CRCGN011_HEPG2_24H:A23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 2.49 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

106 genes differentially expressed following the CRCGN011_HEPG2_24H:A23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STIMATE STIM activating enhancer 8.55755
CYCS cytochrome c, somatic 5.31175
CARMIL1 capping protein regulator and myosin 1 linker 1 5.1145
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.06175
PPARG peroxisome proliferator-activated receptor gamma 4.9083
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.84705
CCNA1 cyclin A1 4.77435
EPHB2 EPH receptor B2 4.75244
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.67915
HEBP1 heme binding protein 1 4.1956
PLSCR1 phospholipid scramblase 1 3.6593
AMDHD2 amidohydrolase domain containing 2 3.6164
CCL2 chemokine (C-C motif) ligand 2 3.2365
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 3.1405
NSDHL NAD(P) dependent steroid dehydrogenase-like 3.0364
SSBP2 single-stranded DNA binding protein 2 2.9997
DYNLT3 dynein, light chain, Tctex-type 3 2.92945
SPRED2 sprouty-related, EVH1 domain containing 2 2.81325
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 2.79685
GPER1 G protein-coupled estrogen receptor 1 2.79262
CISD1 CDGSH iron sulfur domain 1 2.76405
JADE2 jade family PHD finger 2 2.6349
TBXA2R thromboxane A2 receptor 2.61855
MT1E metallothionein 1E 2.5113
RSAD2 radical S-adenosyl methionine domain containing 2 2.47995
COL11A1 collagen, type XI, alpha 1 2.46613
VRK1 vaccinia related kinase 1 2.40045
MAGEA6 melanoma antigen family A6 2.36827
ANKRD46 ankyrin repeat domain 46 2.324
RUNDC3B RUN domain containing 3B 2.3071
ADAT1 adenosine deaminase, tRNA-specific 1 2.30175
MRAS muscle RAS oncogene homolog 2.29625
MT1H metallothionein 1H 2.2929
MATN4 matrilin 4 2.29045
ISG15 ISG15 ubiquitin-like modifier 2.28505
SPTAN1 spectrin, alpha, non-erythrocytic 1 2.27772
WASF3 WAS protein family, member 3 2.2772
EBF2 early B-cell factor 2 2.27135
CCDC92 coiled-coil domain containing 92 2.2586
MT1F metallothionein 1F 2.257
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.25229
VDAC2 voltage-dependent anion channel 2 2.23752
MPC1 mitochondrial pyruvate carrier 1 2.2168
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 2.20175
MUC4 mucin 4, cell surface associated 2.1956
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.1906
FASTKD5 FAST kinase domains 5 2.1693
DIPK1A divergent protein kinase domain 1A 2.16805
USP18 ubiquitin specific peptidase 18 2.1632
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.15123
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 2.1424
BIRC2 baculoviral IAP repeat containing 2 2.1372
NUP85 nucleoporin 85kDa 2.1357
FBXO17 F-box protein 17 2.12595
CTXND1 cortexin domain containing 1 2.1239
CHEK2 checkpoint kinase 2 2.1207
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 2.118
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.1119
PTCD1 pentatricopeptide repeat domain 1 2.0985
LCN2 lipocalin 2 2.0663
MMP10 matrix metallopeptidase 10 2.059
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.0558
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.0439
IFI44L interferon-induced protein 44-like 2.03605
HTN3 histatin 3 2.02845
IFNB1 interferon, beta 1, fibroblast 2.02305
SULT4A1 sulfotransferase family 4A, member 1 2.01935
DHDDS dehydrodolichyl diphosphate synthase 2.0146
MX1 MX dynamin-like GTPase 1 2.00025

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -8.33415
ZNF586 zinc finger protein 586 -6.7221
KDM3A lysine (K)-specific demethylase 3A -6.0608
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.39405
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -5.20435
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.86735
C2CD5 C2 calcium-dependent domain containing 5 -4.60855
MAPK13 mitogen-activated protein kinase 13 -4.13662
PCNA proliferating cell nuclear antigen -4.0817
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.5333
HEATR1 HEAT repeat containing 1 -3.52635
TWF2 twinfilin actin binding protein 2 -3.50995
WASHC4 WASH complex subunit 4 -3.48782
FGFR4 fibroblast growth factor receptor 4 -3.4089
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.26207
AZGP1 alpha-2-glycoprotein 1, zinc-binding -3.2383
NVL nuclear VCP-like -3.1535
NRIP1 nuclear receptor interacting protein 1 -3.06667
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.48395
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -2.46395
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.4463
ZNF134 zinc finger protein 134 -2.4357
ZNF26 zinc finger protein 26 -2.28055
RNF167 ring finger protein 167 -2.275
ZNF544 zinc finger protein 544 -2.2706
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.22155
PLS3 plastin 3 -2.20105
ZNF274 zinc finger protein 274 -2.19495
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.17585
UBE2M ubiquitin-conjugating enzyme E2M -2.15725
ZNF587B zinc finger protein 587B -2.10465
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) -2.0828
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.05588
ZNF227 zinc finger protein 227 -2.0238
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -2.0207
ZNF665 zinc finger protein 665 -2.0207
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa -2.01575