CRCGN011_HEPG2_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 39.8 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

335 genes differentially expressed following the CRCGN011_HEPG2_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CYCS cytochrome c, somatic 5.86995
CAPN1 calpain 1, (mu/I) large subunit 5.8642
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) 5.65875
MOK MOK protein kinase 5.5193
SYNGR3 synaptogyrin 3 5.40475
EPHB2 EPH receptor B2 5.39022
RSU1 Ras suppressor protein 1 5.35505
TLR4 toll-like receptor 4 5.30355
NMU neuromedin U 5.2418
CHMP6 charged multivesicular body protein 6 5.145
CSK c-src tyrosine kinase 5.08485
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 5.03285
CBR1 carbonyl reductase 1 5.01025
LCN2 lipocalin 2 5.0
BACE2 beta-site APP-cleaving enzyme 2 4.89505
TXNRD1 thioredoxin reductase 1 4.81875
PRKCD protein kinase C, delta 4.75715
HEBP1 heme binding protein 1 4.6942
CIAO3 cytosolic iron-sulfur assembly component 3 4.58395
AMDHD2 amidohydrolase domain containing 2 4.4308
MYLK myosin light chain kinase 4.3516
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.1387
SOX2 SRY (sex determining region Y)-box 2 4.0475
MUC1 mucin 1, cell surface associated 4.00425
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 3.94725
SNAP25 synaptosomal-associated protein, 25kDa 3.89003
NNT nicotinamide nucleotide transhydrogenase 3.83595
CRTAP cartilage associated protein 3.6923
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.52105
FCHO1 FCH domain only 1 3.48795
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 3.464
CCNF cyclin F 3.39925
MICALL1 MICAL-like 1 3.37108
KLHL9 kelch-like family member 9 3.32503
SH3D19 SH3 domain containing 19 3.319
RNF43 ring finger protein 43 3.2435
PPIE peptidylprolyl isomerase E (cyclophilin E) 3.23333
OXCT1 3-oxoacid CoA transferase 1 3.1316
RRAGA Ras-related GTP binding A 3.1123
PVALB parvalbumin 3.0698
LUC7L LUC7-like (S. cerevisiae) 3.0532
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 3.0107
TIAM1 T-cell lymphoma invasion and metastasis 1 2.88022
HAND2 heart and neural crest derivatives expressed 2 2.85535
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.85267
NFIL3 nuclear factor, interleukin 3 regulated 2.84265
OSBPL3 oxysterol binding protein-like 3 2.83887
LRRC59 leucine rich repeat containing 59 2.77
BTK Bruton agammaglobulinemia tyrosine kinase 2.72845
SIRT3 sirtuin 3 2.71525
CGRRF1 cell growth regulator with ring finger domain 1 2.6861
CBR3 carbonyl reductase 3 2.66975
SIAH2 siah E3 ubiquitin protein ligase 2 2.65825
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.6569
COL11A1 collagen, type XI, alpha 1 2.63905
TPD52L2 tumor protein D52-like 2 2.6192
WASF3 WAS protein family, member 3 2.6169
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.5919
PRDM5 PR domain containing 5 2.5872
RAB23 RAB23, member RAS oncogene family 2.54885
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 2.50445
FYN FYN proto-oncogene, Src family tyrosine kinase 2.5036
ZNF552 zinc finger protein 552 2.49885
HPSE heparanase 2.49535
CCDC15 coiled-coil domain containing 15 2.4885
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.48415
TCTN2 tectonic family member 2 2.4727
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.4707
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 2.4679
CAVIN2 caveolae associated protein 2 2.4608
MEFV Mediterranean fever 2.4532
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.45215
DEPDC1 DEP domain containing 1 2.44935
TNN tenascin N 2.4384
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.4153
SRP9 signal recognition particle 9kDa 2.4133
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.413
NT5M 5',3'-nucleotidase, mitochondrial 2.4112
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.4029
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.39035
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.36975
SLCO1B3 solute carrier organic anion transporter family, member 1B3 2.35755
PLS3 plastin 3 2.3571
WASHC3 WASH complex subunit 3 2.34955
PTK2 protein tyrosine kinase 2 2.34745
DCLK1 doublecortin-like kinase 1 2.34555
