868 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LDHD | lactate dehydrogenase D | -6.46741 |
| ZNF586 | zinc finger protein 586 | -6.23818 |
| PCNA | proliferating cell nuclear antigen | -6.1727 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -5.19808 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -5.09416 |
| GNAS | GNAS complex locus | -4.90404 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -4.33512 |
| PEG10 | paternally expressed 10 | -3.77989 |
| CCNB2 | cyclin B2 | -3.70397 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -3.43648 |
| UGDH | UDP-glucose 6-dehydrogenase | -3.27916 |
| CDC20 | cell division cycle 20 | -3.22543 |
| RNF167 | ring finger protein 167 | -3.21066 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -2.73509 |
| CCNB1 | cyclin B1 | -2.64211 |
| PDHX | pyruvate dehydrogenase complex, component X | -2.59103 |
| KDM3A | lysine (K)-specific demethylase 3A | -2.52496 |
| MAPK13 | mitogen-activated protein kinase 13 | -2.52146 |
| TCTN1 | tectonic family member 1 | -2.5175 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.51336 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -2.47408 |
| RAI14 | retinoic acid induced 14 | -2.26409 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b | -2.2561 |
| NRIP1 | nuclear receptor interacting protein 1 | -2.18142 |
| CD320 | CD320 molecule | -2.15174 |
