CRCGN011_HEPG2_24H:A05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

202 genes differentially expressed following the CRCGN011_HEPG2_24H:A05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 10.0
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 5.6545
PLS1 plastin 1 5.21885
RPP38 ribonuclease P/MRP 38kDa subunit 5.0158
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.9804
PPARG peroxisome proliferator-activated receptor gamma 4.7846
SRC SRC proto-oncogene, non-receptor tyrosine kinase 4.77908
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.7461
MAMLD1 mastermind-like domain containing 1 4.35625
CHN1 chimerin 1 4.20875
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.86685
ZDHHC6 zinc finger, DHHC-type containing 6 3.59125
SSBP2 single-stranded DNA binding protein 2 3.4225
STIMATE STIM activating enhancer 3.37235
CTSL cathepsin L 3.3667
TLR4 toll-like receptor 4 3.3292
CYCS cytochrome c, somatic 3.3187
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.2917
NENF neudesin neurotrophic factor 3.26575
NNT nicotinamide nucleotide transhydrogenase 3.19168
KDM5A lysine (K)-specific demethylase 5A 3.1716
ATP11B ATPase, class VI, type 11B 3.13945
MAGEA6 melanoma antigen family A6 3.1375
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.1312
EVL Enah/Vasp-like 3.1215
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.9357
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.90815
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 2.84375
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.8215
CCNF cyclin F 2.80075
NR0B2 nuclear receptor subfamily 0, group B, member 2 2.76465
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.7468
MEST mesoderm specific transcript 2.72465
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.71675
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.71095
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.68245
AFG3L2 AFG3-like AAA ATPase 2 2.59645
FASTKD5 FAST kinase domains 5 2.52565
CCNG1 cyclin G1 2.52225
CCR7 chemokine (C-C motif) receptor 7 2.4972
CHMP6 charged multivesicular body protein 6 2.4551
PMM2 phosphomannomutase 2 2.43635
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.43117
PSKH1 protein serine kinase H1 2.43
MAGEA10 melanoma antigen family A10 2.39795
NISCH nischarin 2.39515
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 2.38233
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 2.3792
BAD BCL2-associated agonist of cell death 2.3778
LOC128966586 pepsin A-4-like 2.37405
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.36385
OVGP1 oviductal glycoprotein 1, 120kDa 2.3609
COLEC12 collectin sub-family member 12 2.35637
AQP5 aquaporin 5 2.35355
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.34105
CCDC86 coiled-coil domain containing 86 2.33135
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 2.33085
JADE2 jade family PHD finger 2 2.32945
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 2.3148
RAP2C RAP2C, member of RAS oncogene family 2.30857
ANKRD17 ankyrin repeat domain 17 2.3054
GPR15 G protein-coupled receptor 15 2.29935
CATSPERB catsper channel auxiliary subunit beta 2.29535
GYG2 glycogenin 2 2.28982
RGN regucalcin 2.276
XAF1 XIAP associated factor 1 2.2753
SIX6 SIX homeobox 6 2.27475
FLRT1 fibronectin leucine rich transmembrane protein 1 2.2653
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.25535
SRPX sushi-repeat containing protein, X-linked 2.24545
CABP5 calcium binding protein 5 2.2369
CCNT1 cyclin T1 2.23475
PDE3B phosphodiesterase 3B, cGMP-inhibited 2.22455
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 2.21345
MFAP1 microfibrillar-associated protein 1 2.20825
CLEC4M C-type lectin domain family 4, member M 2.20075
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.2007
AUH AU RNA binding protein/enoyl-CoA hydratase 2.1944
KRT75 keratin 75, type II 2.1813
ANKRD10 ankyrin repeat domain 10 2.1738
MTM1 myotubularin 1 2.16457
GCM1 glial cells missing homolog 1 (Drosophila) 2.1446
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.1403
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.1388
GLT8D2 glycosyltransferase 8 domain containing 2 2.13725
HSPA1L heat shock 70kDa protein 1-like 2.1275
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.11242
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.1112
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.10505
CIBAR1 CBY1 interacting BAR domain containing 1 2.10292
EEF2 eukaryotic translation elongation factor 2 2.0969
CRLF2 cytokine receptor-like factor 2 2.0922
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.09177
IFI6 interferon, alpha-inducible protein 6 2.09
DLL3 delta-like 3 (Drosophila) 2.08735
ELAVL1 ELAV like RNA binding protein 1 2.0836
ABT1 activator of basal transcription 1 2.08045
UQCRC2 ubiquinol-cytochrome c reductase core protein II 2.07088
PSG2 pregnancy specific beta-1-glycoprotein 2 2.07005
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.06215
CHERP calcium homeostasis endoplasmic reticulum protein 2.06055
