CRCGN011_HEPG2_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 9.95 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN011_HEPG2_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.14275
DYNLT3 dynein, light chain, Tctex-type 3 4.71165
PNKP polynucleotide kinase 3'-phosphatase 4.41325
TLR4 toll-like receptor 4 4.34065
CCDC85B coiled-coil domain containing 85B 4.2444
NMU neuromedin U 3.61155
EVL Enah/Vasp-like 3.60175
ZNF589 zinc finger protein 589 3.43818
PLSCR3 phospholipid scramblase 3 3.30408
CEP57 centrosomal protein 57kDa 3.21489
MEST mesoderm specific transcript 3.1767
COQ8A coenzyme Q8A 3.11625
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 2.79142
GPER1 G protein-coupled estrogen receptor 1 2.76172
WASF3 WAS protein family, member 3 2.53755
FASTKD5 FAST kinase domains 5 2.5044
JADE2 jade family PHD finger 2 2.42077
ZBTB11 zinc finger and BTB domain containing 11 2.3512
SLC35B1 solute carrier family 35, member B1 2.32615
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.2383
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.1941
DIPK1A divergent protein kinase domain 1A 2.17298
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle 2.17205
CD40 CD40 molecule, TNF receptor superfamily member 5 2.14649
GFOD1 glucose-fructose oxidoreductase domain containing 1 2.1459
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 2.1253
TREM1 triggering receptor expressed on myeloid cells 1 2.0958
FIBP fibroblast growth factor (acidic) intracellular binding protein 2.0771

decreased expression

Symbol Name Standardized Value
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 -5.3859
GDF15 growth differentiation factor 15 -5.0
LDHD lactate dehydrogenase D -5.0
NUP85 nucleoporin 85kDa -4.72495
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.7102
TLCD3A TLC domain containing 3A -4.59835
ZMIZ1 zinc finger, MIZ-type containing 1 -4.53455
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.36975
ANKRD10 ankyrin repeat domain 10 -4.28595
MAPK13 mitogen-activated protein kinase 13 -3.7582
OXA1L oxidase (cytochrome c) assembly 1-like -3.088
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.72578
EVPL envoplakin -2.5917
BPHL biphenyl hydrolase-like (serine hydrolase) -2.4385
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.4222
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -2.32315
SAP30BP SAP30 binding protein -2.2645
NRIP1 nuclear receptor interacting protein 1 -2.26447
MAP3K6 mitogen-activated protein kinase kinase kinase 6 -2.23705
GPS1 G protein pathway suppressor 1 -2.23435
TCEAL4 transcription elongation factor A (SII)-like 4 -2.12985
MRPL58 mitochondrial ribosomal protein L58 -2.11565
PPOX protoporphyrinogen oxidase -2.10795
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 -2.10695
NPTXR neuronal pentraxin receptor -2.07805
MRPS7 mitochondrial ribosomal protein S7 -2.06735
CHAF1B chromatin assembly factor 1, subunit B (p60) -2.05795
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 -2.04505
NT5C 5', 3'-nucleotidase, cytosolic -2.0371
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 -2.01665
PRPF3 pre-mRNA processing factor 3 -2.01165
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.0112