TACC3 transforming, acidic coiled-coil containing protein 3 2.3437
ZNF141 zinc finger protein 141 2.3372
MAB21L2 mab-21-like 2 (C. elegans) 2.33685
HAS2 hyaluronan synthase 2 2.32065
CKB creatine kinase, brain 2.312
PHOX2B paired-like homeobox 2b 2.3099
MSLN mesothelin 2.30865
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.30413
MX1 MX dynamin-like GTPase 1 2.2927
EBF2 early B-cell factor 2 2.2908
FAM184A family with sequence similarity 184, member A 2.28795
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 2.2859
SLC25A46 solute carrier family 25, member 46 2.2852
ZNF281 zinc finger protein 281 2.28435
CD9 CD9 molecule 2.27085
TM4SF1 transmembrane 4 L six family member 1 2.26152
ATP5ME ATP synthase membrane subunit e 2.2499
TRIM66 tripartite motif containing 66 2.23665
OMD osteomodulin 2.2366
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.2353
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.23403
CBX1 chromobox homolog 1 2.22935
EVA1B eva-1 homolog B (C. elegans) 2.21975
FAM3C family with sequence similarity 3, member C 2.21955
IL5 interleukin 5 2.21425
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.2137
RIN1 Ras and Rab interactor 1 2.2102
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.207
A4GALT alpha 1,4-galactosyltransferase 2.2059
INSIG1 insulin induced gene 1 2.2051
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.1885
UGT2B10 UDP glucuronosyltransferase 2 family, polypeptide B10 2.1826
EIF4A3 eukaryotic translation initiation factor 4A3 2.1808
MXRA7 matrix-remodelling associated 7 2.18065
PCGF3 polycomb group ring finger 3 2.17702
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.16983
PCP4 Purkinje cell protein 4 2.16845
POLR1F RNA polymerase I subunit F 2.16625
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.16565
MAG myelin associated glycoprotein 2.16555
CBR4 carbonyl reductase 4 2.16325
KITLG KIT ligand 2.16017
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 2.15915
CCNK cyclin K 2.15145
ZNF528 zinc finger protein 528 2.1467
S100A10 S100 calcium binding protein A10 2.144
DUX4 double homeobox 4 2.13735
COL6A1 collagen, type VI, alpha 1 2.1356
WWC3 WWC family member 3 2.1328
GPATCH8 G patch domain containing 8 2.12608
ITPKA inositol-trisphosphate 3-kinase A 2.12545
DLAT dihydrolipoamide S-acetyltransferase 2.12538
LOX lysyl oxidase 2.12222
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 2.11875
LGI1 leucine-rich, glioma inactivated 1 2.11785
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.1162
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.11475
SMIM40 small integral membrane protein 40 2.11075
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.10945
RBMY1J RNA binding motif protein, Y-linked, family 1, member J 2.09965
FSCN2 fascin actin-bundling protein 2, retinal 2.0991
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.0955
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 2.09154
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.0914
CYTH3 cytohesin 3 2.0891
TACC1 transforming, acidic coiled-coil containing protein 1 2.08875
METTL16 methyltransferase like 16 2.0849
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.0822
DNM3 dynamin 3 2.073
HAND1 heart and neural crest derivatives expressed 1 2.0709
ZBTB5 zinc finger and BTB domain containing 5 2.0695
SNAP91 synaptosomal-associated protein, 91kDa 2.06815
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 2.06547
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 2.0613
OSBPL7 oxysterol binding protein-like 7 2.05905
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.05875
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.05695
GRM3 glutamate receptor, metabotropic 3 2.0547
ZSCAN16 zinc finger and SCAN domain containing 16 2.05435
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 2.05288
PRRC2A proline-rich coiled-coil 2A 2.05188
DEFA5 defensin, alpha 5, Paneth cell-specific 2.0416
TSHR thyroid stimulating hormone receptor 2.0412
KCTD5 potassium channel tetramerization domain containing 5 2.0411
CDK5RAP2 CDK5 regulatory subunit associated protein 2 2.0371
