CRCGN011_HEPG2_24H:A06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

182 genes differentially expressed following the CRCGN011_HEPG2_24H:A06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 5.78135
PLS1 plastin 1 5.70465
UBQLN2 ubiquilin 2 4.97735
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.8973
E2F2 E2F transcription factor 2 4.87275
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.84555
PPARG peroxisome proliferator-activated receptor gamma 4.80155
ADGRE5 adhesion G protein-coupled receptor E5 4.6724
PNKP polynucleotide kinase 3'-phosphatase 4.4086
TLR4 toll-like receptor 4 4.3673
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.10995
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.90345
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.62105
NOSIP nitric oxide synthase interacting protein 3.61965
TIAM1 T-cell lymphoma invasion and metastasis 1 3.41657
ZDHHC6 zinc finger, DHHC-type containing 6 3.3832
IQGAP1 IQ motif containing GTPase activating protein 1 3.36012
SNAP25 synaptosomal-associated protein, 25kDa 3.3537
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 3.21965
RXYLT1 ribitol xylosyltransferase 1 3.16978
NNT nicotinamide nucleotide transhydrogenase 3.06865
MEST mesoderm specific transcript 2.93985
UBE3C ubiquitin protein ligase E3C 2.89245
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.81715
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.79313
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.779
PDLIM1 PDZ and LIM domain 1 2.7309
FASTKD5 FAST kinase domains 5 2.7089
BAD BCL2-associated agonist of cell death 2.7052
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.69222
DENND2D DENN/MADD domain containing 2D 2.6504
FOXB1 forkhead box B1 2.50825
CCNF cyclin F 2.50522
FNDC3B fibronectin type III domain containing 3B 2.4859
HMOX1 heme oxygenase 1 2.4342
PGRMC1 progesterone receptor membrane component 1 2.4271
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 2.4252
SQOR sulfide quinone oxidoreductase 2.41945
CCDC86 coiled-coil domain containing 86 2.406
CYFIP1 cytoplasmic FMR1 interacting protein 1 2.3923
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 2.3793
RHD Rh blood group, D antigen 2.3762
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.3594
DUSP14 dual specificity phosphatase 14 2.3506
POLR1A polymerase (RNA) I polypeptide A, 194kDa 2.3241
ANKRD10 ankyrin repeat domain 10 2.32295
ZBTB11 zinc finger and BTB domain containing 11 2.3154
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.30807
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.30405
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 2.2977
CADM4 cell adhesion molecule 4 2.29335
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.29295
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.29065
PRDM13 PR domain containing 13 2.2835
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.27765
TTC21B tetratricopeptide repeat domain 21B 2.27355
SIX6 SIX homeobox 6 2.2674
TXNL4B thioredoxin-like 4B 2.26595
ZNF155 zinc finger protein 155 2.263
EGLN1 egl-9 family hypoxia-inducible factor 1 2.2589
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2.24255
MED25 mediator complex subunit 25 2.2305
MTSS2 MTSS I-BAR domain containing 2 2.23035
ICE2 interactor of little elongation complex ELL subunit 2 2.22285
TXK TXK tyrosine kinase 2.21615
NISCH nischarin 2.2126
PHB1 prohibitin 1 2.20603
AFF3 AF4/FMR2 family, member 3 2.19763
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.1927
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 2.17865
BIRC2 baculoviral IAP repeat containing 2 2.17525
ZBTB7C zinc finger and BTB domain containing 7C 2.1668
DIRAS3 DIRAS family, GTP-binding RAS-like 3 2.1658
ALX4 ALX homeobox 4 2.1618
ASIC2 acid sensing (proton gated) ion channel 2 2.148
MORC3 MORC family CW-type zinc finger 3 2.1429
PHKB phosphorylase kinase, beta 2.1394
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.1384
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 2.1251
ASCL2 achaete-scute family bHLH transcription factor 2 2.1247
BIN2 bridging integrator 2 2.12395
AGTR2 angiotensin II receptor, type 2 2.11837
GAS2 growth arrest-specific 2 2.1147
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 2.1137
MTRF1L mitochondrial translational release factor 1-like 2.10975
POU4F1 POU class 4 homeobox 1 2.10745
OVGP1 oviductal glycoprotein 1, 120kDa 2.10595
ZNF37A zinc finger protein 37A 2.0993
SYTL3 synaptotagmin-like 3 2.08815
