CRCGN011_HEPG2_24H:A22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 4.97 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

80 genes differentially expressed following the CRCGN011_HEPG2_24H:A22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 10.0
MYLK myosin light chain kinase 5.7575
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.01635
LCN2 lipocalin 2 5.0
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 4.8579
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 4.79875
SQOR sulfide quinone oxidoreductase 4.6667
TIAM1 T-cell lymphoma invasion and metastasis 1 4.25413
STK10 serine/threonine kinase 10 3.9541
STIMATE STIM activating enhancer 3.6791
ATP11B ATPase, class VI, type 11B 3.5455
SSBP2 single-stranded DNA binding protein 2 3.4674
KIF5C kinesin family member 5C 2.97808
GPATCH8 G patch domain containing 8 2.95515
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.85315
PFKL phosphofructokinase, liver 2.8461
PTPN6 protein tyrosine phosphatase, non-receptor type 6 2.83705
PILRB paired immunoglobin-like type 2 receptor beta 2.57325
SOCS2 suppressor of cytokine signaling 2 2.54222
TTK TTK protein kinase 2.468
HOOK2 hook microtubule-tethering protein 2 2.42372
BAX BCL2-associated X protein 2.4062
FASTKD5 FAST kinase domains 5 2.3095
CHEK2 checkpoint kinase 2 2.2805
GBE1 glucan (1,4-alpha-), branching enzyme 1 2.2605
DOCK2 dedicator of cytokinesis 2 2.2438
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.23745
SYNE2 spectrin repeat containing, nuclear envelope 2 2.20165
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.18408
HMG20A high mobility group 20A 2.12805
SAP25 Sin3A-associated protein, 25kDa 2.12538
UBXN8 UBX domain protein 8 2.047
GCA grancalcin, EF-hand calcium binding protein 2.03045
PRR15L proline rich 15-like 2.023
WDR43 WD repeat domain 43 2.01205
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.01172

decreased expression

Symbol Name Standardized Value
GNAS GNAS complex locus -7.38039
LAP3 leucine aminopeptidase 3 -5.70265
CCNB1 cyclin B1 -5.26805
PLK1 polo-like kinase 1 -5.02065
C2CD5 C2 calcium-dependent domain containing 5 -4.94
TUBB6 tubulin, beta 6 class V -4.6916
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.6528
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.52715
CHMP4B charged multivesicular body protein 4B -4.01702
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.63055
LOC124907782 dual specificity protein phosphatase 22 -3.21215
CHIC2 cysteine-rich hydrophobic domain 2 -3.1564
TLCD3A TLC domain containing 3A -2.9334
DERA deoxyribose-phosphate aldolase (putative) -2.8727
OXA1L oxidase (cytochrome c) assembly 1-like -2.827
GRWD1 glutamate-rich WD repeat containing 1 -2.78245
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -2.76915
RDH16 retinol dehydrogenase 16 (all-trans) -2.4891
PABPC3 poly(A) binding protein, cytoplasmic 3 -2.44925
NPDC1 neural proliferation, differentiation and control, 1 -2.377
NEUROD6 neuronal differentiation 6 -2.289
COXFA4 cytochrome c oxidase associated subunit FA4 -2.2562
AMZ2 archaelysin family metallopeptidase 2 -2.25185
RFC2 replication factor C (activator 1) 2, 40kDa -2.23782
AARS1 alanyl-tRNA synthetase 1 -2.23095
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.2139
RLIM ring finger protein, LIM domain interacting -2.2092
LHX6 LIM homeobox 6 -2.20855
PZP pregnancy-zone protein -2.19055
GYS2 glycogen synthase 2 (liver) -2.17995
REEP5 receptor accessory protein 5 -2.14377
CETP cholesteryl ester transfer protein, plasma -2.1205
ASPN asporin -2.10855
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 -2.08565
DUSP21 dual specificity phosphatase 21 -2.0831
CXXC4 CXXC finger protein 4 -2.07885
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.06335
SHTN1 shootin 1 -2.0603
CSF1R colony stimulating factor 1 receptor -2.05935
IQSEC2 IQ motif and Sec7 domain 2 -2.05545
HGFAC HGF activator -2.05175
RMDN3 regulator of microtubule dynamics 3 -2.04525
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 -2.0405
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.01655