CKS2 CDC28 protein kinase regulatory subunit 2 2.03435
CRIPTO3 cripto, EGF-CFC family member 3 2.031
EMP1 epithelial membrane protein 1 2.02938
ARPC4-TTLL3 ARPC4-TTLL3 readthrough 2.02703
L1TD1 LINE-1 type transposase domain containing 1 2.02025
PF4V1 platelet factor 4 variant 1 2.0064
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.004
ZBTB38 zinc finger and BTB domain containing 38 2.0031
ARMC7 armadillo repeat containing 7 2.0008

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -10.0
USP6NL USP6 N-terminal like -6.0515
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -5.4955
NGRN neugrin, neurite outgrowth associated -5.3852
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -5.33725
LDHD lactate dehydrogenase D -5.2619
FBXL12 F-box and leucine-rich repeat protein 12 -5.0012
FABP5 fatty acid binding protein 5 (psoriasis-associated) -5.0
SYNE2 spectrin repeat containing, nuclear envelope 2 -4.5756
KDM3A lysine (K)-specific demethylase 3A -4.5194
THAP11 THAP domain containing 11 -4.47865
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -4.44285
ZDHHC6 zinc finger, DHHC-type containing 6 -4.38375
HMG20B high mobility group 20B -4.37175
SPAG4 sperm associated antigen 4 -4.31995
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -3.87645
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -3.86383
RFC2 replication factor C (activator 1) 2, 40kDa -3.8461
GALE UDP-galactose-4-epimerase -3.6782
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 -3.6098
CAB39 calcium binding protein 39 -3.3987
RGS2 regulator of G-protein signaling 2 -3.39815
DUSP6 dual specificity phosphatase 6 -3.37073
AKAP8 A kinase (PRKA) anchor protein 8 -3.3226
FBXW4 F-box and WD repeat domain containing 4 -3.30805
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -3.28635
GDF15 growth differentiation factor 15 -3.14025
ARHGAP17 Rho GTPase activating protein 17 -3.1352
PTEN phosphatase and tensin homolog -3.10769
PCNA proliferating cell nuclear antigen -3.0612
PPP4C protein phosphatase 4, catalytic subunit -3.024
FAM174B family with sequence similarity 174, member B -3.00705
TRAP1 TNF receptor-associated protein 1 -2.9966
GTPBP8 GTP-binding protein 8 (putative) -2.98575
ZMIZ1 zinc finger, MIZ-type containing 1 -2.9809
NR2F2 nuclear receptor subfamily 2, group F, member 2 -2.95606
MACF1 microtubule-actin crosslinking factor 1 -2.95595
MAPK13 mitogen-activated protein kinase 13 -2.94182
R3HDM2 R3H domain containing 2 -2.9418
CCNB2 cyclin B2 -2.86275
TCTN1 tectonic family member 1 -2.8585
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.85705
THUMPD1 THUMP domain containing 1 -2.85442
CFDP1 craniofacial development protein 1 -2.82802
TCEAL4 transcription elongation factor A (SII)-like 4 -2.78205
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -2.71443
DCTN5 dynactin 5 (p25) -2.66263
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.6558
ZNF652 zinc finger protein 652 -2.63265
ZNF394 zinc finger protein 394 -2.63025
CSH2 chorionic somatomammotropin hormone 2 -2.6101
IFT52 intraflagellar transport 52 -2.58465
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -2.57111
AFTPH aftiphilin -2.56815
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.53825
SGF29 SAGA complex associated factor 29 -2.5361
ACP5 acid phosphatase 5, tartrate resistant -2.5281
MRPL34 mitochondrial ribosomal protein L34 -2.51415
GH1 growth hormone 1 -2.50779
EIF3G eukaryotic translation initiation factor 3, subunit G -2.49225
UBFD1 ubiquitin family domain containing 1 -2.4686
LCMT1 leucine carboxyl methyltransferase 1 -2.4627
PALB2 partner and localizer of BRCA2 -2.4541
SMIM7 small integral membrane protein 7 -2.45362
C1QA complement component 1, q subcomponent, A chain -2.4455
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -2.4067
SLC10A3 solute carrier family 10, member 3 -2.38855
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -2.38075
CNN1 calponin 1, basic, smooth muscle -2.37565
TRMT61B tRNA methyltransferase 61B -2.34945
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.34635
LARS1 leucyl-tRNA synthetase 1 -2.33455
BBX bobby sox homolog (Drosophila) -2.32893
