CRCGN011_HEPG2_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description picloram, technical grade 41.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

120 genes differentially expressed following the CRCGN011_HEPG2_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 6.37245
TLR4 toll-like receptor 4 5.51455
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.178
CCL2 chemokine (C-C motif) ligand 2 4.92765
STIMATE STIM activating enhancer 4.7404
BACE2 beta-site APP-cleaving enzyme 2 4.7061
CAPN1 calpain 1, (mu/I) large subunit 4.5086
ADGRE5 adhesion G protein-coupled receptor E5 4.47225
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.35845
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.23355
CHMP6 charged multivesicular body protein 6 4.01005
NOSIP nitric oxide synthase interacting protein 3.87495
CYCS cytochrome c, somatic 3.661
TIAM1 T-cell lymphoma invasion and metastasis 1 3.15465
PLEKHJ1 pleckstrin homology domain containing, family J member 1 3.07645
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 2.79255
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.74435
NENF neudesin neurotrophic factor 2.66527
CTSL cathepsin L 2.63265
ZDHHC6 zinc finger, DHHC-type containing 6 2.60195
CREG1 cellular repressor of E1A-stimulated genes 1 2.5247
FASTKD5 FAST kinase domains 5 2.5186
AUH AU RNA binding protein/enoyl-CoA hydratase 2.49895
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.48315
TGFB3 transforming growth factor, beta 3 2.4542
MAGEA6 melanoma antigen family A6 2.4441
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.394
CCL8 chemokine (C-C motif) ligand 8 2.39235
DIPK1A divergent protein kinase domain 1A 2.38315
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.34635
KHDC4 KH domain containing 4, pre-mRNA splicing factor 2.3151
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.298
BAD BCL2-associated agonist of cell death 2.26905
TBXA2R thromboxane A2 receptor 2.24896
COMMD10 COMM domain containing 10 2.2466
MTERF3 mitochondrial transcription termination factor 3 2.2126
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.20285
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.1898
DEPDC5 DEP domain containing 5 2.16095
UBA3 ubiquitin-like modifier activating enzyme 3 2.15045
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2.1373
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 2.1069
IFI16 interferon, gamma-inducible protein 16 2.10133
CHEK2 checkpoint kinase 2 2.09917
GPATCH1 G patch domain containing 1 2.09255
GPR65 G protein-coupled receptor 65 2.0883
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.0881
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 2.08049
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.07475
SNX10 sorting nexin 10 2.06295
PRAME preferentially expressed antigen in melanoma 2.05475
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 2.0506
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.0424
TLR3 toll-like receptor 3 2.02635
FAM3C family with sequence similarity 3, member C 2.02605
RNF130 ring finger protein 130 2.0257
TXNRD1 thioredoxin reductase 1 2.0241
MOK MOK protein kinase 2.02375
CXCL11 chemokine (C-X-C motif) ligand 11 2.02355
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.02268
CD40 CD40 molecule, TNF receptor superfamily member 5 2.00795
BIN2 bridging integrator 2 2.00685

decreased expression

Symbol Name Standardized Value
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -8.97135
CCNB2 cyclin B2 -7.8324
TSEN2 TSEN2 tRNA splicing endonuclease subunit -6.1226
TCTN1 tectonic family member 1 -5.4086
ZW10 zw10 kinetochore protein -5.0393
NGRN neugrin, neurite outgrowth associated -4.5424
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.3958
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.8967
ZMIZ1 zinc finger, MIZ-type containing 1 -3.89485
KDM3A lysine (K)-specific demethylase 3A -3.75425
CHIC2 cysteine-rich hydrophobic domain 2 -3.73045
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.65495
FBXL12 F-box and leucine-rich repeat protein 12 -3.5295
CAB39 calcium binding protein 39 -3.2785
NT5DC2 5'-nucleotidase domain containing 2 -3.24605
MAPK13 mitogen-activated protein kinase 13 -3.1193
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.04225
TBC1D10C TBC1 domain family, member 10C -3.00875
HEATR1 HEAT repeat containing 1 -2.95465
RPS5 ribosomal protein S5 -2.8796
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.87147
REXO5 RNA exonuclease 5 -2.77647
SCAND1 SCAN domain containing 1 -2.6751
SLC35F2 solute carrier family 35, member F2 -2.64525
NPDC1 neural proliferation, differentiation and control, 1 -2.5856
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -2.57945
PEX11A peroxisomal biogenesis factor 11 alpha -2.50502
UNKL unkempt family zinc finger-like -2.44575
PECR peroxisomal trans-2-enoyl-CoA reductase -2.41715
CCDC85B coiled-coil domain containing 85B -2.37995
CTSD cathepsin D -2.37145
CRYGD crystallin, gamma D -2.3687
RASL11B RAS-like, family 11, member B -2.3661
ZNF586 zinc finger protein 586 -2.36235
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.3509
STN1 STN1 subunit of CST complex -2.29655
DRC4 dynein regulatory complex subunit 4 -2.2727
TOMM34 translocase of outer mitochondrial membrane 34 -2.27045
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 -2.2196
NUBPL nucleotide binding protein-like -2.2087
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -2.20425
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 -2.1816
ZBTB44 zinc finger and BTB domain containing 44 -2.1782
GRN granulin -2.16445
TWNK twinkle mtDNA helicase -2.11075
TCEAL4 transcription elongation factor A (SII)-like 4 -2.10475
APRT adenine phosphoribosyltransferase -2.09328
CDC20 cell division cycle 20 -2.07105
PHLDA2 pleckstrin homology-like domain, family A, member 2 -2.06305
S100A9 S100 calcium binding protein A9 -2.0624
RAB11FIP5 RAB11 family interacting protein 5 (class I) -2.05335
CEMIP cell migration inducing protein, hyaluronan binding -2.0528
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.04715
CLOCK clock circadian regulator -2.04595
EFNA3 ephrin-A3 -2.04195
COL2A1 collagen, type II, alpha 1 -2.0259
LOC112694756 uncharaterized LOC112694756 -2.02147
AHDC1 AT hook, DNA binding motif, containing 1 -2.0066