CRCGN011_HEPG2_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

56 genes differentially expressed following the CRCGN011_HEPG2_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CHMP6 charged multivesicular body protein 6 8.52575
CSK c-src tyrosine kinase 5.08485
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 5.0488
CBR3 carbonyl reductase 3 4.94835
ADRB2 adrenoceptor beta 2, surface 4.7057
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 4.65415
ATP11B ATPase, class VI, type 11B 3.9761
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.78783
SNAP25 synaptosomal-associated protein, 25kDa 3.66613
SSBP2 single-stranded DNA binding protein 2 3.54748
LOC122526780 uncharacterized LOC122526780 3.46715
KHDC4 KH domain containing 4, pre-mRNA splicing factor 3.06365
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 3.04975
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 3.045
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.03903
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 3.03702
JADE2 jade family PHD finger 2 2.87213
FASTKD5 FAST kinase domains 5 2.8379
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 2.7738
GPATCH8 G patch domain containing 8 2.75102
CEP57 centrosomal protein 57kDa 2.62506
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.57785
HMOX1 heme oxygenase 1 2.4433
PLS1 plastin 1 2.3844
MAGEA10 melanoma antigen family A10 2.367
ELF2 E74-like factor 2 (ets domain transcription factor) 2.32547
CYCS cytochrome c, somatic 2.32545
AUH AU RNA binding protein/enoyl-CoA hydratase 2.3119
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing 2.1919
ZDHHC24 zinc finger, DHHC-type containing 24 2.16525
PCCB propionyl CoA carboxylase, beta polypeptide 2.159
HMGA2 high mobility group AT-hook 2 2.14575
TBC1D13 TBC1 domain family, member 13 2.12675
DPYD dihydropyrimidine dehydrogenase 2.1249
TYRP1 tyrosinase-related protein 1 2.1178
OCA2 oculocutaneous albinism II 2.08385
LY75-CD302 LY75-CD302 readthrough 2.07235
N4BP2L1 NEDD4 binding protein 2-like 1 2.03502

decreased expression

Symbol Name Standardized Value
UGDH UDP-glucose 6-dehydrogenase -5.5378
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.89945
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -4.2629
ADI1 acireductone dioxygenase 1 -3.79415
GRWD1 glutamate-rich WD repeat containing 1 -3.78385
MAPK13 mitogen-activated protein kinase 13 -3.48782
TLCD3A TLC domain containing 3A -3.4563
YME1L1 YME1-like 1 ATPase -3.28295
CD58 CD58 molecule -3.19117
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -3.16675
HMG20B high mobility group 20B -2.964
PCNA proliferating cell nuclear antigen -2.95295
NRIP1 nuclear receptor interacting protein 1 -2.80775
RNF167 ring finger protein 167 -2.60695
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.38425
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.34798
MNT MAX network transcriptional repressor -2.1872
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -2.0098