| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | 2,4-dichlorophenol 1.24 um perturbation at 24 h in HEPG2 (Carcinogenome) |
| Similar Terms | |
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132 genes differentially expressed following the CRCGN011_HEPG2_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 8.84335 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 7.9952 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 7.3529 |
| PAF1 | Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) | 6.2727 |
| MYLK | myosin light chain kinase | 5.7909 |
| CSK | c-src tyrosine kinase | 5.48555 |
| CIAO3 | cytosolic iron-sulfur assembly component 3 | 5.04635 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 5.0097 |
| PPARG | peroxisome proliferator-activated receptor gamma | 4.80155 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 4.75215 |
| BIRC2 | baculoviral IAP repeat containing 2 | 4.57875 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 4.51248 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | 3.99275 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 3.78678 |
| MAP7 | microtubule-associated protein 7 | 3.36875 |
| BMP4 | bone morphogenetic protein 4 | 3.12825 |
| CCL2 | chemokine (C-C motif) ligand 2 | 3.12165 |
| ATP11B | ATPase, class VI, type 11B | 3.1101 |
| ARSL | arylsulfatase L | 2.75985 |
| JADE2 | jade family PHD finger 2 | 2.69537 |
| CHEK2 | checkpoint kinase 2 | 2.67898 |
| WASF2 | WAS protein family, member 2 | 2.6778 |
| TERF2 | telomeric repeat binding factor 2 | 2.6701 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 2.6181 |
| BCAS2 | breast carcinoma amplified sequence 2 | 2.6007 |
| INTS6 | integrator complex subunit 6 | 2.58133 |
| SYNGR1 | synaptogyrin 1 | 2.53067 |
| GAR1 | GAR1 ribonucleoprotein | 2.5284 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 2.504 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 2.39155 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 2.39015 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.36085 |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 | 2.33505 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 2.3347 |
| CRTAM | cytotoxic and regulatory T cell molecule | 2.3176 |
| NENF | neudesin neurotrophic factor | 2.30125 |
| CCNF | cyclin F | 2.27003 |
| VRK1 | vaccinia related kinase 1 | 2.2565 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 2.2516 |
| KCND1 | potassium channel, voltage gated Shal related subfamily D, member 1 | 2.2388 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 2.23635 |
| PTGDR | prostaglandin D2 receptor (DP) | 2.22445 |
| JMJD1C | jumonji domain containing 1C | 2.22045 |
| IFNG | interferon, gamma | 2.2127 |
| ANKRA2 | ankyrin repeat, family A (RFXANK-like), 2 | 2.21005 |
| LIPC | lipase, hepatic | 2.19445 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 2.19045 |
| ITPKC | inositol-trisphosphate 3-kinase C | 2.18115 |
| PPIH | peptidylprolyl isomerase H (cyclophilin H) | 2.17385 |
| PRR15L | proline rich 15-like | 2.16945 |
| ATAD2B | ATPase family, AAA domain containing 2B | 2.1652 |
| SLC75A1 | solute carrier family 75 member 1 | 2.16115 |
| CACNG2 | calcium channel, voltage-dependent, gamma subunit 2 | 2.14295 |
| PEF1 | penta-EF-hand domain containing 1 | 2.11085 |
| CDC42 | cell division cycle 42 | 2.10967 |
| TAC1 | tachykinin, precursor 1 | 2.0941 |
| SPECC1L | sperm antigen with calponin homology and coiled-coil domains 1-like | 2.0899 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 | 2.08451 |
| RBM10 | RNA binding motif protein 10 | 2.08097 |
| EIF2D | eukaryotic translation initiation factor 2D | 2.07745 |
| MED4 | mediator complex subunit 4 | 2.0744 |
| SKI | SKI proto-oncogene | 2.0719 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | 2.06725 |
| ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 2.05245 |
| HOPX | HOP homeobox | 2.04815 |
| AGO1 | argonaute RISC catalytic component 1 | 2.0131 |
| SRGN | serglycin | 2.00567 |
| GPHN | gephyrin | 2.00125 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KDM3A | lysine (K)-specific demethylase 3A | -10.0 |
| ADI1 | acireductone dioxygenase 1 | -10.0 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -8.42175 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -5.4867 |
| CCDC86 | coiled-coil domain containing 86 | -5.2603 |
| LAP3 | leucine aminopeptidase 3 | -5.124 |
| FAIM | Fas apoptotic inhibitory molecule | -5.02945 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -5.0 |
| DNM1L | dynamin 1-like | -4.9364 |
| RPN1 | ribophorin I | -4.9097 |
| TSEN2 | TSEN2 tRNA splicing endonuclease subunit | -4.86815 |
| CASP7 | caspase 7, apoptosis-related cysteine peptidase | -4.83555 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | -4.77775 |
| GOLT1B | golgi transport 1B | -4.5932 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | -4.1368 |
| HMG20B | high mobility group 20B | -4.08665 |
| GRWD1 | glutamate-rich WD repeat containing 1 | -3.81465 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -3.6495 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | -3.5743 |
| GNAS | GNAS complex locus | -3.34939 |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | -3.2736 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | -3.27055 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -3.23897 |
| TLCD3A | TLC domain containing 3A | -2.98335 |
| PDZD2 | PDZ domain containing 2 | -2.9213 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.9042 |
| TBCB | tubulin folding cofactor B | -2.88328 |
| CCNB2 | cyclin B2 | -2.80665 |
| ACLY | ATP citrate lyase | -2.79243 |
| B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | -2.76985 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -2.7616 |
| INTS13 | integrator complex subunit 13 | -2.7614 |
| CAPNS1 | calpain, small subunit 1 | -2.7356 |
| TOMM22 | translocase of outer mitochondrial membrane 22 homolog (yeast) | -2.7004 |
| COPG1 | coatomer protein complex, subunit gamma 1 | -2.686 |
| DBN1 | drebrin 1 | -2.58455 |
| ZNF322 | zinc finger protein 322 | -2.4998 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | -2.49465 |
| TUBB2B | tubulin, beta 2B class IIb | -2.44265 |
| TRIB2 | tribbles pseudokinase 2 | -2.40998 |
| UFD1 | ubiquitin recognition factor in ER associated degradation 1 | -2.39205 |
| TRAP1 | TNF receptor-associated protein 1 | -2.38865 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -2.3704 |
| MEX3D | mex-3 RNA binding family member D | -2.3182 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -2.2768 |
| DOLK | dolichol kinase | -2.2648 |
| DBR1 | debranching RNA lariats 1 | -2.2606 |
| BPHL | biphenyl hydrolase-like (serine hydrolase) | -2.24975 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -2.2453 |
| CHEK1 | checkpoint kinase 1 | -2.2374 |
| MRPL35 | mitochondrial ribosomal protein L35 | -2.22725 |
| MYD88 | myeloid differentiation primary response 88 | -2.226 |
| SLC35F2 | solute carrier family 35, member F2 | -2.17855 |
| IPO13 | importin 13 | -2.15995 |
| ISG15 | ISG15 ubiquitin-like modifier | -2.1592 |
| ATG4A | autophagy related 4A, cysteine peptidase | -2.1297 |
| MARCHF2 | membrane associated ring-CH-type finger 2 | -2.1 |
| GPX4 | glutathione peroxidase 4 | -2.08795 |
| MOCS3 | molybdenum cofactor synthesis 3 | -2.0799 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -2.07585 |
| SLFN12 | schlafen family member 12 | -2.0679 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -2.06515 |
| COG2 | component of oligomeric golgi complex 2 | -2.022 |
| COTL1 | coactosin-like F-actin binding protein 1 | -2.01405 |
