CRCGN011_HEPG2_24H:A10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description picloram, technical grade 5.13 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

79 genes differentially expressed following the CRCGN011_HEPG2_24H:A10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.99255
ZNF589 zinc finger protein 589 5.74068
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.68835
IDE insulin-degrading enzyme 4.45807
FCHO1 FCH domain only 1 4.3704
UBQLN2 ubiquilin 2 4.16275
MAP7 microtubule-associated protein 7 3.88008
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.87625
WDTC1 WD and tetratricopeptide repeats 1 3.58532
TLR4 toll-like receptor 4 3.54375
CHEK2 checkpoint kinase 2 3.18465
ACTMAP actin maturation protease 2.83765
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.74237
PGLYRP4 peptidoglycan recognition protein 4 2.74035
MEST mesoderm specific transcript 2.67545
TYR tyrosinase 2.62455
SMAD3 SMAD family member 3 2.57865
TSKU tsukushi, small leucine rich proteoglycan 2.55605
WASF3 WAS protein family, member 3 2.53485
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.514
MED24 mediator complex subunit 24 2.4337
COQ8A coenzyme Q8A 2.42375
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.3733
UBAC1 UBA domain containing 1 2.3405
ARMH3 armadillo like helical domain containing 3 2.26447
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.2587
NUP62CL nucleoporin 62kDa C-terminal like 2.20945
FASTKD5 FAST kinase domains 5 2.1813
MTERF3 mitochondrial transcription termination factor 3 2.1446
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 2.12775
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2.10073
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 2.0928
ENTREP1 endosomal transmembrane epsin interactor 1 2.0864
DNALI1 dynein, axonemal, light intermediate chain 1 2.07775
PARG poly (ADP-ribose) glycohydrolase 2.0745
DUS2 dihydrouridine synthase 2 2.0717
RMDN1 regulator of microtubule dynamics 1 2.0645
OR5I1 olfactory receptor, family 5, subfamily I, member 1 2.06335
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow 2.04615
SLCO4C1 solute carrier organic anion transporter family, member 4C1 2.03675
PTDSS1 phosphatidylserine synthase 1 2.03225
CPT1B carnitine palmitoyltransferase 1B (muscle) 2.02467
ZNF507 zinc finger protein 507 2.0223
CYCS cytochrome c, somatic 2.0186
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.01667
GPR143 G protein-coupled receptor 143 2.0026

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -7.26025
LDHD lactate dehydrogenase D -5.0842
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.50635
DNM1L dynamin 1-like -4.4939
CD320 CD320 molecule -4.09315
NVL nuclear VCP-like -3.7458
EIF5 eukaryotic translation initiation factor 5 -3.66095
PCNA proliferating cell nuclear antigen -3.6049
GNAS GNAS complex locus -3.48534
MACF1 microtubule-actin crosslinking factor 1 -3.04553
ITGB1BP1 integrin beta 1 binding protein 1 -2.9773
WASHC4 WASH complex subunit 4 -2.9704
NGRN neugrin, neurite outgrowth associated -2.82095
TLCD3A TLC domain containing 3A -2.78305
HEATR1 HEAT repeat containing 1 -2.48528
ACLY ATP citrate lyase -2.47798
SCG5 secretogranin V -2.44925
DDIT4 DNA-damage-inducible transcript 4 -2.4035
TSPAN13 tetraspanin 13 -2.3623
ZW10 zw10 kinetochore protein -2.26645
VAMP5 vesicle-associated membrane protein 5 -2.2497
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -2.216
SSR4 signal sequence receptor, delta -2.2128
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.18955
PHF11 PHD finger protein 11 -2.1562
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.08665
AKAP11 A kinase (PRKA) anchor protein 11 -2.06365
SQOR sulfide quinone oxidoreductase -2.0622
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A -2.0498
ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 -2.04105
MAK16 MAK16 homolog (S. cerevisiae) -2.0253
LPL lipoprotein lipase -2.0151
TBK1 TANK-binding kinase 1 -2.01435