BCL2A1 BCL2-related protein A1 -2.3246
HAX1 HCLS1 associated protein X-1 -2.3218
PRR14 proline rich 14 -2.31725
TMEM214 transmembrane protein 214 -2.303
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.2998
IRF2BP1 interferon regulatory factor 2 binding protein 1 -2.295
SCYL3 SCY1-like 3 (S. cerevisiae) -2.29052
RMDN3 regulator of microtubule dynamics 3 -2.28325
DEF8 differentially expressed in FDCP 8 homolog (mouse) -2.2814
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.27798
LDAF1 lipid droplet assembly factor 1 -2.27555
BCKDK branched chain ketoacid dehydrogenase kinase -2.27305
CSHL1 chorionic somatomammotropin hormone-like 1 -2.2645
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.25272
ZNF124 zinc finger protein 124 -2.25065
TDRD3 tudor domain containing 3 -2.2459
CNOT2 CCR4-NOT transcription complex, subunit 2 -2.23955
ELF4 E74-like factor 4 (ets domain transcription factor) -2.23588
GLOD4 glyoxalase domain containing 4 -2.2332
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -2.23268
ZNF426 zinc finger protein 426 -2.2262
FAIM Fas apoptotic inhibitory molecule -2.20705
AHDC1 AT hook, DNA binding motif, containing 1 -2.2061
INTS8 integrator complex subunit 8 -2.1954
AGBL5 ATP/GTP binding protein-like 5 -2.19245
MRPL4 mitochondrial ribosomal protein L4 -2.19145
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) -2.18845
CD48 CD48 molecule -2.17895
GYPC glycophorin C (Gerbich blood group) -2.17785
FOS FBJ murine osteosarcoma viral oncogene homolog -2.16715
REXO5 RNA exonuclease 5 -2.16105
RABAC1 Rab acceptor 1 (prenylated) -2.1494
AMPD2 adenosine monophosphate deaminase 2 -2.1473
CHIT1 chitinase 1 (chitotriosidase) -2.1459
APOO apolipoprotein O -2.1374
ITGB1BP1 integrin beta 1 binding protein 1 -2.13497
COMMD9 COMM domain containing 9 -2.1262
REEP5 receptor accessory protein 5 -2.1255
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 -2.1145
MCM3 minichromosome maintenance complex component 3 -2.11365
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.1127
RENBP renin binding protein -2.11235
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.10865
YY1AP1 YY1 associated protein 1 -2.10745
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.1
UQCRC2 ubiquinol-cytochrome c reductase core protein II -2.09885
PHF21A PHD finger protein 21A -2.09625
PRCP prolylcarboxypeptidase (angiotensinase C) -2.09395
CORO1A coronin, actin binding protein, 1A -2.0937
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.0934
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.08927
COPZ1 coatomer protein complex, subunit zeta 1 -2.0872
LIMS2 LIM and senescent cell antigen-like domains 2 -2.0825
CDC16 cell division cycle 16 -2.07678
STX10 syntaxin 10 -2.0759
PCGF1 polycomb group ring finger 1 -2.06815
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -2.06465
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.0623
KCTD13 potassium channel tetramerization domain containing 13 -2.06023
COPG1 coatomer protein complex, subunit gamma 1 -2.0583
MNT MAX network transcriptional repressor -2.058
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 -2.05595
ITFG1 integrin alpha FG-GAP repeat containing 1 -2.0546
LAMC3 laminin, gamma 3 -2.0486
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 -2.04738
SH3GL1 SH3-domain GRB2-like 1 -2.0441
ARMCX1 armadillo repeat containing, X-linked 1 -2.04245
FHIT fragile histidine triad -2.04
KATNIP katanin interacting protein -2.03885
ZNF136 zinc finger protein 136 -2.03405
LITAF lipopolysaccharide-induced TNF factor -2.03282
MED24 mediator complex subunit 24 -2.0328
ZNF706 zinc finger protein 706 -2.02515
HTD2 hydroxyacyl-thioester dehydratase type 2 -2.02425
BLMH bleomycin hydrolase -2.0161
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -2.0139
ZNF14 zinc finger protein 14 -2.01265
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.01043
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.00775
ERI2 ERI1 exoribonuclease family member 2 -2.00355
POGZ pogo transposable element with ZNF domain -2.00157
ELAPOR1 endosome-lysosome associated apoptosis and autophagy regulator 1 -2.00115