CRCGN011_HEPG2_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description phthalic anhydride 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

61 genes differentially expressed following the CRCGN011_HEPG2_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.6641
MYLK myosin light chain kinase 5.47235
MSRA methionine sulfoxide reductase A 5.2249
LCN2 lipocalin 2 5.0
INTS3 integrator complex subunit 3 4.6424
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.2849
RRAGA Ras-related GTP binding A 4.1526
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.9858
LOC122526780 uncharacterized LOC122526780 3.58945
JADE2 jade family PHD finger 2 3.27478
CCNF cyclin F 2.81932
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.74075
KIF5C kinesin family member 5C 2.67763
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.56005
CHEK2 checkpoint kinase 2 2.40587
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.31305
ENOPH1 enolase-phosphatase 1 2.30295
SDF2L1 stromal cell-derived factor 2-like 1 2.1891
DES desmin 2.1707
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.154
IQGAP1 IQ motif containing GTPase activating protein 1 2.08962
COL11A1 collagen, type XI, alpha 1 2.0817
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.0627
DIPK1A divergent protein kinase domain 1A 2.05207
TNIP1 TNFAIP3 interacting protein 1 2.0314
HPD 4-hydroxyphenylpyruvate dioxygenase 2.0302

decreased expression

Symbol Name Standardized Value
NT5DC2 5'-nucleotidase domain containing 2 -5.78745
KDM3A lysine (K)-specific demethylase 3A -5.2692
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.17705
GDF15 growth differentiation factor 15 -5.0
MRPS2 mitochondrial ribosomal protein S2 -4.9497
TRIB3 tribbles pseudokinase 3 -4.92435
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.84545
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
LDHD lactate dehydrogenase D -4.3978
CD58 CD58 molecule -4.00862
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.0051
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.3478
GNAS GNAS complex locus -2.95331
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.7918
ACLY ATP citrate lyase -2.592
CDC42 cell division cycle 42 -2.50129
FASTKD5 FAST kinase domains 5 -2.498
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.40965
MAB21L1 mab-21-like 1 (C. elegans) -2.3546
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) -2.32305
CCDC85B coiled-coil domain containing 85B -2.27625
AZGP1 alpha-2-glycoprotein 1, zinc-binding -2.26217
RLF rearranged L-myc fusion -2.2472
SLC35F2 solute carrier family 35, member F2 -2.20375
ZSCAN16 zinc finger and SCAN domain containing 16 -2.17255
RBM15B RNA binding motif protein 15B -2.16115
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -2.11805
NGRN neugrin, neurite outgrowth associated -2.11015
CPNE3 copine III -2.10052
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.0897
ERCC4 excision repair cross-complementation group 4 -2.08425
CTSD cathepsin D -2.07885
PF4 platelet factor 4 -2.0621
MCM3 minichromosome maintenance complex component 3 -2.03235
GEMIN8 gem (nuclear organelle) associated protein 8 -2.02055