TMEM147 transmembrane protein 147 2.08265
TOP2A topoisomerase (DNA) II alpha 170kDa 2.08253
MBNL3 muscleblind-like splicing regulator 3 2.0776
LOC122526780 uncharacterized LOC122526780 2.07475
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 2.0724
ZMYM6 zinc finger, MYM-type 6 2.0664
CFAP46 cilia and flagella associated protein 46 2.06565
RAPSN receptor-associated protein of the synapse 2.0625
DNAI2 dynein, axonemal, intermediate chain 2 2.06157
AMELX amelogenin, X-linked 2.05825
CASC3 cancer susceptibility candidate 3 2.05385
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.05235
ACOXL acyl-CoA oxidase-like 2.05005
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.04945
BTK Bruton agammaglobulinemia tyrosine kinase 2.04935
PLA2R1 phospholipase A2 receptor 1, 180kDa 2.0413
FOXD2 forkhead box D2 2.03525
HOXA6 homeobox A6 2.03465
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.03335
SOCS6 suppressor of cytokine signaling 6 2.02575
DOT1L DOT1-like histone H3K79 methyltransferase 2.02525
ZNF407 zinc finger protein 407 2.02375
ATG3 autophagy related 3 2.02115
CHN1 chimerin 1 2.01985
PRPF31 pre-mRNA processing factor 31 2.01655
GRAMD1B GRAM domain containing 1B 2.0109
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.01035
KSR1 kinase suppressor of ras 1 2.00327
CRTAM cytotoxic and regulatory T cell molecule 2.00295
PHF24 PHD finger protein 24 2.0022
SCARB1 scavenger receptor class B, member 1 2.00208

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -5.77535
SCAND1 SCAN domain containing 1 -5.35045
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
ZW10 zw10 kinetochore protein -5.0
NR2F6 nuclear receptor subfamily 2, group F, member 6 -4.96302
LDHD lactate dehydrogenase D -4.94875
MRPS16 mitochondrial ribosomal protein S16 -4.8838
C2CD5 C2 calcium-dependent domain containing 5 -4.72115
CD320 CD320 molecule -4.7008
PRCP prolylcarboxypeptidase (angiotensinase C) -4.58995
NGRN neugrin, neurite outgrowth associated -4.1697
TM9SF2 transmembrane 9 superfamily member 2 -4.05345
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.5409
GNAS GNAS complex locus -3.45643
CHIC2 cysteine-rich hydrophobic domain 2 -3.41685
PCNA proliferating cell nuclear antigen -3.23445
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -3.1827
CIRBP cold inducible RNA binding protein -3.1735
CAB39 calcium binding protein 39 -2.9856
MTFR1 mitochondrial fission regulator 1 -2.9435
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.92765
TCEAL4 transcription elongation factor A (SII)-like 4 -2.92605
ITGB1BP1 integrin beta 1 binding protein 1 -2.90743
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.7639
MAPK13 mitogen-activated protein kinase 13 -2.69655
ENY2 enhancer of yellow 2 homolog (Drosophila) -2.69155
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.58155
GOLT1B golgi transport 1B -2.57915
DYNLT3 dynein, light chain, Tctex-type 3 -2.57185
GRWD1 glutamate-rich WD repeat containing 1 -2.57175
GDF15 growth differentiation factor 15 -2.5592
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.54275
TM9SF3 transmembrane 9 superfamily member 3 -2.52305
FOS FBJ murine osteosarcoma viral oncogene homolog -2.5133
FAIM Fas apoptotic inhibitory molecule -2.46335
LRRC41 leucine rich repeat containing 41 -2.45493
SLC35F2 solute carrier family 35, member F2 -2.42835
MOK MOK protein kinase -2.34455
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.33015
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) -2.3076
FPGS folylpolyglutamate synthase -2.3014
LOC112694756 uncharaterized LOC112694756 -2.28758
CPE carboxypeptidase E -2.2013
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -2.1997
ACLY ATP citrate lyase -2.1911
PRKX protein kinase, X-linked -2.1738
MTA1 metastasis associated 1 -2.17263
CTSD cathepsin D -2.16245
SCHIP1 schwannomin interacting protein 1 -2.14945
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.14705
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.1402
DDIT4 DNA-damage-inducible transcript 4 -2.1369
HAT1 histone acetyltransferase 1 -2.1265
VAT1 vesicle amine transport 1 -2.1135
HSPA1A heat shock 70kDa protein 1A -2.1002
SEC24C SEC24 family member C -2.07225
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.0694
RBKS ribokinase -2.05498
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.0291
KIF14 kinesin family member 14 -2.0239
SNRPF small nuclear ribonucleoprotein polypeptide F -2.01175
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.00285