PACC1 proton activated chloride channel 1 2.05925
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.05695
CREG1 cellular repressor of E1A-stimulated genes 1 2.05445
ZFY zinc finger protein, Y-linked 2.0515
PCDHB1 protocadherin beta 1 2.0479
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 2.04462
SCARB1 scavenger receptor class B, member 1 2.0411
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.03635
RNF208 ring finger protein 208 2.034
OR1G1 olfactory receptor, family 1, subfamily G, member 1 2.02805
MORC3 MORC family CW-type zinc finger 3 2.02795
ADIPOR2 adiponectin receptor 2 2.0278
NECAB3 N-terminal EF-hand calcium binding protein 3 2.02195
HLA-DRA major histocompatibility complex, class II, DR alpha 2.0208
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 2.0197
ZCCHC2 zinc finger, CCHC domain containing 2 2.01605
ACKR5 atypical chemokine receptor 5 2.0148
CLTC clathrin, heavy chain (Hc) 2.01045
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.00895
MAGED1 melanoma antigen family D1 2.0064
CEP41 centrosomal protein 41kDa 2.0062
MXD3 MAX dimerization protein 3 2.00585
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 2.00152

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -7.47195
GOLT1B golgi transport 1B -6.8196
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -6.03845
KDM3A lysine (K)-specific demethylase 3A -5.8323
SCAND1 SCAN domain containing 1 -5.53925
TSEN2 TSEN2 tRNA splicing endonuclease subunit -5.4375
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.01245
TRIB3 tribbles pseudokinase 3 -5.0
ZW10 zw10 kinetochore protein -4.9234
C2CD5 C2 calcium-dependent domain containing 5 -4.905
LOC124907782 dual specificity protein phosphatase 22 -4.85825
UGDH UDP-glucose 6-dehydrogenase -4.66275
MAP7 microtubule-associated protein 7 -4.54977
CHMP4B charged multivesicular body protein 4B -4.53853
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.42115
TARBP1 TAR (HIV-1) RNA binding protein 1 -3.9273
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.81505
GRWD1 glutamate-rich WD repeat containing 1 -3.4109
TM9SF2 transmembrane 9 superfamily member 2 -3.39325
MRPS2 mitochondrial ribosomal protein S2 -3.35555
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -3.33125
RFC2 replication factor C (activator 1) 2, 40kDa -3.17275
TM9SF3 transmembrane 9 superfamily member 3 -2.75345
STN1 STN1 subunit of CST complex -2.7218
ACAA1 acetyl-CoA acyltransferase 1 -2.70315
MTFR1 mitochondrial fission regulator 1 -2.67803
SURF2 surfeit 2 -2.60835
WASHC4 WASH complex subunit 4 -2.59505
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.5224
PRCP prolylcarboxypeptidase (angiotensinase C) -2.52065
TBCB tubulin folding cofactor B -2.51105
SQOR sulfide quinone oxidoreductase -2.4741
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.4509
PARP6 poly (ADP-ribose) polymerase family, member 6 -2.42145
RPP25 ribonuclease P/MRP 25kDa subunit -2.40245
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.3871
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.35335
UPP1 uridine phosphorylase 1 -2.3339
HSPA1A heat shock 70kDa protein 1A -2.31935
YME1L1 YME1-like 1 ATPase -2.30278
TCEAL4 transcription elongation factor A (SII)-like 4 -2.29415
ZNF430 zinc finger protein 430 -2.2874
MOK MOK protein kinase -2.28395
MSH5 mutS homolog 5 -2.27205
FOS FBJ murine osteosarcoma viral oncogene homolog -2.26895
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 -2.26805
ESM1 endothelial cell-specific molecule 1 -2.2656
APOLD1 apolipoprotein L domain containing 1 -2.25715
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 -2.25685
RBM34 RNA binding motif protein 34 -2.25315
BAG6 BCL2-associated athanogene 6 -2.23517
ZNF611 zinc finger protein 611 -2.23365
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.2226
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.21825
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -2.1818
TBPL1 TBP-like 1 -2.17895
PFKP phosphofructokinase, platelet -2.1661
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.1624
MAP2K5 mitogen-activated protein kinase kinase 5 -2.13612
TM7SF3 transmembrane 7 superfamily member 3 -2.12495
TUBGCP5 tubulin, gamma complex associated protein 5 -2.1219
MFSD1 major facilitator superfamily domain containing 1 -2.12135
CPNE3 copine III -2.11555
BUD31 BUD31 homolog (S. cerevisiae) -2.11175
RNF13 ring finger protein 13 -2.10127
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.08795
DDIT4 DNA-damage-inducible transcript 4 -2.08715
ITGB1BP1 integrin beta 1 binding protein 1 -2.07405
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.07165
HAUS2 HAUS augmin-like complex, subunit 2 -2.0681
CDCP1 CUB domain containing protein 1 -2.06705
TMBIM4 transmembrane BAX inhibitor motif containing 4 -2.0638
NLK nemo-like kinase -2.0558
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.0508
FAIM Fas apoptotic inhibitory molecule -2.04715
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 -2.03975
CCDC106 coiled-coil domain containing 106 -2.02635
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -2.0172