CRCGN011_HEPG2_24H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN011_HEPG2_24H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.1208
RPP38 ribonuclease P/MRP 38kDa subunit 4.9335
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.67165
TLR4 toll-like receptor 4 4.63385
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.96665
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.77395
WDTC1 WD and tetratricopeptide repeats 1 3.28363
CYCS cytochrome c, somatic 3.10125
TREM1 triggering receptor expressed on myeloid cells 1 2.95905
CGRRF1 cell growth regulator with ring finger domain 1 2.92535
PARP2 poly (ADP-ribose) polymerase 2 2.79828
CDC45 cell division cycle 45 2.70095
ERLIN1 ER lipid raft associated 1 2.3724
PIH1D1 PIH1 domain containing 1 2.3335
OXSM 3-oxoacyl-ACP synthase, mitochondrial 2.19505
RNF167 ring finger protein 167 2.1269
KLHL9 kelch-like family member 9 2.097
CHN1 chimerin 1 2.07995
CLUH clustered mitochondria (cluA/CLU1) homolog 2.0522
MTERF3 mitochondrial transcription termination factor 3 2.02955
ACADVL acyl-CoA dehydrogenase, very long chain 2.01125

decreased expression

Symbol Name Standardized Value
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -5.796
PECR peroxisomal trans-2-enoyl-CoA reductase -5.6239
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.06905
RPS4Y1 ribosomal protein S4, Y-linked 1 -5.0
MAPK13 mitogen-activated protein kinase 13 -3.8073
GRWD1 glutamate-rich WD repeat containing 1 -3.6544
CTSD cathepsin D -3.49995
CDC25B cell division cycle 25B -3.32155
GNAS GNAS complex locus -3.16689
FABP5 fatty acid binding protein 5 (psoriasis-associated) -3.09155
TRAP1 TNF receptor-associated protein 1 -2.99975
COG7 component of oligomeric golgi complex 7 -2.98005
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.97547
CCNB2 cyclin B2 -2.92835
TBCB tubulin folding cofactor B -2.87797
GPATCH1 G patch domain containing 1 -2.5964
ZNF586 zinc finger protein 586 -2.54135
ITGB1BP1 integrin beta 1 binding protein 1 -2.4506
SLC35F2 solute carrier family 35, member F2 -2.354
C5 complement component 5 -2.29535
DERA deoxyribose-phosphate aldolase (putative) -2.26955
SNX11 sorting nexin 11 -2.22925
NELL2 NEL-like 2 (chicken) -2.1094
NOTCH1 notch 1 -2.1048
S100A4 S100 calcium binding protein A4 -2.03045
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.0097