CRCGN011_HEPG2_24H:A17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description m-phenylenediamine.2hcl 2.5 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN011_HEPG2_24H:A17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.5075
JADE2 jade family PHD finger 2 5.40605
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.14055
NOTCH1 notch 1 5.1125
C2CD2 C2 calcium-dependent domain containing 2 5.0464
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.01065
RPP38 ribonuclease P/MRP 38kDa subunit 4.9248
STK10 serine/threonine kinase 10 4.27418
MAP7 microtubule-associated protein 7 3.6285
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 3.3547
CHEK2 checkpoint kinase 2 2.61495
GSTZ1 glutathione S-transferase zeta 1 2.3924
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.3427
EVL Enah/Vasp-like 2.1984
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.079

decreased expression

Symbol Name Standardized Value
VAT1 vesicle amine transport 1 -5.38345
NT5DC2 5'-nucleotidase domain containing 2 -5.04915
CD320 CD320 molecule -5.0
ZNF586 zinc finger protein 586 -4.7915
CDC20 cell division cycle 20 -4.2155
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.8067
GNAS GNAS complex locus -3.32743
CCNB2 cyclin B2 -3.1266
SLC35F2 solute carrier family 35, member F2 -2.52765
ITGA10 integrin, alpha 10 -2.3839
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.2649
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.2556
ITGB1BP1 integrin beta 1 binding protein 1 -2.22605
CPNE7 copine VII -2.19545
ZNF134 zinc finger protein 134 -2.17335
CAPRIN1 cell cycle associated protein 1 -2.16178
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) -2.0905
TTLL1 tubulin tyrosine ligase-like family member 1 -2.08675