| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | DMSO perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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92 genes differentially expressed following the CRCGN011_HEPG2_24H:A04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| BACE2 | beta-site APP-cleaving enzyme 2 | 6.041 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 5.4455 |
| E2F2 | E2F transcription factor 2 | 5.1168 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 4.60385 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 4.40375 |
| SRC | SRC proto-oncogene, non-receptor tyrosine kinase | 4.03815 |
| CSK | c-src tyrosine kinase | 4.0173 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 3.6667 |
| EVL | Enah/Vasp-like | 3.59035 |
| SSBP2 | single-stranded DNA binding protein 2 | 3.57538 |
| GSTZ1 | glutathione S-transferase zeta 1 | 3.4744 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 3.41525 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 3.13513 |
| COL11A1 | collagen, type XI, alpha 1 | 3.1292 |
| TESK1 | testis-specific kinase 1 | 3.12665 |
| FCHO1 | FCH domain only 1 | 3.11695 |
| SATB1 | SATB homeobox 1 | 2.9099 |
| FASTKD5 | FAST kinase domains 5 | 2.8011 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 2.7729 |
| CDC45 | cell division cycle 45 | 2.70875 |
| ZNF318 | zinc finger protein 318 | 2.67917 |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 2.6463 |
| TIMM17B | translocase of inner mitochondrial membrane 17 homolog B (yeast) | 2.643 |
| GPER1 | G protein-coupled estrogen receptor 1 | 2.6274 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 2.6094 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.5584 |
| HMOX1 | heme oxygenase 1 | 2.5324 |
| CGRRF1 | cell growth regulator with ring finger domain 1 | 2.51645 |
| PRKCH | protein kinase C, eta | 2.51363 |
| NFATC4 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | 2.50523 |
| CCL2 | chemokine (C-C motif) ligand 2 | 2.4276 |
| RPL39L | ribosomal protein L39-like | 2.3721 |
| CCP110 | centriolar coiled coil protein 110kDa | 2.28445 |
| CTSL | cathepsin L | 2.28285 |
| PLS1 | plastin 1 | 2.2706 |
| HMGA2 | high mobility group AT-hook 2 | 2.1826 |
| SNX7 | sorting nexin 7 | 2.1157 |
| BAD | BCL2-associated agonist of cell death | 2.11555 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 2.06875 |
| STXBP1 | syntaxin binding protein 1 | 2.0591 |
| POLG2 | polymerase (DNA directed), gamma 2, accessory subunit | 2.03812 |
| CTSK | cathepsin K | 2.03725 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | 2.0318 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.62895 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -5.22587 |
| RPS5 | ribosomal protein S5 | -5.0446 |
| CAB39 | calcium binding protein 39 | -4.27095 |
| NGRN | neugrin, neurite outgrowth associated | -3.94555 |
| CD58 | CD58 molecule | -3.70565 |
| MAPK13 | mitogen-activated protein kinase 13 | -3.54295 |
| PCNA | proliferating cell nuclear antigen | -3.51775 |
| NT5DC2 | 5'-nucleotidase domain containing 2 | -3.42085 |
| CIRBP | cold inducible RNA binding protein | -3.23482 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -3.15835 |
| GNAS | GNAS complex locus | -3.12365 |
| DDIT4 | DNA-damage-inducible transcript 4 | -3.10795 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.05515 |
| HEATR1 | HEAT repeat containing 1 | -2.996 |
| REEP5 | receptor accessory protein 5 | -2.73982 |
| TRAPPC6A | trafficking protein particle complex 6A | -2.72585 |
| CTSD | cathepsin D | -2.71695 |
| VDAC1 | voltage-dependent anion channel 1 | -2.66013 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -2.5479 |
| CAPN1 | calpain 1, (mu/I) large subunit | -2.52775 |
| MAP1S | microtubule-associated protein 1S | -2.5236 |
| ZKSCAN4 | zinc finger with KRAB and SCAN domains 4 | -2.48415 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -2.4604 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | -2.4416 |
| PACSIN1 | protein kinase C and casein kinase substrate in neurons 1 | -2.42225 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.41642 |
| LHX6 | LIM homeobox 6 | -2.3305 |
| LOC124907782 | dual specificity protein phosphatase 22 | -2.283 |
| IL1B | interleukin 1, beta | -2.27877 |
| RAB21 | RAB21, member RAS oncogene family | -2.2749 |
| AK5 | adenylate kinase 5 | -2.24305 |
| ESRP2 | epithelial splicing regulatory protein 2 | -2.211 |
| DSN1 | DSN1, MIS12 kinetochore complex component | -2.18305 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -2.16355 |
| RPS8 | ribosomal protein S8 | -2.1625 |
| YAP1 | Yes-associated protein 1 | -2.154 |
| CALHM2 | calcium homeostasis modulator 2 | -2.13383 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) | -2.11405 |
| CEBPD | CCAAT/enhancer binding protein (C/EBP), delta | -2.07545 |
| TEX10 | testis expressed 10 | -2.06935 |
| BCS1L | BC1 (ubiquinol-cytochrome c reductase) synthesis-like | -2.06935 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | -2.06855 |
| MOGAT1 | monoacylglycerol O-acyltransferase 1 | -2.04215 |
| WASHC4 | WASH complex subunit 4 | -2.03097 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -2.01905 |
| NPR1 | natriuretic peptide receptor 1 | -2.0133 |
| TMSB10 | thymosin beta 10 | -2.0078 |
| ENG | endoglin | -2.00575 |
