CRCGN011_HEPG2_24H:B08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 19.9 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN011_HEPG2_24H:B08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CARMIL1 capping protein regulator and myosin 1 linker 1 5.9313
LCN2 lipocalin 2 5.7123
MYLK myosin light chain kinase 4.9557
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.796
MAP7 microtubule-associated protein 7 4.02465
SSBP2 single-stranded DNA binding protein 2 3.59785
TIAM1 T-cell lymphoma invasion and metastasis 1 3.40922
GPER1 G protein-coupled estrogen receptor 1 3.2915
TOPBP1 topoisomerase (DNA) II binding protein 1 2.779
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.7596
DYNLT3 dynein, light chain, Tctex-type 3 2.71315
SMAD3 SMAD family member 3 2.6494
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.44785
LAMA5 laminin, alpha 5 2.39535
EXOC2 exocyst complex component 2 2.2383
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.23553
TXNRD1 thioredoxin reductase 1 2.21365
OSBPL11 oxysterol binding protein-like 11 2.2004
DIPK1A divergent protein kinase domain 1A 2.19045
KLHL21 kelch-like family member 21 2.1782
SCYL2 SCY1-like 2 (S. cerevisiae) 2.1203
SPOUT1 SPOUT domain containing methyltransferase 1 2.1052
GARRE1 granule associated Rac and RHOG effector 1 2.0207

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -8.0128
TM9SF3 transmembrane 9 superfamily member 3 -5.37445
ADI1 acireductone dioxygenase 1 -4.47995
OXA1L oxidase (cytochrome c) assembly 1-like -4.123
RPS5 ribosomal protein S5 -3.87185
TCTN1 tectonic family member 1 -3.23565
MAPK13 mitogen-activated protein kinase 13 -3.19515
CHIC2 cysteine-rich hydrophobic domain 2 -3.08405
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog -2.87965
KRT9 keratin 9, type I -2.6017
EVC Ellis van Creveld protein -2.5894
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -2.44475
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.4423
GFRA3 GDNF family receptor alpha 3 -2.41725
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 -2.40275
MAP3K10 mitogen-activated protein kinase kinase kinase 10 -2.38265
FAM90A1 family with sequence similarity 90, member A1 -2.37705
DGKH diacylglycerol kinase, eta -2.33935
STXBP1 syntaxin binding protein 1 -2.32445
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) -2.3177
GLI1 GLI family zinc finger 1 -2.29355
IL36R interleukin 36 receptor -2.27205
PITX3 paired-like homeodomain 3 -2.2503
TBX2 T-box 2 -2.23017
RFC2 replication factor C (activator 1) 2, 40kDa -2.21478
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 -2.20425
RPL3L ribosomal protein L3-like -2.17415
HEATR1 HEAT repeat containing 1 -2.1739
GLT8D2 glycosyltransferase 8 domain containing 2 -2.1713
TMED7 transmembrane emp24 protein transport domain containing 7 -2.16855
P3H1 prolyl 3-hydroxylase 1 -2.16325
ANGPT4 angiopoietin 4 -2.15865
GPR50 G protein-coupled receptor 50 -2.1372
PDIA2 protein disulfide isomerase family A, member 2 -2.1281
MYBPC3 myosin binding protein C, cardiac -2.12435
MMP17 matrix metallopeptidase 17 (membrane-inserted) -2.11405
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -2.1099
GMEB1 glucocorticoid modulatory element binding protein 1 -2.08245
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B -2.0821
ALPL alkaline phosphatase, liver/bone/kidney -2.07465
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -2.0624
NME3 NME/NM23 nucleoside diphosphate kinase 3 -2.0566
GALR3 galanin receptor 3 -2.04745
AIRE autoimmune regulator -2.046
SYT2 synaptotagmin II -2.0318
EXT1 exostosin glycosyltransferase 1 -2.03047
ZNF76 zinc finger protein 76 -2.02245