CRCGN010_HEPG2_24H:P19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzoic acid, sodium 40.2 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN010_HEPG2_24H:P19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PMM2 phosphomannomutase 2 4.88511
GSTZ1 glutathione S-transferase zeta 1 4.80641
GPER1 G protein-coupled estrogen receptor 1 3.7905
CHN1 chimerin 1 3.57112
CIAO3 cytosolic iron-sulfur assembly component 3 3.50336
MOK MOK protein kinase 3.43565
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.39576
MEST mesoderm specific transcript 3.25328
CHMP6 charged multivesicular body protein 6 3.10783
GPATCH8 G patch domain containing 8 3.09881
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 3.0569
UBQLN2 ubiquilin 2 3.04083
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.0085
DIPK1A divergent protein kinase domain 1A 2.87007
C2CD2 C2 calcium-dependent domain containing 2 2.69205
HEBP1 heme binding protein 1 2.67328
CARMIL1 capping protein regulator and myosin 1 linker 1 2.66259
STIMATE STIM activating enhancer 2.65976
RAB21 RAB21, member RAS oncogene family 2.65652
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.57199
HSPA1A heat shock 70kDa protein 1A 2.17712
CCNA1 cyclin A1 2.10092
ELAC2 elaC ribonuclease Z 2 2.01168

decreased expression

Symbol Name Standardized Value
ZNF586 zinc finger protein 586 -5.37771
CASP7 caspase 7, apoptosis-related cysteine peptidase -4.82789
TLCD3A TLC domain containing 3A -4.36275
WASHC4 WASH complex subunit 4 -3.92563
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.90356
TSPAN4 tetraspanin 4 -3.85167
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.77157
TCERG1 transcription elongation regulator 1 -3.68384
UBE3C ubiquitin protein ligase E3C -3.58732
RNF167 ring finger protein 167 -3.49858
LDHD lactate dehydrogenase D -3.38964
TLR4 toll-like receptor 4 -3.32968
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.32958
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.31394
CCNB2 cyclin B2 -3.09376
ISOC1 isochorismatase domain containing 1 -3.08971
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.07571
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -2.93328
CCNB1 cyclin B1 -2.83511
CHMP4B charged multivesicular body protein 4B -2.63215
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.62255
OXA1L oxidase (cytochrome c) assembly 1-like -2.47913
PLA2G15 phospholipase A2, group XV -2.42945
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.38235
PECR peroxisomal trans-2-enoyl-CoA reductase -2.3392
CASP3 caspase 3, apoptosis-related cysteine peptidase -2.2865
ZMIZ1 zinc finger, MIZ-type containing 1 -2.23253
SESN1 sestrin 1 -2.20653
SNX11 sorting nexin 11 -2.19856
SCCPDH saccharopine dehydrogenase (putative) -2.14018
DDIT4 DNA-damage-inducible transcript 4 -2.13949
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.08727
GLOD4 glyoxalase domain containing 4 -2.01889