CRCGN011_HEPG2_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

100 genes differentially expressed following the CRCGN011_HEPG2_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 8.74785
PNKP polynucleotide kinase 3'-phosphatase 5.4219
CHMP6 charged multivesicular body protein 6 5.19885
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 5.10845
CCDC92 coiled-coil domain containing 92 5.0
UBQLN2 ubiquilin 2 4.36105
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.31555
GPER1 G protein-coupled estrogen receptor 1 3.8902
ATP11B ATPase, class VI, type 11B 3.86765
NMU neuromedin U 3.7834
SNAP25 synaptosomal-associated protein, 25kDa 3.59275
PRR15L proline rich 15-like 3.53235
TIAM1 T-cell lymphoma invasion and metastasis 1 3.46173
TLR4 toll-like receptor 4 3.30935
MAGEA6 melanoma antigen family A6 3.22543
ADGRE5 adhesion G protein-coupled receptor E5 3.11235
MUC6 mucin 6, oligomeric mucus/gel-forming 3.00055
RXYLT1 ribitol xylosyltransferase 1 3.00025
KIFAP3 kinesin-associated protein 3 2.78865
PLSCR3 phospholipid scramblase 3 2.76275
SOCS2 suppressor of cytokine signaling 2 2.6822
LRRC47 leucine rich repeat containing 47 2.6704
PCDHB11 protocadherin beta 11 2.62054
SLIT2 slit homolog 2 (Drosophila) 2.5746
EPHA3 EPH receptor A3 2.54362
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.54268
CRYGD crystallin, gamma D 2.5273
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.50733
CCNF cyclin F 2.50725
KDM1A lysine (K)-specific demethylase 1A 2.47845
NPTX2 neuronal pentraxin II 2.42135
SARS1 seryl-tRNA synthetase 1 2.3789
RPL3L ribosomal protein L3-like 2.3624
SHISAL1 shisa like 1 2.32377
ZNF365 zinc finger protein 365 2.3167
CTRC chymotrypsin C (caldecrin) 2.29665
MAT1A methionine adenosyltransferase I, alpha 2.28935
NOL9 nucleolar protein 9 2.2856
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.2795
MAP3K6 mitogen-activated protein kinase kinase kinase 6 2.27505
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.2682
KCNQ4 potassium channel, voltage gated KQT-like subfamily Q, member 4 2.2664
ECI2 enoyl-CoA delta isomerase 2 2.26385
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.25905
IL3 interleukin 3 2.2481
CMA1 chymase 1, mast cell 2.23115
IQSEC1 IQ motif and Sec7 domain 1 2.2304
ACKR5 atypical chemokine receptor 5 2.2241
HRC histidine rich calcium binding protein 2.20875
ICAM5 intercellular adhesion molecule 5, telencephalin 2.203
ELAC2 elaC ribonuclease Z 2 2.1814
SKIC2 SKI2 subunit of superkiller complex 2.17115
PACRG PARK2 co-regulated 2.15382
NOP53 NOP53 ribosome biogenesis factor 2.13885
ERO1B endoplasmic reticulum oxidoreductase 1 beta 2.13645
ZNF324B zinc finger protein 324B 2.13145
CASD1 CAS1 domain containing 1 2.12715
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.1269
HLA-DOB major histocompatibility complex, class II, DO beta 2.12255
SCTR secretin receptor 2.1065
PARK7 parkinson protein 7 2.1049
TROAP trophinin associated protein 2.10305
GRID2 glutamate receptor, ionotropic, delta 2 2.0832
HOXC8 homeobox C8 2.07025
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.06935
HOXC10 homeobox C10 2.0683
TRAPPC8 trafficking protein particle complex 8 2.0364
TNNI3 troponin I type 3 (cardiac) 2.02798
LEMD3 LEM domain containing 3 2.02295
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 2.0216
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.00455

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -8.3537
KDM3A lysine (K)-specific demethylase 3A -6.1224
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -5.81875
CCNB1 cyclin B1 -5.20735
ZDHHC6 zinc finger, DHHC-type containing 6 -5.16965
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.0
MAP7 microtubule-associated protein 7 -4.74853
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.5537
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.2178
HMG20B high mobility group 20B -3.8372
DERA deoxyribose-phosphate aldolase (putative) -3.35125
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.14283
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.08382
CDC25B cell division cycle 25B -2.8564
NPDC1 neural proliferation, differentiation and control, 1 -2.7729
NRIP1 nuclear receptor interacting protein 1 -2.57035
OXA1L oxidase (cytochrome c) assembly 1-like -2.4094
EIF5 eukaryotic translation initiation factor 5 -2.39878
FOS FBJ murine osteosarcoma viral oncogene homolog -2.3779
CCNB2 cyclin B2 -2.28375
PAQR6 progestin and adipoQ receptor family member VI -2.22245
TRAF5 TNF receptor-associated factor 5 -2.22195
GOLPH3 golgi phosphoprotein 3 (coat-protein) -2.1603
KRT20 keratin 20, type I -2.12725
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -2.1221
HSPA14 heat shock 70kDa protein 14 -2.068
BUD31 BUD31 homolog (S. cerevisiae) -2.0415
TMEM126B transmembrane protein 126B -2.03035
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.00053