CRCGN011_HEPG2_24H:A14 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description m-phenylenediamine.2hcl 20.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN011_HEPG2_24H:A14 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PRR15L proline rich 15-like 6.3265
STIMATE STIM activating enhancer 5.6328
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.39385
MINDY1 MINDY lysine 48 deubiquitinase 1 5.0246
CARMIL1 capping protein regulator and myosin 1 linker 1 5.01205
CIAO3 cytosolic iron-sulfur assembly component 3 4.96155
CCL2 chemokine (C-C motif) ligand 2 4.61995
PEX11A peroxisomal biogenesis factor 11 alpha 3.67658
ARPP19 cAMP-regulated phosphoprotein, 19kDa 3.26707
PMM2 phosphomannomutase 2 3.12925
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.97465
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.83105
CHN1 chimerin 1 2.74515
ADAT1 adenosine deaminase, tRNA-specific 1 2.41275
SNX7 sorting nexin 7 2.3421
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit 2.33375
COL11A1 collagen, type XI, alpha 1 2.30925
NFATC2IP nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein 2.24231
ZNF512B zinc finger protein 512B 2.2403
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.1425
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) 2.08695
MXRA5 matrix-remodelling associated 5 2.0078

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -10.0
PCCB propionyl CoA carboxylase, beta polypeptide -5.3682
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -4.87105
NT5DC2 5'-nucleotidase domain containing 2 -4.68825
VAT1 vesicle amine transport 1 -4.3249
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.2953
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -4.02657
HMG20B high mobility group 20B -3.94123
YME1L1 YME1-like 1 ATPase -3.9051
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.6247
PCNA proliferating cell nuclear antigen -3.52065
EXT1 exostosin glycosyltransferase 1 -3.18147
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.73892
HLA-DMA major histocompatibility complex, class II, DM alpha -2.56185
CD58 CD58 molecule -2.44198
NGRN neugrin, neurite outgrowth associated -2.42205
GAN gigaxonin -2.248
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 -2.19205
ITGB1BP1 integrin beta 1 binding protein 1 -2.16418
DAZAP1 DAZ associated protein 1 -2.1545
CUTA cutA divalent cation tolerance homolog (E. coli) -2.1161
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -2.0795
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.0768
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 -2.06205
EREG epiregulin -2.04305
WNT10B wingless-type MMTV integration site family, member 10B -2.0276
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) -2.02012
AFF4 AF4/FMR2 family, member 4 -2.0195
TXNIP thioredoxin interacting protein -2.01687
RFPL2 ret finger protein-like 2 -2.01685
CNGB3 cyclic nucleotide gated channel beta 3 -2.01355
STARD5 StAR-related lipid transfer (START) domain containing 5 -2.01045