CRCGN011_HEPG2_24H:A15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description m-phenylenediamine.2hcl 10.0 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

49 genes differentially expressed following the CRCGN011_HEPG2_24H:A15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 9.59905
NOTCH1 notch 1 5.41
MAMLD1 mastermind-like domain containing 1 4.85375
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.8284
CARMIL1 capping protein regulator and myosin 1 linker 1 4.74675
SNAP25 synaptosomal-associated protein, 25kDa 4.58333
UBQLN2 ubiquilin 2 4.58035
CXCR4 chemokine (C-X-C motif) receptor 4 4.34338
DENND2D DENN/MADD domain containing 2D 3.60355
EPN2 epsin 2 3.59262
FZD7 frizzled class receptor 7 3.51867
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.16693
LOC122526780 uncharacterized LOC122526780 3.13715
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.11655
TIAM1 T-cell lymphoma invasion and metastasis 1 3.01518
CEP57 centrosomal protein 57kDa 2.99026
DMTF1 cyclin D binding myb-like transcription factor 1 2.97463
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.81555
ADGRE5 adhesion G protein-coupled receptor E5 2.7997
JADE2 jade family PHD finger 2 2.6827
VGLL4 vestigial-like family member 4 2.64535
CDPF1 cysteine-rich, DPF motif domain containing 1 2.59445
ADAT1 adenosine deaminase, tRNA-specific 1 2.50255
PDE4B phosphodiesterase 4B, cAMP-specific 2.42272
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 2.35835
TCEA2 transcription elongation factor A (SII), 2 2.33395
ADGRG1 adhesion G protein-coupled receptor G1 2.29835
DYNLT3 dynein, light chain, Tctex-type 3 2.2757
TXLNA taxilin alpha 2.27455
MTERF3 mitochondrial transcription termination factor 3 2.25145
TTC23 tetratricopeptide repeat domain 23 2.22955
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.20748
GPER1 G protein-coupled estrogen receptor 1 2.1934
POMZP3 POM121 and ZP3 fusion 2.01005
CASD1 CAS1 domain containing 1 2.00645

decreased expression

Symbol Name Standardized Value
PRCP prolylcarboxypeptidase (angiotensinase C) -5.6266
KDM3A lysine (K)-specific demethylase 3A -5.4806
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.8192
THAP11 THAP domain containing 11 -4.74995
ZW10 zw10 kinetochore protein -4.70315
CHMP4B charged multivesicular body protein 4B -4.5128
MAPK13 mitogen-activated protein kinase 13 -4.18255
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.10035
GNAS GNAS complex locus -3.45871
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -2.69365
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.3765
ACP6 acid phosphatase 6, lysophosphatidic -2.35485
LGMN legumain -2.1723
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.15165