CRCGN011_HEPG2_24H:A11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description picloram, technical grade 2.56 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

103 genes differentially expressed following the CRCGN011_HEPG2_24H:A11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLS1 plastin 1 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.9373
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 4.8408
SNAP25 synaptosomal-associated protein, 25kDa 4.66372
COQ8A coenzyme Q8A 4.54145
PPARG peroxisome proliferator-activated receptor gamma 4.4814
BZW2 basic leucine zipper and W2 domains 2 3.9867
KLHL9 kelch-like family member 9 3.38177
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa 3.35585
TIAM1 T-cell lymphoma invasion and metastasis 1 3.35575
UBQLN2 ubiquilin 2 3.31925
CHMP6 charged multivesicular body protein 6 3.20745
ATP11B ATPase, class VI, type 11B 3.14135
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 3.04385
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.8589
SLC38A10 solute carrier family 38, member 10 2.6681
CHN1 chimerin 1 2.6459
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 2.5824
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.5809
NT5DC2 5'-nucleotidase domain containing 2 2.52115
TREM1 triggering receptor expressed on myeloid cells 1 2.51365
CYCS cytochrome c, somatic 2.50545
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.4749
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.46685
LRRC59 leucine rich repeat containing 59 2.46295
MAST2 microtubule associated serine/threonine kinase 2 2.39237
CRELD2 cysteine-rich with EGF-like domains 2 2.3833
FOCAD focadhesin 2.30935
FNDC3B fibronectin type III domain containing 3B 2.28675
PARP2 poly (ADP-ribose) polymerase 2 2.22678
FASTKD5 FAST kinase domains 5 2.19665
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.1566
USP18 ubiquitin specific peptidase 18 2.1523
RNF167 ring finger protein 167 2.1284
PRR15L proline rich 15-like 2.10425
NR1H2 nuclear receptor subfamily 1, group H, member 2 2.0829
REG1B regenerating islet-derived 1 beta 2.05905
REG1A regenerating islet-derived 1 alpha 2.0461
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 2.03475
GEMIN4 gem (nuclear organelle) associated protein 4 2.02763
ADGRE5 adhesion G protein-coupled receptor E5 2.0199
HOOK2 hook microtubule-tethering protein 2 2.00455

decreased expression

Symbol Name Standardized Value
ZW10 zw10 kinetochore protein -6.69465
VAT1 vesicle amine transport 1 -5.84935
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.772
RPIA ribose 5-phosphate isomerase A -5.0451
ARID5B AT rich interactive domain 5B (MRF1-like) -4.9636
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.6163
FGFR4 fibroblast growth factor receptor 4 -4.20312
RALA v-ral simian leukemia viral oncogene homolog A (ras related) -4.0396
FAIM Fas apoptotic inhibitory molecule -3.99075
ACAA1 acetyl-CoA acyltransferase 1 -3.847
GNAS GNAS complex locus -3.53179
LRRC41 leucine rich repeat containing 41 -3.3252
HEATR1 HEAT repeat containing 1 -3.04273
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -3.04195
OXA1L oxidase (cytochrome c) assembly 1-like -2.93495
ZNF764 zinc finger protein 764 -2.7822
SQOR sulfide quinone oxidoreductase -2.7371
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.65455
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.53212
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.51325
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 -2.46835
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.45795
BRAF B-Raf proto-oncogene, serine/threonine kinase -2.38745
RBM15B RNA binding motif protein 15B -2.37995
YAF2 YY1 associated factor 2 -2.3697
FZD6 frizzled class receptor 6 -2.3581
ZMYM1 zinc finger, MYM-type 1 -2.3472
SLC35F2 solute carrier family 35, member F2 -2.3043
HSPA4 heat shock 70kDa protein 4 -2.29976
CPB2 carboxypeptidase B2 (plasma) -2.2733
GOLT1B golgi transport 1B -2.2526
ZNF586 zinc finger protein 586 -2.2458
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -2.24345
FGF4 fibroblast growth factor 4 -2.2379
CORO2A coronin, actin binding protein, 2A -2.2206
AKR1C1 aldo-keto reductase family 1, member C1 -2.19771
MBL2 mannose-binding lectin (protein C) 2, soluble -2.1934
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.1854
HPD 4-hydroxyphenylpyruvate dioxygenase -2.16825
ECEL1 endothelin converting enzyme-like 1 -2.1575
CRHBP corticotropin releasing hormone binding protein -2.14985
APOH apolipoprotein H (beta-2-glycoprotein I) -2.13935
MAT1A methionine adenosyltransferase I, alpha -2.1358
AAR2 AAR2 splicing factor homolog (S. cerevisiae) -2.13215
MBD5 methyl-CpG binding domain protein 5 -2.12445
MRPL18 mitochondrial ribosomal protein L18 -2.12275
HPX hemopexin -2.11473
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.10493
PUS3 pseudouridylate synthase 3 -2.08555
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa -2.08165
PTCD2 pentatricopeptide repeat domain 2 -2.0781
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -2.07735
AHSG alpha-2-HS-glycoprotein -2.06572
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.03955
PRDX1 peroxiredoxin 1 -2.034
DLAT dihydrolipoamide S-acetyltransferase -2.0333
HACD3 3-hydroxyacyl-CoA dehydratase 3 -2.03035
CRYGB crystallin, gamma B -2.02575
COL6A3 collagen, type VI, alpha 3 -2.02405
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.0144
F9 coagulation factor IX -2.0123