CRCGN011_HEPG2_24H:B10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2,4-dichlorophenol 4.98 um perturbation at 24 h in HEPG2 (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN011_HEPG2_24H:B10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SQOR sulfide quinone oxidoreductase 5.4338
KLHL21 kelch-like family member 21 5.42325
MOK MOK protein kinase 5.1427
INTS3 integrator complex subunit 3 4.90935
MYLK myosin light chain kinase 4.76985
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.7338
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 4.49545
PHKA1 phosphorylase kinase, alpha 1 (muscle) 4.14275
STK10 serine/threonine kinase 10 3.83317
GFOD1 glucose-fructose oxidoreductase domain containing 1 3.7023
MICALL1 MICAL-like 1 3.66558
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.4182
RXYLT1 ribitol xylosyltransferase 1 3.3913
CYCS cytochrome c, somatic 3.3592
VGLL4 vestigial-like family member 4 3.2368
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.16235
COL11A1 collagen, type XI, alpha 1 3.01985
SSBP2 single-stranded DNA binding protein 2 2.85602
NUP133 nucleoporin 133kDa 2.76975
SATB1 SATB homeobox 1 2.7015
CCNF cyclin F 2.5928
BIRC2 baculoviral IAP repeat containing 2 2.5537
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.5064
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.35738
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.32925
GPATCH8 G patch domain containing 8 2.30832
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 2.30142
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.23905
NUCB2 nucleobindin 2 2.17955
HOOK3 hook microtubule-tethering protein 3 2.15525
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.13665
DIPK1A divergent protein kinase domain 1A 2.10173
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 2.09765
GATA2 GATA binding protein 2 2.04402
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.043
RNPS1 RNA binding protein S1, serine-rich domain 2.0263
PHF21A PHD finger protein 21A 2.00125

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.37755
VAT1 vesicle amine transport 1 -5.37535
CDC20 cell division cycle 20 -5.31545
CASP7 caspase 7, apoptosis-related cysteine peptidase -5.24355
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -5.08803
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.9299
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -4.8625
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.7725
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -4.42107
MTFR1 mitochondrial fission regulator 1 -4.17075
GDF15 growth differentiation factor 15 -3.7537
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.74515
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -3.64095
GNAS GNAS complex locus -3.61506
DCK deoxycytidine kinase -2.9324
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 -2.6321
CD1B CD1b molecule -2.4438
SLC2A4RG SLC2A4 regulator -2.27735
CHIC2 cysteine-rich hydrophobic domain 2 -2.23925
RNF167 ring finger protein 167 -2.18055
LINC02762 long intergenic non-protein coding RNA 2762 -2.14135
TCFL5 transcription factor-like 5 (basic helix-loop-helix) -2.13765
TES testin LIM domain protein -2.127
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -2.0615
THAP4 THAP domain containing 4 -2.01645